4J02
Crystal structure of hcv ns5b polymerase in complex with [(1R)-5,8-DICHLORO-1-PROPYL-1,3,4,9-TETRAHYDROPYRANO[3,4-B]INDOL-1-YL]ACETIC ACID
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003723 | molecular_function | RNA binding |
A | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
A | 0039694 | biological_process | viral RNA genome replication |
B | 0003723 | molecular_function | RNA binding |
B | 0003968 | molecular_function | RNA-dependent RNA polymerase activity |
B | 0039694 | biological_process | viral RNA genome replication |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 1JE A 601 |
Chain | Residue |
A | LEU419 |
A | HOH743 |
A | HOH805 |
A | HOH966 |
A | HOH1042 |
A | ARG422 |
A | MET423 |
A | HIS475 |
A | SER476 |
A | TYR477 |
A | LEU497 |
A | ARG501 |
A | TRP528 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE SO4 A 602 |
Chain | Residue |
A | ARG48 |
A | ARG158 |
A | CYS223 |
A | HOH759 |
A | HOH807 |
A | HOH923 |
A | HOH933 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE NA A 603 |
Chain | Residue |
A | ASP220 |
A | THR221 |
A | HOH789 |
A | HOH807 |
A | HOH923 |
A | HOH933 |
site_id | AC4 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE 1JE B 601 |
Chain | Residue |
B | ARG422 |
B | MET423 |
B | HIS475 |
B | SER476 |
B | TYR477 |
B | ARG501 |
B | TRP528 |
B | HOH1060 |
B | HOH1300 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE SO4 B 602 |
Chain | Residue |
B | ARG158 |
B | HOH1085 |
B | HOH1157 |
B | HOH1172 |
B | HOH1206 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE NA B 603 |
Chain | Residue |
B | ASP220 |
B | THR221 |
B | HOH1172 |
B | HOH1206 |
B | HOH1248 |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | ASP220 | |
A | ASP318 | |
A | ASP319 | |
B | ASP220 | |
B | ASP318 | |
B | ASP319 | |
Chain | Residue | Details |
A | SER29 | |
A | SER42 | |
B | SER29 | |
B | SER42 | |