4IZ5

Structure of the complex between ERK2 phosphomimetic mutant and PEA-15

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000165	biological_process	MAPK cascade
A	0000166	molecular_function	nucleotide binding
A	0001784	molecular_function	phosphotyrosine residue binding
A	0003677	molecular_function	DNA binding
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0004707	molecular_function	MAP kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005769	cellular_component	early endosome
A	0005770	cellular_component	late endosome
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005794	cellular_component	Golgi apparatus
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0005901	cellular_component	caveola
A	0005925	cellular_component	focal adhesion
A	0005929	cellular_component	cilium
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006468	biological_process	protein phosphorylation
A	0006915	biological_process	apoptotic process
A	0006935	biological_process	chemotaxis
A	0006974	biological_process	DNA damage response
A	0007165	biological_process	signal transduction
A	0007166	biological_process	cell surface receptor signaling pathway
A	0007173	biological_process	epidermal growth factor receptor signaling pathway
A	0007268	biological_process	chemical synaptic transmission
A	0007507	biological_process	heart development
A	0007611	biological_process	learning or memory
A	0008286	biological_process	insulin receptor signaling pathway
A	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
A	0009887	biological_process	animal organ morphogenesis
A	0010759	biological_process	positive regulation of macrophage chemotaxis
A	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
A	0014032	biological_process	neural crest cell development
A	0014044	biological_process	Schwann cell development
A	0015630	cellular_component	microtubule cytoskeleton
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019858	biological_process	cytosine metabolic process
A	0019902	molecular_function	phosphatase binding
A	0030278	biological_process	regulation of ossification
A	0030641	biological_process	regulation of cellular pH
A	0030878	biological_process	thyroid gland development
A	0031143	cellular_component	pseudopodium
A	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
A	0032206	biological_process	positive regulation of telomere maintenance
A	0032496	biological_process	response to lipopolysaccharide
A	0032872	biological_process	regulation of stress-activated MAPK cascade
A	0033598	biological_process	mammary gland epithelial cell proliferation
A	0034198	biological_process	cellular response to amino acid starvation
A	0035094	biological_process	response to nicotine
A	0035556	biological_process	intracellular signal transduction
A	0035578	cellular_component	azurophil granule lumen
A	0036064	cellular_component	ciliary basal body
A	0038127	biological_process	ERBB signaling pathway
A	0038133	biological_process	ERBB2-ERBB3 signaling pathway
A	0042473	biological_process	outer ear morphogenesis
A	0042552	biological_process	myelination
A	0042802	molecular_function	identical protein binding
A	0043330	biological_process	response to exogenous dsRNA
A	0045202	cellular_component	synapse
A	0045542	biological_process	positive regulation of cholesterol biosynthetic process
A	0045596	biological_process	negative regulation of cell differentiation
A	0048009	biological_process	insulin-like growth factor receptor signaling pathway
A	0048538	biological_process	thymus development
A	0050852	biological_process	T cell receptor signaling pathway
A	0050853	biological_process	B cell receptor signaling pathway
A	0051403	biological_process	stress-activated MAPK cascade
A	0051493	biological_process	regulation of cytoskeleton organization
A	0060020	biological_process	Bergmann glial cell differentiation
A	0060291	biological_process	long-term synaptic potentiation
A	0060324	biological_process	face development
A	0060425	biological_process	lung morphogenesis
A	0060440	biological_process	trachea formation
A	0060716	biological_process	labyrinthine layer blood vessel development
A	0061308	biological_process	cardiac neural crest cell development involved in heart development
A	0061514	biological_process	interleukin-34-mediated signaling pathway
A	0070098	biological_process	chemokine-mediated signaling pathway
A	0070371	biological_process	ERK1 and ERK2 cascade
A	0070849	biological_process	response to epidermal growth factor
A	0071356	biological_process	cellular response to tumor necrosis factor
A	0072584	biological_process	caveolin-mediated endocytosis
A	0072686	cellular_component	mitotic spindle
A	0090170	biological_process	regulation of Golgi inheritance
A	0097542	cellular_component	ciliary tip
A	0106310	molecular_function	protein serine kinase activity
A	0120041	biological_process	positive regulation of macrophage proliferation
A	0150078	biological_process	positive regulation of neuroinflammatory response
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2000641	biological_process	regulation of early endosome to late endosome transport
B	0000165	biological_process	MAPK cascade
B	0000166	molecular_function	nucleotide binding
B	0001784	molecular_function	phosphotyrosine residue binding
B	0003677	molecular_function	DNA binding
B	0004672	molecular_function	protein kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
B	0004707	molecular_function	MAP kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005769	cellular_component	early endosome
B	0005770	cellular_component	late endosome
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005856	cellular_component	cytoskeleton
B	0005886	cellular_component	plasma membrane
B	0005901	cellular_component	caveola
B	0005925	cellular_component	focal adhesion
B	0005929	cellular_component	cilium
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006468	biological_process	protein phosphorylation
B	0006915	biological_process	apoptotic process
B	0006935	biological_process	chemotaxis
B	0006974	biological_process	DNA damage response
B	0007165	biological_process	signal transduction
B	0007166	biological_process	cell surface receptor signaling pathway
B	0007173	biological_process	epidermal growth factor receptor signaling pathway
B	0007268	biological_process	chemical synaptic transmission
B	0007507	biological_process	heart development
B	0007611	biological_process	learning or memory
B	0008286	biological_process	insulin receptor signaling pathway
B	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
B	0009887	biological_process	animal organ morphogenesis
B	0010759	biological_process	positive regulation of macrophage chemotaxis
B	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
B	0014032	biological_process	neural crest cell development
B	0014044	biological_process	Schwann cell development
B	0015630	cellular_component	microtubule cytoskeleton
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019858	biological_process	cytosine metabolic process
B	0019902	molecular_function	phosphatase binding
B	0030278	biological_process	regulation of ossification
B	0030641	biological_process	regulation of cellular pH
B	0030878	biological_process	thyroid gland development
B	0031143	cellular_component	pseudopodium
B	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
B	0032206	biological_process	positive regulation of telomere maintenance
B	0032496	biological_process	response to lipopolysaccharide
B	0032872	biological_process	regulation of stress-activated MAPK cascade
B	0033598	biological_process	mammary gland epithelial cell proliferation
B	0034198	biological_process	cellular response to amino acid starvation
B	0035094	biological_process	response to nicotine
B	0035556	biological_process	intracellular signal transduction
B	0035578	cellular_component	azurophil granule lumen
B	0036064	cellular_component	ciliary basal body
B	0038127	biological_process	ERBB signaling pathway
B	0038133	biological_process	ERBB2-ERBB3 signaling pathway
B	0042473	biological_process	outer ear morphogenesis
B	0042552	biological_process	myelination
B	0042802	molecular_function	identical protein binding
B	0043330	biological_process	response to exogenous dsRNA
B	0045202	cellular_component	synapse
B	0045542	biological_process	positive regulation of cholesterol biosynthetic process
B	0045596	biological_process	negative regulation of cell differentiation
B	0048009	biological_process	insulin-like growth factor receptor signaling pathway
B	0048538	biological_process	thymus development
B	0050852	biological_process	T cell receptor signaling pathway
B	0050853	biological_process	B cell receptor signaling pathway
B	0051403	biological_process	stress-activated MAPK cascade
B	0051493	biological_process	regulation of cytoskeleton organization
B	0060020	biological_process	Bergmann glial cell differentiation
B	0060291	biological_process	long-term synaptic potentiation
B	0060324	biological_process	face development
B	0060425	biological_process	lung morphogenesis
B	0060440	biological_process	trachea formation
B	0060716	biological_process	labyrinthine layer blood vessel development
B	0061308	biological_process	cardiac neural crest cell development involved in heart development
B	0061514	biological_process	interleukin-34-mediated signaling pathway
B	0070098	biological_process	chemokine-mediated signaling pathway
B	0070371	biological_process	ERK1 and ERK2 cascade
B	0070849	biological_process	response to epidermal growth factor
B	0071356	biological_process	cellular response to tumor necrosis factor
B	0072584	biological_process	caveolin-mediated endocytosis
B	0072686	cellular_component	mitotic spindle
B	0090170	biological_process	regulation of Golgi inheritance
B	0097542	cellular_component	ciliary tip
B	0106310	molecular_function	protein serine kinase activity
B	0120041	biological_process	positive regulation of macrophage proliferation
B	0150078	biological_process	positive regulation of neuroinflammatory response
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2000641	biological_process	regulation of early endosome to late endosome transport
C	0000165	biological_process	MAPK cascade
C	0000166	molecular_function	nucleotide binding
C	0001784	molecular_function	phosphotyrosine residue binding
C	0003677	molecular_function	DNA binding
C	0004672	molecular_function	protein kinase activity
C	0004674	molecular_function	protein serine/threonine kinase activity
C	0004707	molecular_function	MAP kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005769	cellular_component	early endosome
C	0005770	cellular_component	late endosome
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005794	cellular_component	Golgi apparatus
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005856	cellular_component	cytoskeleton
C	0005886	cellular_component	plasma membrane
C	0005901	cellular_component	caveola
C	0005925	cellular_component	focal adhesion
C	0005929	cellular_component	cilium
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006468	biological_process	protein phosphorylation
C	0006915	biological_process	apoptotic process
C	0006935	biological_process	chemotaxis
C	0006974	biological_process	DNA damage response
C	0007165	biological_process	signal transduction
C	0007166	biological_process	cell surface receptor signaling pathway
C	0007173	biological_process	epidermal growth factor receptor signaling pathway
C	0007268	biological_process	chemical synaptic transmission
C	0007507	biological_process	heart development
C	0007611	biological_process	learning or memory
C	0008286	biological_process	insulin receptor signaling pathway
C	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
C	0009887	biological_process	animal organ morphogenesis
C	0010759	biological_process	positive regulation of macrophage chemotaxis
C	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
C	0014032	biological_process	neural crest cell development
C	0014044	biological_process	Schwann cell development
C	0015630	cellular_component	microtubule cytoskeleton
C	0016301	molecular_function	kinase activity
C	0016740	molecular_function	transferase activity
C	0019858	biological_process	cytosine metabolic process
C	0019902	molecular_function	phosphatase binding
C	0030278	biological_process	regulation of ossification
C	0030641	biological_process	regulation of cellular pH
C	0030878	biological_process	thyroid gland development
C	0031143	cellular_component	pseudopodium
C	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
C	0032206	biological_process	positive regulation of telomere maintenance
C	0032496	biological_process	response to lipopolysaccharide
C	0032872	biological_process	regulation of stress-activated MAPK cascade
C	0033598	biological_process	mammary gland epithelial cell proliferation
C	0034198	biological_process	cellular response to amino acid starvation
C	0035094	biological_process	response to nicotine
C	0035556	biological_process	intracellular signal transduction
C	0035578	cellular_component	azurophil granule lumen
C	0036064	cellular_component	ciliary basal body
C	0038127	biological_process	ERBB signaling pathway
C	0038133	biological_process	ERBB2-ERBB3 signaling pathway
C	0042473	biological_process	outer ear morphogenesis
C	0042552	biological_process	myelination
C	0042802	molecular_function	identical protein binding
C	0043330	biological_process	response to exogenous dsRNA
C	0045202	cellular_component	synapse
C	0045542	biological_process	positive regulation of cholesterol biosynthetic process
C	0045596	biological_process	negative regulation of cell differentiation
C	0048009	biological_process	insulin-like growth factor receptor signaling pathway
C	0048538	biological_process	thymus development
C	0050852	biological_process	T cell receptor signaling pathway
C	0050853	biological_process	B cell receptor signaling pathway
C	0051403	biological_process	stress-activated MAPK cascade
C	0051493	biological_process	regulation of cytoskeleton organization
C	0060020	biological_process	Bergmann glial cell differentiation
C	0060291	biological_process	long-term synaptic potentiation
C	0060324	biological_process	face development
C	0060425	biological_process	lung morphogenesis
C	0060440	biological_process	trachea formation
C	0060716	biological_process	labyrinthine layer blood vessel development
C	0061308	biological_process	cardiac neural crest cell development involved in heart development
C	0061514	biological_process	interleukin-34-mediated signaling pathway
C	0070098	biological_process	chemokine-mediated signaling pathway
C	0070371	biological_process	ERK1 and ERK2 cascade
C	0070849	biological_process	response to epidermal growth factor
C	0071356	biological_process	cellular response to tumor necrosis factor
C	0072584	biological_process	caveolin-mediated endocytosis
C	0072686	cellular_component	mitotic spindle
C	0090170	biological_process	regulation of Golgi inheritance
C	0097542	cellular_component	ciliary tip
C	0106310	molecular_function	protein serine kinase activity
C	0120041	biological_process	positive regulation of macrophage proliferation
C	0150078	biological_process	positive regulation of neuroinflammatory response
C	1904813	cellular_component	ficolin-1-rich granule lumen
C	2000641	biological_process	regulation of early endosome to late endosome transport
D	0000165	biological_process	MAPK cascade
D	0000166	molecular_function	nucleotide binding
D	0001784	molecular_function	phosphotyrosine residue binding
D	0003677	molecular_function	DNA binding
D	0004672	molecular_function	protein kinase activity
D	0004674	molecular_function	protein serine/threonine kinase activity
D	0004707	molecular_function	MAP kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005769	cellular_component	early endosome
D	0005770	cellular_component	late endosome
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005794	cellular_component	Golgi apparatus
D	0005813	cellular_component	centrosome
D	0005819	cellular_component	spindle
D	0005829	cellular_component	cytosol
D	0005856	cellular_component	cytoskeleton
D	0005886	cellular_component	plasma membrane
D	0005901	cellular_component	caveola
D	0005925	cellular_component	focal adhesion
D	0005929	cellular_component	cilium
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006468	biological_process	protein phosphorylation
D	0006915	biological_process	apoptotic process
D	0006935	biological_process	chemotaxis
D	0006974	biological_process	DNA damage response
D	0007165	biological_process	signal transduction
D	0007166	biological_process	cell surface receptor signaling pathway
D	0007173	biological_process	epidermal growth factor receptor signaling pathway
D	0007268	biological_process	chemical synaptic transmission
D	0007507	biological_process	heart development
D	0007611	biological_process	learning or memory
D	0008286	biological_process	insulin receptor signaling pathway
D	0008353	molecular_function	RNA polymerase II CTD heptapeptide repeat kinase activity
D	0009887	biological_process	animal organ morphogenesis
D	0010759	biological_process	positive regulation of macrophage chemotaxis
D	0010800	biological_process	positive regulation of peptidyl-threonine phosphorylation
D	0014032	biological_process	neural crest cell development
D	0014044	biological_process	Schwann cell development
D	0015630	cellular_component	microtubule cytoskeleton
D	0016301	molecular_function	kinase activity
D	0016740	molecular_function	transferase activity
D	0019858	biological_process	cytosine metabolic process
D	0019902	molecular_function	phosphatase binding
D	0030278	biological_process	regulation of ossification
D	0030641	biological_process	regulation of cellular pH
D	0030878	biological_process	thyroid gland development
D	0031143	cellular_component	pseudopodium
D	0031663	biological_process	lipopolysaccharide-mediated signaling pathway
D	0032206	biological_process	positive regulation of telomere maintenance
D	0032496	biological_process	response to lipopolysaccharide
D	0032872	biological_process	regulation of stress-activated MAPK cascade
D	0033598	biological_process	mammary gland epithelial cell proliferation
D	0034198	biological_process	cellular response to amino acid starvation
D	0035094	biological_process	response to nicotine
D	0035556	biological_process	intracellular signal transduction
D	0035578	cellular_component	azurophil granule lumen
D	0036064	cellular_component	ciliary basal body
D	0038127	biological_process	ERBB signaling pathway
D	0038133	biological_process	ERBB2-ERBB3 signaling pathway
D	0042473	biological_process	outer ear morphogenesis
D	0042552	biological_process	myelination
D	0042802	molecular_function	identical protein binding
D	0043330	biological_process	response to exogenous dsRNA
D	0045202	cellular_component	synapse
D	0045542	biological_process	positive regulation of cholesterol biosynthetic process
D	0045596	biological_process	negative regulation of cell differentiation
D	0048009	biological_process	insulin-like growth factor receptor signaling pathway
D	0048538	biological_process	thymus development
D	0050852	biological_process	T cell receptor signaling pathway
D	0050853	biological_process	B cell receptor signaling pathway
D	0051403	biological_process	stress-activated MAPK cascade
D	0051493	biological_process	regulation of cytoskeleton organization
D	0060020	biological_process	Bergmann glial cell differentiation
D	0060291	biological_process	long-term synaptic potentiation
D	0060324	biological_process	face development
D	0060425	biological_process	lung morphogenesis
D	0060440	biological_process	trachea formation
D	0060716	biological_process	labyrinthine layer blood vessel development
D	0061308	biological_process	cardiac neural crest cell development involved in heart development
D	0061514	biological_process	interleukin-34-mediated signaling pathway
D	0070098	biological_process	chemokine-mediated signaling pathway
D	0070371	biological_process	ERK1 and ERK2 cascade
D	0070849	biological_process	response to epidermal growth factor
D	0071356	biological_process	cellular response to tumor necrosis factor
D	0072584	biological_process	caveolin-mediated endocytosis
D	0072686	cellular_component	mitotic spindle
D	0090170	biological_process	regulation of Golgi inheritance
D	0097542	cellular_component	ciliary tip
D	0106310	molecular_function	protein serine kinase activity
D	0120041	biological_process	positive regulation of macrophage proliferation
D	0150078	biological_process	positive regulation of neuroinflammatory response
D	1904813	cellular_component	ficolin-1-rich granule lumen
D	2000641	biological_process	regulation of early endosome to late endosome transport
E	0000165	biological_process	MAPK cascade
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005875	cellular_component	microtubule associated complex
E	0006915	biological_process	apoptotic process
E	0042981	biological_process	regulation of apoptotic process
E	0046325	biological_process	negative regulation of D-glucose import
E	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
E	1902043	biological_process	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
F	0000165	biological_process	MAPK cascade
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005875	cellular_component	microtubule associated complex
F	0006915	biological_process	apoptotic process
F	0042981	biological_process	regulation of apoptotic process
F	0046325	biological_process	negative regulation of D-glucose import
F	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
F	1902043	biological_process	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
G	0000165	biological_process	MAPK cascade
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005875	cellular_component	microtubule associated complex
G	0006915	biological_process	apoptotic process
G	0042981	biological_process	regulation of apoptotic process
G	0046325	biological_process	negative regulation of D-glucose import
G	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
G	1902043	biological_process	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
H	0000165	biological_process	MAPK cascade
H	0005515	molecular_function	protein binding
H	0005654	cellular_component	nucleoplasm
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005875	cellular_component	microtubule associated complex
H	0006915	biological_process	apoptotic process
H	0042981	biological_process	regulation of apoptotic process
H	0046325	biological_process	negative regulation of D-glucose import
H	1902042	biological_process	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
H	1902043	biological_process	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP A 900

Chain	Residue
A	GLY34
A	LYS114
A	LEU156
A	ALA35
A	VAL39
A	ALA52
A	LYS54
A	ASP106
A	LEU107
A	MET108
A	ASP111

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 901

Chain	Residue
A	ARG70
A	ARG172
A	VAL173
A	MET333
A	GLU334
A	LEU335
A	ASP336

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 902

Chain	Residue
A	ARG148
A	ARG172
A	HIS178
A	HIS180
A	THR181
A	GLY182
A	PHE183
A	LEU184

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 903

Chain	Residue
A	VAL188
A	ALA189
A	THR190
B	ARG15

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 904

Chain	Residue
A	ARG191
A	LYS231
A	HIS232

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP B 900

Chain	Residue
B	GLY34
B	ALA35
B	VAL39
B	ALA52
B	LYS54
B	GLN105
B	ASP106
B	MET108
B	ASP111
B	LYS114
B	LEU156

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 901

Chain	Residue
B	ARG70
B	ARG172
B	VAL173
B	MET333
B	GLU334
B	LEU335
B	ASP336

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 B 902

Chain	Residue
B	ARG148
B	ARG172
B	HIS178
B	HIS180
B	THR181
B	GLY182
B	PHE183
B	LEU184

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 903

Chain	Residue
A	ARG15
B	VAL188
B	ALA189
B	THR190

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 B 904

Chain	Residue
B	ARG191
B	HIS232

---

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP C 900

Chain	Residue
C	GLY34
C	ALA35
C	VAL39
C	ALA52
C	LYS54
C	GLN105
C	ASP106
C	MET108
C	ASP111
C	LYS114
C	SER153
C	LEU156

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 901

Chain	Residue
C	ARG70
C	ARG172
C	VAL173
C	MET333
C	GLU334
C	LEU335
C	ASP336

---

site_id	BC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 902

Chain	Residue
C	ARG148
C	ARG172
C	HIS178
C	HIS180
C	THR181
C	GLY182
C	PHE183
C	LEU184

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 903

Chain	Residue
C	TYR187
C	VAL188
C	ALA189
C	THR190
D	ARG15

---

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 904

Chain	Residue
C	HIS232
C	ARG191
C	LYS231

---

site_id	BC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP D 900

Chain	Residue
D	GLY34
D	ALA35
D	VAL39
D	ALA52
D	LYS54
D	GLN105
D	ASP106
D	LEU107
D	MET108
D	ASP111
D	LYS114
D	SER153

---

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 D 901

Chain	Residue
D	ARG70
D	ARG172
D	VAL173
D	MET333
D	GLU334
D	LEU335
D	ASP336

---

site_id	BC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 902

Chain	Residue
D	ARG148
D	ARG172
D	HIS178
D	HIS180
D	THR181
D	GLY182
D	PHE183
D	LEU184

---

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 903

Chain	Residue
C	ARG15
D	VAL188
D	ALA189
D	THR190

---

site_id	CC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 904

Chain	Residue
D	ARG191
D	HIS232

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	25
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGAYGMVCsAydnvnkvrv.........AIKK

Chain	Residue	Details
A	ILE31-LYS55

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpsNLLL

Chain	Residue	Details
A	VAL145-LEU157

---

site_id	PS01351
Number of Residues	103
Details	MAPK MAP kinase signature. FehqtycqrtlREikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicyflyqilrglkyihsanvlh..........RDlKpsnlllnttC

Chain	Residue	Details
A	PHE59-CYS161

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1152
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	72
Details	DNA binding: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Motif: {"description":"TXY","evidences":[{"source":"PubMed","id":"18760948","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Motif: {"description":"Cytoplasmic retention motif","evidences":[{"source":"PubMed","id":"18760948","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	24
Details	Motif: {"description":"Nuclear translocation motif","evidences":[{"source":"PubMed","id":"18760948","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by SGK1","evidences":[{"source":"PubMed","id":"19447520","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by MAP2K1 and MAP2K2","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by MAP2K1 and MAP2K2","evidences":[{"source":"PubMed","id":"19053285","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19494114","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"19060905","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18760948","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---