4ISY

Crystal structure of IscS from Mycobacterium tuberculosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008483	molecular_function	transaminase activity
A	0016226	biological_process	iron-sulfur cluster assembly
A	0031071	molecular_function	cysteine desulfurase activity
A	0046872	molecular_function	metal ion binding
A	0051536	molecular_function	iron-sulfur cluster binding
B	0008483	molecular_function	transaminase activity
B	0016226	biological_process	iron-sulfur cluster assembly
B	0031071	molecular_function	cysteine desulfurase activity
B	0046872	molecular_function	metal ion binding
B	0051536	molecular_function	iron-sulfur cluster binding
C	0008483	molecular_function	transaminase activity
C	0016226	biological_process	iron-sulfur cluster assembly
C	0031071	molecular_function	cysteine desulfurase activity
C	0046872	molecular_function	metal ion binding
C	0051536	molecular_function	iron-sulfur cluster binding
D	0008483	molecular_function	transaminase activity
D	0016226	biological_process	iron-sulfur cluster assembly
D	0031071	molecular_function	cysteine desulfurase activity
D	0046872	molecular_function	metal ion binding
D	0051536	molecular_function	iron-sulfur cluster binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE GOL A 401

Chain	Residue
A	ARG92

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 402

Chain	Residue
A	GLY230
C	HIS101
C	ASP105
C	ALA328

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 403

Chain	Residue
C	ALA7
C	ALA8
C	GLY326
C	ARG355

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL B 401

Chain	Residue
B	ARG58
B	PRO59
B	SER60

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL B 402

Chain	Residue
B	GLU45
B	GLN232
B	GLU233
B	ARG234
B	HOH557
B	HOH558

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 401

Chain	Residue
C	ARG92
C	HIS117

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site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL C 402

Chain	Residue
A	ARG380
C	HIS89
D	ARG58

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 403

Chain	Residue
C	ARG83
C	THR222
C	HOH540
C	HOH541

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Cysteine persulfide intermediate => ECO:0000250|UniProtKB:P0A6B7, ECO:0000305|PubMed:24548275

Chain	Residue	Details
A	CYS329
B	CYS329
C	CYS329
D	CYS329

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0A6B9

Chain	Residue	Details
A	GLY68
C	GLN182
C	ALA202
C	THR240
D	GLY68
D	GLN182
D	ALA202
D	THR240
A	GLN182
A	ALA202
A	THR240
B	GLY68
B	GLN182
B	ALA202
B	THR240
C	GLY68

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O29689

Chain	Residue	Details
A	ASN154
B	ASN154
C	ASN154
D	ASN154

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: via persulfide group => ECO:0000250|UniProtKB:O29689

Chain	Residue	Details
A	CYS329
B	CYS329
C	CYS329
D	CYS329

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000250|UniProtKB:P0A6B9, ECO:0000305|PubMed:24548275

Chain	Residue	Details
A	LLP205
B	LLP205
C	LLP205
D	LLP205

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