4IRR
Crystal Structure of C.elegans Thymidylate Synthase in Complex with dUMP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE UMP A 401 |
| Chain | Residue |
| A | ARG51 |
| A | HIS258 |
| A | TYR260 |
| A | HOH523 |
| A | HOH645 |
| B | ARG177 |
| B | ARG178 |
| A | CYS197 |
| A | GLN216 |
| A | ARG217 |
| A | SER218 |
| A | GLY219 |
| A | ASP220 |
| A | GLY224 |
| A | ASN228 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE DTT A 402 |
| Chain | Residue |
| A | SER95 |
| A | ARG142 |
| A | HIS143 |
| A | SER156 |
| A | HOH627 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE DTT A 403 |
| Chain | Residue |
| A | LYS268 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE UMP B 401 |
| Chain | Residue |
| A | ARG177 |
| A | ARG178 |
| B | ARG51 |
| B | CYS197 |
| B | GLN216 |
| B | ARG217 |
| B | SER218 |
| B | GLY219 |
| B | ASP220 |
| B | GLY224 |
| B | VAL225 |
| B | ASN228 |
| B | HIS258 |
| B | TYR260 |
| B | DTT402 |
| B | HOH567 |
| B | HOH578 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE DTT B 402 |
| Chain | Residue |
| B | GLU89 |
| B | PHE227 |
| B | UMP401 |
| B | HOH570 |
| B | HOH622 |
| B | HOH658 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE DTT B 403 |
| Chain | Residue |
| A | TYR204 |
| A | SER211 |
| A | THR249 |
| B | THR46 |
| B | SER58 |
| B | PHE60 |
| B | HOH580 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriImsaWNpsdlgqmv.....LpPCHtmcQFyV |
| Chain | Residue | Details |
| A | ARG177-VAL205 |
