Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4IRE

Crystal structure of GLIC with mutations at the loop C region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMD A 401

Chain	Residue
A	ASP31
E	LMD401
E	LMD404
A	ILE233
A	ALA237
A	ILE240
A	THR244
A	ASN245
B	LYS33
B	THR244
C	LMD401

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PC1 A 402

Chain	Residue
A	ARG118
A	TYR194
A	LEU203
A	TYR254
A	ILE258
A	ASN307
A	PHE315

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PC1 A 403

Chain	Residue
A	MET252
A	LEU310

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXL A 404

Chain	Residue
A	ALA289
A	ARG293
A	ARG296
B	TYR278
B	GLU282

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXL A 405

Chain	Residue
A	PHE78
A	VAL81
A	ALA84
A	ARG85
E	ARG105

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE OXL A 406

Chain	Residue
A	PRO74
A	ILE76
A	ARG85

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT A 407

Chain	Residue
A	ARG77
A	ILE131
A	GLU181
E	PHE42

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT A 408

Chain	Residue
A	ARG133
E	ASN91

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PC1 B 401

Chain	Residue
B	ARG118
B	PHE121
B	TYR194
B	ILE198
B	TYR254
B	ASN307
B	PHE315

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PC1 B 402

Chain	Residue
B	ARG118
B	GLY316

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OXL B 403

Chain	Residue
B	ARG293
B	ARG296
C	TYR278
C	GLU282

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OXL B 404

Chain	Residue
A	SER220
B	TYR221
B	GLU222
B	HIS277

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 405

Chain	Residue
A	PHE42
A	ARG105
B	ARG77
B	ILE131
B	GLU181

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 406

Chain	Residue
A	ASN91
A	LEU103
B	ARG133
B	GLN177
B	ARG179

site_id	BC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE LMD C 401

Chain	Residue
A	ALA237
A	LMD401
B	LEU30
B	ASP31
B	ASP32
B	ILE233
B	ILE236
B	ALA237
B	ILE240
B	LEU241
B	THR244
B	ASN245
C	LYS33
C	THR244
C	LYS248
C	LMD402
C	HOH507
E	LMD401

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LMD C 402

Chain	Residue
C	ALA237
C	ILE240
C	ASN245
C	LMD401
D	THR244
E	LMD401
E	LMD402

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PC1 C 403

Chain	Residue
C	TYR254
C	ASN307
C	PHE315
C	HOH502

site_id	BC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PC1 C 404

Chain	Residue
C	TYR251
C	MET252
C	LEU313
C	PHE314

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OXL C 405

Chain	Residue
B	ARG105
C	ARG77
C	PHE78
C	VAL81
C	ASN83
C	ALA84
C	ARG85

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE OXL C 406

Chain	Residue
C	ILE73
C	PRO74
C	GLU75
C	ILE76
C	ARG85

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 407

Chain	Residue
B	PHE42
C	ARG77
C	ILE131
C	GLU181

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 408

Chain	Residue
B	ASN91
B	GLN101
C	ARG133
C	GLN177

site_id	CC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OXL D 501

Chain	Residue
C	ARG293
C	ARG296
D	TYR278
D	GLU282

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PC1 D 502

Chain	Residue
D	ARG118
D	TYR194
D	TYR254
D	ASN307
D	PHE315

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PC1 D 503

Chain	Residue
D	MET252
D	LEU313
D	PHE314

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OXL D 504

Chain	Residue
C	ARG105
D	ARG77
D	PHE78
D	VAL81
D	ALA84
D	ARG85

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OXL D 505

Chain	Residue
D	THR219
D	TYR221
D	HIS277
D	LYS280

site_id	DC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE OXL D 506

Chain	Residue
D	ASN40
D	ASP86
D	ASP88
D	ARG105
D	SER107
E	ASN83
E	ALA84
E	OXL408

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OXL D 507

Chain	Residue
D	TYR66
D	VAL89
D	VAL90
D	ASN91
D	ILE92
E	GLU75

site_id	DC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT D 508

Chain	Residue
C	PHE42
D	ARG77
D	ILE131
D	GLU181

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT D 509

Chain	Residue
C	ASN91
C	GLN101
D	ARG133
D	ARG179

site_id	DC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LMD E 401

Chain	Residue
A	LMD401
C	LMD401
C	LMD402
E	ILE233
E	LMD402
E	LMD404

site_id	DC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE LMD E 402

Chain	Residue
C	ALA237
C	LMD402
D	ALA237
D	ILE240
D	ASN245
E	LYS33
E	ILE240
E	THR244
E	LMD401
E	LMD404

site_id	DC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OXL E 403

Chain	Residue
D	ARG293
D	ARG296
E	TYR278
E	GLU282

site_id	DC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE LMD E 404

Chain	Residue
A	LYS33
A	THR244
A	LMD401
D	ALA237
E	ILE233
E	ALA237
E	ILE240
E	THR244
E	ASN245
E	LMD401
E	LMD402

site_id	DC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PC1 E 405

Chain	Residue
C	ASP55
C	VAL57
E	PHE121
E	GLU163
E	SER191
E	TYR194
E	ILE198
E	TYR254
E	ASN307

site_id	EC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PC1 E 406

Chain	Residue
E	MET252
E	PHE260

site_id	EC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OXL E 407

Chain	Residue
A	TYR278
E	ALA289
E	ARG293
E	ARG296

site_id	EC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OXL E 408

Chain	Residue
D	ARG105
D	OXL506
E	ARG77
E	PHE78
E	VAL81
E	ALA84
E	ARG85

site_id	EC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OXL E 409

Chain	Residue
E	PRO74
E	GLU75
E	ILE76
E	ARG85
E	TYR102
E	GLU104
E	HOH511

site_id	EC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE OXL E 410

Chain	Residue
D	SER220
E	TYR221
E	GLU222
E	HIS277

site_id	EC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT E 411

Chain	Residue
D	PHE42
D	ARG105
E	ARG77
E	ILE131
E	GLU181

site_id	EC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT E 412

Chain	Residue
D	ASN91
E	ARG133
E	GLN177
E	ARG179

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	990
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
A	GLN2-GLN193
E	ASN245-MET252
A	ASN245-MET252
B	GLN2-GLN193
B	ASN245-MET252
C	GLN2-GLN193
C	ASN245-MET252
D	GLN2-GLN193
D	ASN245-MET252
E	GLN2-GLN193

site_id	SWS_FT_FI2
Number of Residues	530
Details	TRANSMEM: Helical

Chain	Residue	Details
A	TYR194-PHE216
C	SER220-THR244
C	THR253-VAL281
C	PRO285-PHE317
D	TYR194-PHE216
D	SER220-THR244
D	THR253-VAL281
D	PRO285-PHE317
E	TYR194-PHE216
E	SER220-THR244
E	THR253-VAL281
A	SER220-THR244
E	PRO285-PHE317
A	THR253-VAL281
A	PRO285-PHE317
B	TYR194-PHE216
B	SER220-THR244
B	THR253-VAL281
B	PRO285-PHE317
C	TYR194-PHE216

site_id	SWS_FT_FI3
Number of Residues	20
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
A	TRP217-THR219
E	GLU282-GLN284
A	GLU282-GLN284
B	TRP217-THR219
B	GLU282-GLN284
C	TRP217-THR219
C	GLU282-GLN284
D	TRP217-THR219
D	GLU282-GLN284
E	TRP217-THR219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)