4IP9
Structure of native human serum amyloid A1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001664 | molecular_function | G protein-coupled receptor binding |
| A | 0001819 | biological_process | positive regulation of cytokine production |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005881 | cellular_component | cytoplasmic microtubule |
| A | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| A | 0030168 | biological_process | platelet activation |
| A | 0030593 | biological_process | neutrophil chemotaxis |
| A | 0032732 | biological_process | positive regulation of interleukin-1 production |
| A | 0045785 | biological_process | positive regulation of cell adhesion |
| A | 0048246 | biological_process | macrophage chemotaxis |
| A | 0048247 | biological_process | lymphocyte chemotaxis |
| A | 0050708 | biological_process | regulation of protein secretion |
| A | 0050728 | biological_process | negative regulation of inflammatory response |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071682 | cellular_component | endocytic vesicle lumen |
| B | 0001664 | molecular_function | G protein-coupled receptor binding |
| B | 0001819 | biological_process | positive regulation of cytokine production |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005881 | cellular_component | cytoplasmic microtubule |
| B | 0007204 | biological_process | positive regulation of cytosolic calcium ion concentration |
| B | 0030168 | biological_process | platelet activation |
| B | 0030593 | biological_process | neutrophil chemotaxis |
| B | 0032732 | biological_process | positive regulation of interleukin-1 production |
| B | 0045785 | biological_process | positive regulation of cell adhesion |
| B | 0048246 | biological_process | macrophage chemotaxis |
| B | 0048247 | biological_process | lymphocyte chemotaxis |
| B | 0050708 | biological_process | regulation of protein secretion |
| B | 0050728 | biological_process | negative regulation of inflammatory response |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071682 | cellular_component | endocytic vesicle lumen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE P4C A 201 |
| Chain | Residue |
| A | PHE11 |
| A | ARG15 |
| A | ARG15 |
| A | TRP18 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE P4C A 202 |
| Chain | Residue |
| A | ARG1 |
| A | PHE4 |
| A | SER5 |
| A | TRP18 |
| A | ARG25 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE P4C A 203 |
| Chain | Residue |
| A | TRP18 |
| A | ILE58 |
| A | P4C204 |
| B | P4C202 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE P4C A 204 |
| Chain | Residue |
| A | PHE4 |
| A | ARG62 |
| A | ILE65 |
| A | GLN66 |
| A | P4C203 |
| B | PHE4 |
| B | ALA61 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE P4C B 201 |
| Chain | Residue |
| B | ARG1 |
| B | PHE4 |
| B | SER5 |
| B | TRP18 |
| B | ARG25 |
| B | GLN66 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE P4C B 202 |
| Chain | Residue |
| A | P4C203 |
| B | PHE11 |
| B | ARG15 |
| B | TRP18 |
Functional Information from PROSITE/UniProt
| site_id | PS00992 |
| Number of Residues | 17 |
| Details | SAA Serum amyloid A proteins signature. ARGNYDAaKRGpGGvWA |
| Chain | Residue | Details |
| A | ALA38-ALA54 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | Propeptide: {"description":"Often cleaved during amyloidogenesis","featureId":"PRO_0000031582"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 52 |
| Details | Region: {"description":"Important for amyloid formation; forms amyloid fibrils in vitro"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 48 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N4,N4-dimethylasparagine","evidences":[{"source":"PubMed","id":"8783012","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
