4IP9

Structure of native human serum amyloid A1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001664	molecular_function	G protein-coupled receptor binding
A	0001819	biological_process	positive regulation of cytokine production
A	0005576	cellular_component	extracellular region
A	0005881	cellular_component	cytoplasmic microtubule
A	0006953	biological_process	acute-phase response
A	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
A	0008201	molecular_function	heparin binding
A	0030168	biological_process	platelet activation
A	0030593	biological_process	neutrophil chemotaxis
A	0032732	biological_process	positive regulation of interleukin-1 production
A	0034364	cellular_component	high-density lipoprotein particle
A	0045785	biological_process	positive regulation of cell adhesion
A	0048246	biological_process	macrophage chemotaxis
A	0048247	biological_process	lymphocyte chemotaxis
A	0050708	biological_process	regulation of protein secretion
A	0050728	biological_process	negative regulation of inflammatory response
A	0070062	cellular_component	extracellular exosome
A	0071682	cellular_component	endocytic vesicle lumen
B	0001664	molecular_function	G protein-coupled receptor binding
B	0001819	biological_process	positive regulation of cytokine production
B	0005576	cellular_component	extracellular region
B	0005881	cellular_component	cytoplasmic microtubule
B	0006953	biological_process	acute-phase response
B	0007204	biological_process	positive regulation of cytosolic calcium ion concentration
B	0008201	molecular_function	heparin binding
B	0030168	biological_process	platelet activation
B	0030593	biological_process	neutrophil chemotaxis
B	0032732	biological_process	positive regulation of interleukin-1 production
B	0034364	cellular_component	high-density lipoprotein particle
B	0045785	biological_process	positive regulation of cell adhesion
B	0048246	biological_process	macrophage chemotaxis
B	0048247	biological_process	lymphocyte chemotaxis
B	0050708	biological_process	regulation of protein secretion
B	0050728	biological_process	negative regulation of inflammatory response
B	0070062	cellular_component	extracellular exosome
B	0071682	cellular_component	endocytic vesicle lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE P4C A 201

Chain	Residue
A	PHE11
A	ARG15
A	ARG15
A	TRP18

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE P4C A 202

Chain	Residue
A	ARG1
A	PHE4
A	SER5
A	TRP18
A	ARG25

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE P4C A 203

Chain	Residue
A	TRP18
A	ILE58
A	P4C204
B	P4C202

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE P4C A 204

Chain	Residue
A	PHE4
A	ARG62
A	ILE65
A	GLN66
A	P4C203
B	PHE4
B	ALA61

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE P4C B 201

Chain	Residue
B	ARG1
B	PHE4
B	SER5
B	TRP18
B	ARG25
B	GLN66

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE P4C B 202

Chain	Residue
A	P4C203
B	PHE11
B	ARG15
B	TRP18

---

Functional Information from PROSITE/UniProt

site_id	PS00992
Number of Residues	17
Details	SAA Serum amyloid A proteins signature. ARGNYDAaKRGpGGvWA

Chain	Residue	Details
A	ALA38-ALA54

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	54
Details	Propeptide: {"description":"Often cleaved during amyloidogenesis","featureId":"PRO_0000031582"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	52
Details	Region: {"description":"Important for amyloid formation; forms amyloid fibrils in vitro"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N4,N4-dimethylasparagine","evidences":[{"source":"PubMed","id":"8783012","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---