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4IP8

Structure of human serum amyloid A1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001664molecular_functionG protein-coupled receptor binding
A0001819biological_processpositive regulation of cytokine production
A0005576cellular_componentextracellular region
A0005881cellular_componentcytoplasmic microtubule
A0006953biological_processacute-phase response
A0007204biological_processpositive regulation of cytosolic calcium ion concentration
A0008201molecular_functionheparin binding
A0030168biological_processplatelet activation
A0030593biological_processneutrophil chemotaxis
A0032732biological_processpositive regulation of interleukin-1 production
A0034364cellular_componenthigh-density lipoprotein particle
A0045785biological_processpositive regulation of cell adhesion
A0048246biological_processmacrophage chemotaxis
A0048247biological_processlymphocyte chemotaxis
A0050708biological_processregulation of protein secretion
A0050728biological_processnegative regulation of inflammatory response
A0070062cellular_componentextracellular exosome
A0071682cellular_componentendocytic vesicle lumen
B0001664molecular_functionG protein-coupled receptor binding
B0001819biological_processpositive regulation of cytokine production
B0005576cellular_componentextracellular region
B0005881cellular_componentcytoplasmic microtubule
B0006953biological_processacute-phase response
B0007204biological_processpositive regulation of cytosolic calcium ion concentration
B0008201molecular_functionheparin binding
B0030168biological_processplatelet activation
B0030593biological_processneutrophil chemotaxis
B0032732biological_processpositive regulation of interleukin-1 production
B0034364cellular_componenthigh-density lipoprotein particle
B0045785biological_processpositive regulation of cell adhesion
B0048246biological_processmacrophage chemotaxis
B0048247biological_processlymphocyte chemotaxis
B0050708biological_processregulation of protein secretion
B0050728biological_processnegative regulation of inflammatory response
B0070062cellular_componentextracellular exosome
B0071682cellular_componentendocytic vesicle lumen
C0001664molecular_functionG protein-coupled receptor binding
C0001819biological_processpositive regulation of cytokine production
C0005576cellular_componentextracellular region
C0005881cellular_componentcytoplasmic microtubule
C0006953biological_processacute-phase response
C0007204biological_processpositive regulation of cytosolic calcium ion concentration
C0008201molecular_functionheparin binding
C0030168biological_processplatelet activation
C0030593biological_processneutrophil chemotaxis
C0032732biological_processpositive regulation of interleukin-1 production
C0034364cellular_componenthigh-density lipoprotein particle
C0045785biological_processpositive regulation of cell adhesion
C0048246biological_processmacrophage chemotaxis
C0048247biological_processlymphocyte chemotaxis
C0050708biological_processregulation of protein secretion
C0050728biological_processnegative regulation of inflammatory response
C0070062cellular_componentextracellular exosome
C0071682cellular_componentendocytic vesicle lumen
D0001664molecular_functionG protein-coupled receptor binding
D0001819biological_processpositive regulation of cytokine production
D0005576cellular_componentextracellular region
D0005881cellular_componentcytoplasmic microtubule
D0006953biological_processacute-phase response
D0007204biological_processpositive regulation of cytosolic calcium ion concentration
D0008201molecular_functionheparin binding
D0030168biological_processplatelet activation
D0030593biological_processneutrophil chemotaxis
D0032732biological_processpositive regulation of interleukin-1 production
D0034364cellular_componenthigh-density lipoprotein particle
D0045785biological_processpositive regulation of cell adhesion
D0048246biological_processmacrophage chemotaxis
D0048247biological_processlymphocyte chemotaxis
D0050708biological_processregulation of protein secretion
D0050728biological_processnegative regulation of inflammatory response
D0070062cellular_componentextracellular exosome
D0071682cellular_componentendocytic vesicle lumen
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 A 201
ChainResidue
AARG15
AARG47
DGLU102

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE P4C A 202
ChainResidue
AARG62
AILE65
AP4C203

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE P4C A 203
ChainResidue
AARG62
AP4C202
AMET17
ATYR21
AHIS37

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE P4C A 204
ChainResidue
ATRP53
BSER2

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE SO4 B 201
ChainResidue
BARG15
BARG47
CGLU102

site_idAC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE P4C B 202
ChainResidue
ASER2
BTRP53

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE P4C B 203
ChainResidue
BMET17
BTYR21
BHIS37
BARG62

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 C 201
ChainResidue
CARG15
CARG47

site_idAC9
Number of Residues1
DetailsBINDING SITE FOR RESIDUE P4C C 202
ChainResidue
CTRP53

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE P4C C 203
ChainResidue
CTYR21
CARG62
CP4C204

site_idBC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE P4C C 204
ChainResidue
CMET17
CTYR21
CMET24
CHIS37
CARG62
CP4C203

site_idBC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE P4C C 205
ChainResidue
CTYR42
CGLY89

site_idBC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE SO4 D 201
ChainResidue
DARG15
DARG47

site_idBC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE P4C D 202
ChainResidue
CSER2
DTRP53

site_idBC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE P4C D 203
ChainResidue
DMET17
DMET24
DHIS37
DILE58
DARG62

Functional Information from PROSITE/UniProt
site_idPS00992
Number of Residues17
DetailsSAA Serum amyloid A proteins signature. ARGNYDAaKRGpGGvWA
ChainResidueDetails
AALA38-ALA54

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: N4,N4-dimethylasparagine => ECO:0000305|PubMed:8783012
ChainResidueDetails
AASN83
BASN83
CASN83
DASN83

224931

PDB entries from 2024-09-11

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