4IP0
X-Ray Structure of the Complex Uridine Phosphorylase from Vibrio cholerae with Phosphate Ion at 1.29 A Resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0044206 | biological_process | UMP salvage |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0044206 | biological_process | UMP salvage |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0009166 | biological_process | nucleotide catabolic process |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0044206 | biological_process | UMP salvage |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0009166 | biological_process | nucleotide catabolic process |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0044206 | biological_process | UMP salvage |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009164 | biological_process | nucleoside catabolic process |
| E | 0009166 | biological_process | nucleotide catabolic process |
| E | 0016757 | molecular_function | glycosyltransferase activity |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0044206 | biological_process | UMP salvage |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009164 | biological_process | nucleoside catabolic process |
| F | 0009166 | biological_process | nucleotide catabolic process |
| F | 0016757 | molecular_function | glycosyltransferase activity |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0044206 | biological_process | UMP salvage |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 301 |
| Chain | Residue |
| A | GLU48 |
| A | ILE68 |
| A | SER72 |
| B | GLU48 |
| B | ILE68 |
| B | SER72 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO A 302 |
| Chain | Residue |
| C | GLN31 |
| A | HOH578 |
| A | HOH670 |
| A | HOH747 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE PO4 B 301 |
| Chain | Residue |
| B | ARG86 |
| B | HOH516 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PO4 B 302 |
| Chain | Residue |
| A | ARG47 |
| B | GLY25 |
| B | ARG29 |
| B | ARG90 |
| B | VAL91 |
| B | GLY92 |
| B | THR93 |
| B | HOH439 |
| B | HOH489 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 303 |
| Chain | Residue |
| B | LYS140 |
| B | GLN144 |
| B | HOH604 |
| B | HOH626 |
| B | HOH655 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 304 |
| Chain | Residue |
| B | ARG177 |
| B | HOH457 |
| B | HOH505 |
| D | ARG177 |
| F | ARG177 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO B 305 |
| Chain | Residue |
| A | GLY92 |
| A | THR93 |
| A | HOH550 |
| A | HOH564 |
| B | ARG47 |
| B | HOH634 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EOH B 306 |
| Chain | Residue |
| B | HOH413 |
| B | HOH437 |
| B | HOH438 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 C 301 |
| Chain | Residue |
| C | GLY25 |
| C | ARG29 |
| C | ARG90 |
| C | VAL91 |
| C | GLY92 |
| C | THR93 |
| C | HOH442 |
| C | HOH573 |
| C | HOH581 |
| D | ARG47 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL C 302 |
| Chain | Residue |
| C | GLY95 |
| C | ARG167 |
| C | ILE220 |
| C | EDO303 |
| site_id | BC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE EDO C 303 |
| Chain | Residue |
| C | THR94 |
| C | GLY95 |
| C | PHE161 |
| C | GLN165 |
| C | PHE194 |
| C | GLU195 |
| C | MET196 |
| C | CL302 |
| C | HOH524 |
| C | HOH573 |
| C | HOH579 |
| C | HOH580 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE EDO C 304 |
| Chain | Residue |
| C | ARG239 |
| C | LYS242 |
| C | HOH703 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K D 301 |
| Chain | Residue |
| C | GLU48 |
| C | ILE68 |
| C | SER72 |
| D | GLU48 |
| D | ILE68 |
| D | SER72 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 D 302 |
| Chain | Residue |
| C | HOH458 |
| C | HOH517 |
| D | HIS46 |
| D | HOH443 |
| D | HOH533 |
| D | HOH586 |
| D | HOH676 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA E 301 |
| Chain | Residue |
| E | GLU48 |
| E | ILE68 |
| E | SER72 |
| F | GLU48 |
| F | ILE68 |
| F | SER72 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 E 302 |
| Chain | Residue |
| E | ARG90 |
| E | GLY92 |
| E | THR93 |
| E | HOH441 |
| E | HOH581 |
| E | HOH627 |
| E | HOH731 |
| F | ARG47 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 E 303 |
| Chain | Residue |
| E | ARG86 |
| E | HOH663 |
| E | HOH687 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO E 304 |
| Chain | Residue |
| E | GLU166 |
| E | MET183 |
| E | ARG222 |
| E | HOH693 |
| E | HOH706 |
| site_id | CC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PO4 F 301 |
| Chain | Residue |
| E | ARG47 |
| F | GLY25 |
| F | ARG29 |
| F | ARG90 |
| F | VAL91 |
| F | GLY92 |
| F | THR93 |
| F | HOH467 |
| F | HOH575 |
| F | HOH585 |
| site_id | CC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 F 302 |
| Chain | Residue |
| F | LYS140 |
| F | GLN144 |
| F | HOH520 |
| F | HOH523 |
| F | HOH527 |
| F | HOH588 |
| F | HOH643 |
| F | HOH658 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CL F 303 |
| Chain | Residue |
| F | GLY95 |
| F | ARG167 |
| F | ILE220 |
| F | EDO304 |
| site_id | CC4 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE EDO F 304 |
| Chain | Residue |
| F | THR94 |
| F | GLY95 |
| F | GLN165 |
| F | PHE194 |
| F | GLU195 |
| F | MET196 |
| F | CL303 |
| F | HOH575 |
| F | HOH577 |
| F | HOH578 |
| F | HOH579 |
| F | HOH585 |
| site_id | CC5 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE EDO F 305 |
| Chain | Residue |
| A | SER207 |
| A | SER208 |
| A | GLY209 |
| B | ARG174 |
| F | ASP188 |
| F | MET189 |
| F | GLY190 |
| F | HOH425 |
| F | HOH716 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| Chain | Residue | Details |
| A | SER65-LEU80 |
