4IMJ

Novel Modifications on C-terminal Domain of RNA Polymerase II can Fine-tune the Phosphatase Activity of Ssu72

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0005634	cellular_component	nucleus
B	0005847	cellular_component	mRNA cleavage and polyadenylation specificity factor complex
B	0006338	biological_process	chromatin remodeling
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006369	biological_process	termination of RNA polymerase II transcription
B	0006397	biological_process	mRNA processing
B	0008420	molecular_function	RNA polymerase II CTD heptapeptide repeat phosphatase activity
B	0016791	molecular_function	phosphatase activity
B	0017018	molecular_function	myosin phosphatase activity
B	0031124	biological_process	mRNA 3'-end processing
B	0033192	molecular_function	calmodulin-dependent protein phosphatase activity
B	0140791	molecular_function	histone H2AXS140 phosphatase activity
B	0180004	molecular_function	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
B	0180005	molecular_function	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
B	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
B	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
B	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
B	1990439	molecular_function	MAP kinase serine/threonine phosphatase activity
D	0004721	molecular_function	phosphoprotein phosphatase activity
D	0004722	molecular_function	protein serine/threonine phosphatase activity
D	0005634	cellular_component	nucleus
D	0005847	cellular_component	mRNA cleavage and polyadenylation specificity factor complex
D	0006338	biological_process	chromatin remodeling
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006369	biological_process	termination of RNA polymerase II transcription
D	0006397	biological_process	mRNA processing
D	0008420	molecular_function	RNA polymerase II CTD heptapeptide repeat phosphatase activity
D	0016791	molecular_function	phosphatase activity
D	0017018	molecular_function	myosin phosphatase activity
D	0031124	biological_process	mRNA 3'-end processing
D	0033192	molecular_function	calmodulin-dependent protein phosphatase activity
D	0140791	molecular_function	histone H2AXS140 phosphatase activity
D	0180004	molecular_function	RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity
D	0180005	molecular_function	RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity
D	0180006	molecular_function	RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity
D	0180007	molecular_function	RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity
D	0180008	molecular_function	RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity
D	1990439	molecular_function	MAP kinase serine/threonine phosphatase activity
F	0003677	molecular_function	DNA binding
F	0006366	biological_process	transcription by RNA polymerase II

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 B 201

Chain	Residue
B	ASP13
B	SER14
B	SER15
B	ASN16
B	MET17
B	ASN18
B	ARG19
B	ASN144

---

Functional Information from PROSITE/UniProt

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPS

Chain	Residue	Details
F	TYR-6-SER0
F	TYR1-SER7

---