4IMJ
Novel Modifications on C-terminal Domain of RNA Polymerase II can Fine-tune the Phosphatase Activity of Ssu72
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| B | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0005847 | cellular_component | mRNA cleavage and polyadenylation specificity factor complex |
| B | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| B | 0006369 | biological_process | termination of RNA polymerase II transcription |
| B | 0006397 | biological_process | mRNA processing |
| B | 0008420 | molecular_function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016791 | molecular_function | phosphatase activity |
| B | 0031124 | biological_process | mRNA 3'-end processing |
| D | 0004721 | molecular_function | phosphoprotein phosphatase activity |
| D | 0004722 | molecular_function | protein serine/threonine phosphatase activity |
| D | 0005634 | cellular_component | nucleus |
| D | 0005847 | cellular_component | mRNA cleavage and polyadenylation specificity factor complex |
| D | 0006357 | biological_process | regulation of transcription by RNA polymerase II |
| D | 0006369 | biological_process | termination of RNA polymerase II transcription |
| D | 0006397 | biological_process | mRNA processing |
| D | 0008420 | molecular_function | RNA polymerase II CTD heptapeptide repeat phosphatase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016791 | molecular_function | phosphatase activity |
| D | 0031124 | biological_process | mRNA 3'-end processing |
| F | 0003677 | molecular_function | DNA binding |
| F | 0006366 | biological_process | transcription by RNA polymerase II |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 B 201 |
| Chain | Residue |
| B | ASP13 |
| B | SER14 |
| B | SER15 |
| B | ASN16 |
| B | MET17 |
| B | ASN18 |
| B | ARG19 |
| B | ASN144 |
Functional Information from PROSITE/UniProt
| site_id | PS00115 |
| Number of Residues | 7 |
| Details | RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPS |
| Chain | Residue | Details |
| F | TYR-6-SER0 | |
| F | TYR1-SER7 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 35 |
| Details | Repeat: {"description":"HEAT 1","evidences":[{"source":"PubMed","id":"19576221","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 68 |
| Details | Repeat: {"description":"HEAT 2","evidences":[{"source":"PubMed","id":"19576221","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 84 |
| Details | Repeat: {"description":"HEAT 3","evidences":[{"source":"PubMed","id":"19576221","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"HEAT 4","evidences":[{"source":"PubMed","id":"19576221","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 78 |
| Details | Repeat: {"description":"HEAT 5","evidences":[{"source":"PubMed","id":"19576221","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
