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4IM7

Crystal structure of fructuronate reductase (ydfI) from E. coli CFT073 (EFI TARGET EFI-506389) complexed with NADH and D-mannonate

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0016491molecular_functionoxidoreductase activity
A0016616molecular_functionoxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A0019594biological_processmannitol metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE CS2 A 501
ChainResidue
AASN185
ANAI502
AHOH698
AHOH713
AHOH920
AASP224
AARG225
ALYS289
AASN294
AHIS297
AHIS362
ALYS374
AARG378

site_idAC2
Number of Residues28
DetailsBINDING SITE FOR RESIDUE NAI A 502
ChainResidue
AGLY29
APHE30
AGLY31
AALA32
APHE33
AASN59
AILE61
AGLY62
ATHR124
AILE125
ATHR126
AGLY129
AASP184
AASN185
AVAL223
AARG225
AVAL227
ACS2501
AHOH614
AHOH620
AHOH627
AHOH645
AHOH710
AHOH734
AHOH771
AHOH822
AHOH933
AHOH940

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 503
ChainResidue
ATYR305
AGLN310
AARG363
AHOH619
AHOH1039

Functional Information from PROSITE/UniProt
site_idPS00974
Number of Residues13
DetailsMANNITOL_DHGENASE Mannitol dehydrogenases signature. VtFpsTmVDRIvP
ChainResidueDetails
AVAL216-PRO228

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PDB entries from 2024-10-30

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