4ILW

Complex of matrix metalloproteinase-10 catalytic domain (MMP-10cd) with tissue inhibitor of metalloproteinases-2 (TIMP-2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0002020	molecular_function	protease binding
A	0004857	molecular_function	enzyme inhibitor activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0008191	molecular_function	metalloendopeptidase inhibitor activity
A	0008270	molecular_function	zinc ion binding
A	0009725	biological_process	response to hormone
A	0030414	molecular_function	peptidase inhibitor activity
A	0031012	cellular_component	extracellular matrix
A	0034097	biological_process	response to cytokine
A	0034774	cellular_component	secretory granule lumen
A	0035580	cellular_component	specific granule lumen
A	0045861	biological_process	negative regulation of proteolysis
A	0046872	molecular_function	metal ion binding
A	0051045	biological_process	negative regulation of membrane protein ectodomain proteolysis
A	0140678	molecular_function	molecular function inhibitor activity
A	1904724	cellular_component	tertiary granule lumen
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	1905049	biological_process	negative regulation of metallopeptidase activity
B	0002020	molecular_function	protease binding
B	0004857	molecular_function	enzyme inhibitor activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0008191	molecular_function	metalloendopeptidase inhibitor activity
B	0008270	molecular_function	zinc ion binding
B	0009725	biological_process	response to hormone
B	0030414	molecular_function	peptidase inhibitor activity
B	0031012	cellular_component	extracellular matrix
B	0034097	biological_process	response to cytokine
B	0034774	cellular_component	secretory granule lumen
B	0035580	cellular_component	specific granule lumen
B	0045861	biological_process	negative regulation of proteolysis
B	0046872	molecular_function	metal ion binding
B	0051045	biological_process	negative regulation of membrane protein ectodomain proteolysis
B	0140678	molecular_function	molecular function inhibitor activity
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	1905049	biological_process	negative regulation of metallopeptidase activity
D	0004222	molecular_function	metalloendopeptidase activity
D	0006508	biological_process	proteolysis
D	0008237	molecular_function	metallopeptidase activity
D	0008270	molecular_function	zinc ion binding
D	0031012	cellular_component	extracellular matrix
F	0004222	molecular_function	metalloendopeptidase activity
F	0006508	biological_process	proteolysis
F	0008237	molecular_function	metallopeptidase activity
F	0008270	molecular_function	zinc ion binding
F	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 301

Chain	Residue
A	CYS1
D	HIS217
D	HIS221
D	HIS227

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN D 302

Chain	Residue
D	HIS167
D	ASP169
D	HIS182
D	HIS195

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 303

Chain	Residue
D	GLY175
D	GLY177
D	SER179
D	ASP197
D	GLU200
D	ASP174

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA D 304

Chain	Residue
D	ASP157
D	GLY189
D	TYR191
D	ASP193
D	HOH410

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA D 305

Chain	Residue
D	ASP123
D	ASP198
D	GLU200
D	HOH425

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 301

Chain	Residue
B	CYS1
F	HIS217
F	HIS221
F	HIS227

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN F 302

Chain	Residue
F	HIS167
F	ASP169
F	HIS182
F	HIS195

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA F 303

Chain	Residue
F	ASP174
F	GLY175
F	GLY177
F	SER179
F	ASP197
F	GLU200

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA F 304

Chain	Residue
F	ASP157
F	GLY189
F	TYR191
F	ASP193

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA F 305

Chain	Residue
F	ASP123
F	ASP198
F	GLU200

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL

Chain	Residue	Details
D	VAL214-LEU223

---

site_id	PS00288
Number of Residues	13
Details	TIMP Tissue inhibitors of metalloproteinases signature. CsCsPvHPQqaFC

Chain	Residue	Details
A	CYS1-CYS13

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	250
Details	Domain: {"description":"NTR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00295","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"Involved in metalloproteinase-binding","evidences":[{"source":"PubMed","id":"24073280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ILW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"24073280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ILW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Site: {"description":"Involved in metalloproteinase-binding","evidences":[{"source":"PubMed","id":"24073280","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ILW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15095982","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	14
Details	Binding site: {}

Chain

Residue

Details

---