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4IL1

Crystal Structure of the Rat Calcineurin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000086biological_processG2/M transition of mitotic cell cycle
A0000922cellular_componentspindle pole
A0001569biological_processbranching involved in blood vessel morphogenesis
A0001837biological_processepithelial to mesenchymal transition
A0001975biological_processresponse to amphetamine
A0002027biological_processregulation of heart rate
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
A0005246molecular_functioncalcium channel regulator activity
A0005509molecular_functioncalcium ion binding
A0005513biological_processdetection of calcium ion
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005876cellular_componentspindle microtubule
A0005886cellular_componentplasma membrane
A0005955cellular_componentcalcineurin complex
A0006470biological_processprotein dephosphorylation
A0006606biological_processprotein import into nucleus
A0006816biological_processcalcium ion transport
A0007507biological_processheart development
A0008076cellular_componentvoltage-gated potassium channel complex
A0008179molecular_functionadenylate cyclase binding
A0008544biological_processepidermis development
A0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010613biological_processpositive regulation of cardiac muscle hypertrophy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010856molecular_functionadenylate cyclase activator activity
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0014044biological_processSchwann cell development
A0014883biological_processtransition between fast and slow fiber
A0014898biological_processcardiac muscle hypertrophy in response to stress
A0016018molecular_functioncyclosporin A binding
A0016240biological_processautophagosome membrane docking
A0016311biological_processdephosphorylation
A0016787molecular_functionhydrolase activity
A0017018molecular_functionmyosin phosphatase activity
A0019722biological_processcalcium-mediated signaling
A0019855molecular_functioncalcium channel inhibitor activity
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0019902molecular_functionphosphatase binding
A0019904molecular_functionprotein domain specific binding
A0022011biological_processmyelination in peripheral nervous system
A0023057biological_processnegative regulation of signaling
A0030017cellular_componentsarcomere
A0030018cellular_componentZ disc
A0030216biological_processkeratinocyte differentiation
A0030235molecular_functionnitric-oxide synthase regulator activity
A0030335biological_processpositive regulation of cell migration
A0030426cellular_componentgrowth cone
A0030672cellular_componentsynaptic vesicle membrane
A0031432molecular_functiontitin binding
A0031514cellular_componentmotile cilium
A0031800molecular_functiontype 3 metabotropic glutamate receptor binding
A0031966cellular_componentmitochondrial membrane
A0032465biological_processregulation of cytokinesis
A0032991cellular_componentprotein-containing complex
A0033173biological_processcalcineurin-NFAT signaling cascade
A0033192molecular_functioncalmodulin-dependent protein phosphatase activity
A0033555biological_processmulticellular organismal response to stress
A0034504biological_processprotein localization to nucleus
A0034704cellular_componentcalcium channel complex
A0035307biological_processpositive regulation of protein dephosphorylation
A0035458biological_processcellular response to interferon-beta
A0036057cellular_componentslit diaphragm
A0042104biological_processpositive regulation of activated T cell proliferation
A0042383cellular_componentsarcolemma
A0042995cellular_componentcell projection
A0043197cellular_componentdendritic spine
A0043209cellular_componentmyelin sheath
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0043548molecular_functionphosphatidylinositol 3-kinase binding
A0044305cellular_componentcalyx of Held
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045669biological_processpositive regulation of osteoblast differentiation
A0045672biological_processpositive regulation of osteoclast differentiation
A0045785biological_processpositive regulation of cell adhesion
A0045807biological_processpositive regulation of endocytosis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0045955biological_processnegative regulation of calcium ion-dependent exocytosis
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046676biological_processnegative regulation of insulin secretion
A0046872molecular_functionmetal ion binding
A0046878biological_processpositive regulation of saliva secretion
A0046983molecular_functionprotein dimerization activity
A0048306molecular_functioncalcium-dependent protein binding
A0048741biological_processskeletal muscle fiber development
A0048813biological_processdendrite morphogenesis
A0050774biological_processnegative regulation of dendrite morphogenesis
A0050804biological_processmodulation of chemical synaptic transmission
A0050998molecular_functionnitric-oxide synthase binding
A0051117molecular_functionATPase binding
A0051592biological_processresponse to calcium ion
A0055117biological_processregulation of cardiac muscle contraction
A0060079biological_processexcitatory postsynaptic potential
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0060487biological_processlung epithelial cell differentiation
A0061006biological_processregulation of cell proliferation involved in kidney morphogenesis
A0071333biological_processcellular response to glucose stimulus
A0071346biological_processcellular response to type II interferon
A0072542molecular_functionprotein phosphatase activator activity
A0090150biological_processestablishment of protein localization to membrane
A0090151biological_processestablishment of protein localization to mitochondrial membrane
A0090193biological_processpositive regulation of glomerulus development
A0097205biological_processrenal filtration
A0097225cellular_componentsperm midpiece
A0097720biological_processcalcineurin-mediated signaling
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098686cellular_componenthippocampal mossy fiber to CA3 synapse
A0098688cellular_componentparallel fiber to Purkinje cell synapse
A0098693biological_processregulation of synaptic vesicle cycle
A0098794cellular_componentpostsynapse
A0098901biological_processregulation of cardiac muscle cell action potential
A0098978cellular_componentglutamatergic synapse
A0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0099523cellular_componentpresynaptic cytosol
A0099524cellular_componentpostsynaptic cytosol
A0110062biological_processnegative regulation of angiotensin-activated signaling pathway
A0140056biological_processorganelle localization by membrane tethering
A0140238biological_processpresynaptic endocytosis
A1900242biological_processregulation of synaptic vesicle endocytosis
A1902494cellular_componentcatalytic complex
A1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
A1905205biological_processpositive regulation of connective tissue replacement
A1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
A2000300biological_processregulation of synaptic vesicle exocytosis
B0000082biological_processG1/S transition of mitotic cell cycle
B0000086biological_processG2/M transition of mitotic cell cycle
B0000922cellular_componentspindle pole
B0001569biological_processbranching involved in blood vessel morphogenesis
B0001837biological_processepithelial to mesenchymal transition
B0001975biological_processresponse to amphetamine
B0002027biological_processregulation of heart rate
B0004721molecular_functionphosphoprotein phosphatase activity
B0004722molecular_functionprotein serine/threonine phosphatase activity
B0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
B0005246molecular_functioncalcium channel regulator activity
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005876cellular_componentspindle microtubule
B0005886cellular_componentplasma membrane
B0005955cellular_componentcalcineurin complex
B0006470biological_processprotein dephosphorylation
B0006606biological_processprotein import into nucleus
B0006816biological_processcalcium ion transport
B0007507biological_processheart development
B0008076cellular_componentvoltage-gated potassium channel complex
B0008179molecular_functionadenylate cyclase binding
B0008544biological_processepidermis development
B0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010613biological_processpositive regulation of cardiac muscle hypertrophy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010856molecular_functionadenylate cyclase activator activity
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0014044biological_processSchwann cell development
B0014883biological_processtransition between fast and slow fiber
B0014898biological_processcardiac muscle hypertrophy in response to stress
B0016018molecular_functioncyclosporin A binding
B0016240biological_processautophagosome membrane docking
B0016311biological_processdephosphorylation
B0016787molecular_functionhydrolase activity
B0017018molecular_functionmyosin phosphatase activity
B0019722biological_processcalcium-mediated signaling
B0019855molecular_functioncalcium channel inhibitor activity
B0019899molecular_functionenzyme binding
B0019901molecular_functionprotein kinase binding
B0019902molecular_functionphosphatase binding
B0019904molecular_functionprotein domain specific binding
B0022011biological_processmyelination in peripheral nervous system
B0023057biological_processnegative regulation of signaling
B0030017cellular_componentsarcomere
B0030018cellular_componentZ disc
B0030216biological_processkeratinocyte differentiation
B0030235molecular_functionnitric-oxide synthase regulator activity
B0030335biological_processpositive regulation of cell migration
B0030426cellular_componentgrowth cone
B0030672cellular_componentsynaptic vesicle membrane
B0031432molecular_functiontitin binding
B0031514cellular_componentmotile cilium
B0031800molecular_functiontype 3 metabotropic glutamate receptor binding
B0031966cellular_componentmitochondrial membrane
B0032465biological_processregulation of cytokinesis
B0032991cellular_componentprotein-containing complex
B0033173biological_processcalcineurin-NFAT signaling cascade
B0033192molecular_functioncalmodulin-dependent protein phosphatase activity
B0033555biological_processmulticellular organismal response to stress
B0034504biological_processprotein localization to nucleus
B0034704cellular_componentcalcium channel complex
B0035307biological_processpositive regulation of protein dephosphorylation
B0035458biological_processcellular response to interferon-beta
B0036057cellular_componentslit diaphragm
B0042104biological_processpositive regulation of activated T cell proliferation
B0042383cellular_componentsarcolemma
B0042995cellular_componentcell projection
B0043197cellular_componentdendritic spine
B0043209cellular_componentmyelin sheath
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0043548molecular_functionphosphatidylinositol 3-kinase binding
B0044305cellular_componentcalyx of Held
B0044325molecular_functiontransmembrane transporter binding
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0045669biological_processpositive regulation of osteoblast differentiation
B0045672biological_processpositive regulation of osteoclast differentiation
B0045785biological_processpositive regulation of cell adhesion
B0045807biological_processpositive regulation of endocytosis
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0045955biological_processnegative regulation of calcium ion-dependent exocytosis
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046676biological_processnegative regulation of insulin secretion
B0046872molecular_functionmetal ion binding
B0046878biological_processpositive regulation of saliva secretion
B0046983molecular_functionprotein dimerization activity
B0048306molecular_functioncalcium-dependent protein binding
B0048741biological_processskeletal muscle fiber development
B0048813biological_processdendrite morphogenesis
B0050774biological_processnegative regulation of dendrite morphogenesis
B0050804biological_processmodulation of chemical synaptic transmission
B0050998molecular_functionnitric-oxide synthase binding
B0051117molecular_functionATPase binding
B0051592biological_processresponse to calcium ion
B0055117biological_processregulation of cardiac muscle contraction
B0060079biological_processexcitatory postsynaptic potential
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0060487biological_processlung epithelial cell differentiation
B0061006biological_processregulation of cell proliferation involved in kidney morphogenesis
B0071333biological_processcellular response to glucose stimulus
B0071346biological_processcellular response to type II interferon
B0072542molecular_functionprotein phosphatase activator activity
B0090150biological_processestablishment of protein localization to membrane
B0090151biological_processestablishment of protein localization to mitochondrial membrane
B0090193biological_processpositive regulation of glomerulus development
B0097205biological_processrenal filtration
B0097225cellular_componentsperm midpiece
B0097720biological_processcalcineurin-mediated signaling
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098686cellular_componenthippocampal mossy fiber to CA3 synapse
B0098688cellular_componentparallel fiber to Purkinje cell synapse
B0098693biological_processregulation of synaptic vesicle cycle
B0098794cellular_componentpostsynapse
B0098901biological_processregulation of cardiac muscle cell action potential
B0098978cellular_componentglutamatergic synapse
B0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0099523cellular_componentpresynaptic cytosol
B0099524cellular_componentpostsynaptic cytosol
B0110062biological_processnegative regulation of angiotensin-activated signaling pathway
B0140056biological_processorganelle localization by membrane tethering
B0140238biological_processpresynaptic endocytosis
B1900242biological_processregulation of synaptic vesicle endocytosis
B1902494cellular_componentcatalytic complex
B1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
B1905205biological_processpositive regulation of connective tissue replacement
B1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
B2000300biological_processregulation of synaptic vesicle exocytosis
C0000082biological_processG1/S transition of mitotic cell cycle
C0000086biological_processG2/M transition of mitotic cell cycle
C0000922cellular_componentspindle pole
C0001569biological_processbranching involved in blood vessel morphogenesis
C0001837biological_processepithelial to mesenchymal transition
C0001975biological_processresponse to amphetamine
C0002027biological_processregulation of heart rate
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
C0005246molecular_functioncalcium channel regulator activity
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005876cellular_componentspindle microtubule
C0005886cellular_componentplasma membrane
C0005955cellular_componentcalcineurin complex
C0006470biological_processprotein dephosphorylation
C0006606biological_processprotein import into nucleus
C0006816biological_processcalcium ion transport
C0007507biological_processheart development
C0008076cellular_componentvoltage-gated potassium channel complex
C0008179molecular_functionadenylate cyclase binding
C0008544biological_processepidermis development
C0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
C0009898cellular_componentcytoplasmic side of plasma membrane
C0010613biological_processpositive regulation of cardiac muscle hypertrophy
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010856molecular_functionadenylate cyclase activator activity
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0014044biological_processSchwann cell development
C0014883biological_processtransition between fast and slow fiber
C0014898biological_processcardiac muscle hypertrophy in response to stress
C0016018molecular_functioncyclosporin A binding
C0016240biological_processautophagosome membrane docking
C0016311biological_processdephosphorylation
C0016787molecular_functionhydrolase activity
C0017018molecular_functionmyosin phosphatase activity
C0019722biological_processcalcium-mediated signaling
C0019855molecular_functioncalcium channel inhibitor activity
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0019902molecular_functionphosphatase binding
C0019904molecular_functionprotein domain specific binding
C0022011biological_processmyelination in peripheral nervous system
C0023057biological_processnegative regulation of signaling
C0030017cellular_componentsarcomere
C0030018cellular_componentZ disc
C0030216biological_processkeratinocyte differentiation
C0030235molecular_functionnitric-oxide synthase regulator activity
C0030335biological_processpositive regulation of cell migration
C0030426cellular_componentgrowth cone
C0030672cellular_componentsynaptic vesicle membrane
C0031432molecular_functiontitin binding
C0031514cellular_componentmotile cilium
C0031800molecular_functiontype 3 metabotropic glutamate receptor binding
C0031966cellular_componentmitochondrial membrane
C0032465biological_processregulation of cytokinesis
C0032991cellular_componentprotein-containing complex
C0033173biological_processcalcineurin-NFAT signaling cascade
C0033192molecular_functioncalmodulin-dependent protein phosphatase activity
C0033555biological_processmulticellular organismal response to stress
C0034504biological_processprotein localization to nucleus
C0034704cellular_componentcalcium channel complex
C0035307biological_processpositive regulation of protein dephosphorylation
C0035458biological_processcellular response to interferon-beta
C0036057cellular_componentslit diaphragm
C0042104biological_processpositive regulation of activated T cell proliferation
C0042383cellular_componentsarcolemma
C0042995cellular_componentcell projection
C0043197cellular_componentdendritic spine
C0043209cellular_componentmyelin sheath
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0043548molecular_functionphosphatidylinositol 3-kinase binding
C0044305cellular_componentcalyx of Held
C0044325molecular_functiontransmembrane transporter binding
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045669biological_processpositive regulation of osteoblast differentiation
C0045672biological_processpositive regulation of osteoclast differentiation
C0045785biological_processpositive regulation of cell adhesion
C0045807biological_processpositive regulation of endocytosis
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0045955biological_processnegative regulation of calcium ion-dependent exocytosis
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046676biological_processnegative regulation of insulin secretion
C0046872molecular_functionmetal ion binding
C0046878biological_processpositive regulation of saliva secretion
C0046983molecular_functionprotein dimerization activity
C0048306molecular_functioncalcium-dependent protein binding
C0048741biological_processskeletal muscle fiber development
C0048813biological_processdendrite morphogenesis
C0050774biological_processnegative regulation of dendrite morphogenesis
C0050804biological_processmodulation of chemical synaptic transmission
C0050998molecular_functionnitric-oxide synthase binding
C0051117molecular_functionATPase binding
C0051592biological_processresponse to calcium ion
C0055117biological_processregulation of cardiac muscle contraction
C0060079biological_processexcitatory postsynaptic potential
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0060487biological_processlung epithelial cell differentiation
C0061006biological_processregulation of cell proliferation involved in kidney morphogenesis
C0071333biological_processcellular response to glucose stimulus
C0071346biological_processcellular response to type II interferon
C0072542molecular_functionprotein phosphatase activator activity
C0090150biological_processestablishment of protein localization to membrane
C0090151biological_processestablishment of protein localization to mitochondrial membrane
C0090193biological_processpositive regulation of glomerulus development
C0097205biological_processrenal filtration
C0097225cellular_componentsperm midpiece
C0097720biological_processcalcineurin-mediated signaling
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098686cellular_componenthippocampal mossy fiber to CA3 synapse
C0098688cellular_componentparallel fiber to Purkinje cell synapse
C0098693biological_processregulation of synaptic vesicle cycle
C0098794cellular_componentpostsynapse
C0098901biological_processregulation of cardiac muscle cell action potential
C0098978cellular_componentglutamatergic synapse
C0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
C0099170biological_processpostsynaptic modulation of chemical synaptic transmission
C0099523cellular_componentpresynaptic cytosol
C0099524cellular_componentpostsynaptic cytosol
C0110062biological_processnegative regulation of angiotensin-activated signaling pathway
C0140056biological_processorganelle localization by membrane tethering
C0140238biological_processpresynaptic endocytosis
C1900242biological_processregulation of synaptic vesicle endocytosis
C1902494cellular_componentcatalytic complex
C1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
C1905205biological_processpositive regulation of connective tissue replacement
C1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
C2000300biological_processregulation of synaptic vesicle exocytosis
D0000082biological_processG1/S transition of mitotic cell cycle
D0000086biological_processG2/M transition of mitotic cell cycle
D0000922cellular_componentspindle pole
D0001569biological_processbranching involved in blood vessel morphogenesis
D0001837biological_processepithelial to mesenchymal transition
D0001975biological_processresponse to amphetamine
D0002027biological_processregulation of heart rate
D0004721molecular_functionphosphoprotein phosphatase activity
D0004722molecular_functionprotein serine/threonine phosphatase activity
D0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
D0005246molecular_functioncalcium channel regulator activity
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005876cellular_componentspindle microtubule
D0005886cellular_componentplasma membrane
D0005955cellular_componentcalcineurin complex
D0006470biological_processprotein dephosphorylation
D0006606biological_processprotein import into nucleus
D0006816biological_processcalcium ion transport
D0007507biological_processheart development
D0008076cellular_componentvoltage-gated potassium channel complex
D0008179molecular_functionadenylate cyclase binding
D0008544biological_processepidermis development
D0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
D0009898cellular_componentcytoplasmic side of plasma membrane
D0010613biological_processpositive regulation of cardiac muscle hypertrophy
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010856molecular_functionadenylate cyclase activator activity
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0014044biological_processSchwann cell development
D0014883biological_processtransition between fast and slow fiber
D0014898biological_processcardiac muscle hypertrophy in response to stress
D0016018molecular_functioncyclosporin A binding
D0016240biological_processautophagosome membrane docking
D0016311biological_processdephosphorylation
D0016787molecular_functionhydrolase activity
D0017018molecular_functionmyosin phosphatase activity
D0019722biological_processcalcium-mediated signaling
D0019855molecular_functioncalcium channel inhibitor activity
D0019899molecular_functionenzyme binding
D0019901molecular_functionprotein kinase binding
D0019902molecular_functionphosphatase binding
D0019904molecular_functionprotein domain specific binding
D0022011biological_processmyelination in peripheral nervous system
D0023057biological_processnegative regulation of signaling
D0030017cellular_componentsarcomere
D0030018cellular_componentZ disc
D0030216biological_processkeratinocyte differentiation
D0030235molecular_functionnitric-oxide synthase regulator activity
D0030335biological_processpositive regulation of cell migration
D0030426cellular_componentgrowth cone
D0030672cellular_componentsynaptic vesicle membrane
D0031432molecular_functiontitin binding
D0031514cellular_componentmotile cilium
D0031800molecular_functiontype 3 metabotropic glutamate receptor binding
D0031966cellular_componentmitochondrial membrane
D0032465biological_processregulation of cytokinesis
D0032991cellular_componentprotein-containing complex
D0033173biological_processcalcineurin-NFAT signaling cascade
D0033192molecular_functioncalmodulin-dependent protein phosphatase activity
D0033555biological_processmulticellular organismal response to stress
D0034504biological_processprotein localization to nucleus
D0034704cellular_componentcalcium channel complex
D0035307biological_processpositive regulation of protein dephosphorylation
D0035458biological_processcellular response to interferon-beta
D0036057cellular_componentslit diaphragm
D0042104biological_processpositive regulation of activated T cell proliferation
D0042383cellular_componentsarcolemma
D0042995cellular_componentcell projection
D0043197cellular_componentdendritic spine
D0043209cellular_componentmyelin sheath
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0043548molecular_functionphosphatidylinositol 3-kinase binding
D0044305cellular_componentcalyx of Held
D0044325molecular_functiontransmembrane transporter binding
D0044877molecular_functionprotein-containing complex binding
D0045202cellular_componentsynapse
D0045669biological_processpositive regulation of osteoblast differentiation
D0045672biological_processpositive regulation of osteoclast differentiation
D0045785biological_processpositive regulation of cell adhesion
D0045807biological_processpositive regulation of endocytosis
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0045955biological_processnegative regulation of calcium ion-dependent exocytosis
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046676biological_processnegative regulation of insulin secretion
D0046872molecular_functionmetal ion binding
D0046878biological_processpositive regulation of saliva secretion
D0046983molecular_functionprotein dimerization activity
D0048306molecular_functioncalcium-dependent protein binding
D0048741biological_processskeletal muscle fiber development
D0048813biological_processdendrite morphogenesis
D0050774biological_processnegative regulation of dendrite morphogenesis
D0050804biological_processmodulation of chemical synaptic transmission
D0050998molecular_functionnitric-oxide synthase binding
D0051117molecular_functionATPase binding
D0051592biological_processresponse to calcium ion
D0055117biological_processregulation of cardiac muscle contraction
D0060079biological_processexcitatory postsynaptic potential
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0060487biological_processlung epithelial cell differentiation
D0061006biological_processregulation of cell proliferation involved in kidney morphogenesis
D0071333biological_processcellular response to glucose stimulus
D0071346biological_processcellular response to type II interferon
D0072542molecular_functionprotein phosphatase activator activity
D0090150biological_processestablishment of protein localization to membrane
D0090151biological_processestablishment of protein localization to mitochondrial membrane
D0090193biological_processpositive regulation of glomerulus development
D0097205biological_processrenal filtration
D0097225cellular_componentsperm midpiece
D0097720biological_processcalcineurin-mediated signaling
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098686cellular_componenthippocampal mossy fiber to CA3 synapse
D0098688cellular_componentparallel fiber to Purkinje cell synapse
D0098693biological_processregulation of synaptic vesicle cycle
D0098794cellular_componentpostsynapse
D0098901biological_processregulation of cardiac muscle cell action potential
D0098978cellular_componentglutamatergic synapse
D0099149biological_processregulation of postsynaptic neurotransmitter receptor internalization
D0099170biological_processpostsynaptic modulation of chemical synaptic transmission
D0099523cellular_componentpresynaptic cytosol
D0099524cellular_componentpostsynaptic cytosol
D0110062biological_processnegative regulation of angiotensin-activated signaling pathway
D0140056biological_processorganelle localization by membrane tethering
D0140238biological_processpresynaptic endocytosis
D1900242biological_processregulation of synaptic vesicle endocytosis
D1902494cellular_componentcatalytic complex
D1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
D1905205biological_processpositive regulation of connective tissue replacement
D1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
D2000300biological_processregulation of synaptic vesicle exocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 901
ChainResidue
AASP188
AASP190
ASER192
ASER194
AGLU199

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 902
ChainResidue
AGLU231
AASP220
AASP222
AASN224
AGLU226

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 903
ChainResidue
AASP257
AASP259
AASP261
ATYR263
AGLU268
AHOH1018

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 904
ChainResidue
AASP298
AASP300
AASP302
AARG304
AGLU309

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 901
ChainResidue
BASP188
BASP190
BSER192
BSER194
BGLU199

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 902
ChainResidue
BASP220
BASP222
BASN224
BGLU226
BGLU231

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 903
ChainResidue
BASP257
BASP259
BASP261
BTYR263
BGLU268

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 904
ChainResidue
BASP298
BASP300
BASP302
BARG304
BGLU309

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 901
ChainResidue
CASP188
CASP190
CSER192
CSER194
CGLU199

site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 902
ChainResidue
CASP220
CASP222
CASN224
CGLU226
CGLU231

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 903
ChainResidue
CASP257
CASP259
CASP261
CTYR263
CGLU268

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 904
ChainResidue
CASP298
CASP300
CASP302
CARG304
CGLU309

site_idBC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA D 901
ChainResidue
DASP188
DASP190
DSER192
DSER194
DGLU199

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA D 902
ChainResidue
DASP220
DASP222
DASN224
DGLU226
DGLU231

site_idBC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 903
ChainResidue
DASP257
DASP259
DASP261
DTYR263
DGLU268
DHOH1007

site_idBC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA D 904
ChainResidue
DASP298
DASP300
DASP302
DARG304
DGLU309

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
AASP21-LEU33
AASP57-PHE69
AASP94-LEU106
AASP130-PHE142
AASP188-PHE200
AASP220-PHE232
AASP257-LEU269
AASP298-PHE310

site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
ALEU480-GLU485

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1G4Y, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3B32, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3IFK, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4G27, ECO:0007744|PDB:4G28, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4J9Y, ECO:0007744|PDB:4J9Z, ECO:0007744|PDB:4QNH
ChainResidueDetails
AASP21
BGLU32
CASP21
CASP23
CASP25
CTHR27
CGLU32
DASP21
DASP23
DASP25
DTHR27
AASP23
DGLU32
AASP25
ATHR27
AGLU32
BASP21
BASP23
BASP25
BTHR27

site_idSWS_FT_FI2
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1G4Y, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3B32, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3EK4, ECO:0007744|PDB:3EK7, ECO:0007744|PDB:3EK8, ECO:0007744|PDB:3EKH, ECO:0007744|PDB:3EVR, ECO:0007744|PDB:3EVU, ECO:0007744|PDB:3IFK, ECO:0007744|PDB:3SG2, ECO:0007744|PDB:3SG3, ECO:0007744|PDB:3SG4, ECO:0007744|PDB:3SG5, ECO:0007744|PDB:3SG6, ECO:0007744|PDB:3SG7, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:3WLC, ECO:0007744|PDB:3WLD, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4G27, ECO:0007744|PDB:4G28, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4J9Y, ECO:0007744|PDB:4J9Z, ECO:0007744|PDB:4QNH
ChainResidueDetails
AASP57
BGLU68
CASP57
CASP59
CASN61
CTHR63
CGLU68
DASP57
DASP59
DASN61
DTHR63
AASP59
DGLU68
AASN61
ATHR63
AGLU68
BASP57
BASP59
BASN61
BTHR63

site_idSWS_FT_FI3
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3EK4, ECO:0007744|PDB:3EK7, ECO:0007744|PDB:3EK8, ECO:0007744|PDB:3EKH, ECO:0007744|PDB:3EVR, ECO:0007744|PDB:3EVU, ECO:0007744|PDB:3SG2, ECO:0007744|PDB:3SG3, ECO:0007744|PDB:3SG4, ECO:0007744|PDB:3SG5, ECO:0007744|PDB:3SG6, ECO:0007744|PDB:3SG7, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:3WLC, ECO:0007744|PDB:3WLD, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4RJD
ChainResidueDetails
AASP94
BGLU105
CASP94
CASP96
CASN98
CTYR100
CGLU105
DASP94
DASP96
DASN98
DTYR100
AASP96
DGLU105
AASN98
ATYR100
AGLU105
BASP94
BASP96
BASN98
BTYR100

site_idSWS_FT_FI4
Number of Residues20
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:23109337, ECO:0000269|PubMed:3145979, ECO:0007744|PDB:1NIW, ECO:0007744|PDB:2HQW, ECO:0007744|PDB:2YGG, ECO:0007744|PDB:3BXK, ECO:0007744|PDB:3BXL, ECO:0007744|PDB:3CLN, ECO:0007744|PDB:3EK7, ECO:0007744|PDB:3EK8, ECO:0007744|PDB:3EKH, ECO:0007744|PDB:3EVR, ECO:0007744|PDB:3EVU, ECO:0007744|PDB:3SG2, ECO:0007744|PDB:3SG3, ECO:0007744|PDB:3SG4, ECO:0007744|PDB:3SG5, ECO:0007744|PDB:3SG7, ECO:0007744|PDB:3SJQ, ECO:0007744|PDB:3WLC, ECO:0007744|PDB:3WLD, ECO:0007744|PDB:4EHQ, ECO:0007744|PDB:4I2Y, ECO:0007744|PDB:4RJD
ChainResidueDetails
AASP130
BGLU141
CASP130
CASP132
CASP134
CGLN136
CGLU141
DASP130
DASP132
DASP134
DGLN136
AASP132
DGLU141
AASP134
AGLN136
AGLU141
BASP130
BASP132
BASP134
BGLN136

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000269|PubMed:201628, ECO:0000269|Ref.8
ChainResidueDetails
AALA2
BALA2
CALA2
DALA2

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
ALYS22
BLYS22
CLYS22
DLYS22

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: Phosphothreonine; by CaMK4 => ECO:0000269|PubMed:12392717
ChainResidueDetails
ATHR45
BTHR45
CTHR45
DTHR45

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
ASER82
BSER82
CSER82
DSER82

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
ALYS95
BLYS95
CLYS95
DLYS95

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ATYR100
BTYR100
CTYR100
DTYR100

site_idSWS_FT_FI11
Number of Residues8
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903
ChainResidueDetails
ASER102
BSER102
CSER102
DSER102
AILE802
BILE802
CILE802
DILE802

site_idSWS_FT_FI12
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
ATHR111
BTHR111
CTHR111
DTHR111

site_idSWS_FT_FI13
Number of Residues4
DetailsMOD_RES: N6-methyllysine; alternate => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
ALYS116
BLYS116
CLYS116
DLYS116

site_idSWS_FT_FI14
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P0DP23
ChainResidueDetails
ATYR139
BTYR139
CTYR139
DTYR139

site_idSWS_FT_FI15
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P62157
ChainResidueDetails
ALYS22
BLYS22
CLYS22
DLYS22

site_idSWS_FT_FI16
Number of Residues80
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448, ECO:0000269|PubMed:24018048, ECO:0007744|PDB:4IL1
ChainResidueDetails
AASP188
AGLU231
AASP257
AASP259
AASP261
ATYR263
AGLU268
AASP298
AASP300
AASP302
AARG304
AASP190
AGLU309
BASP188
BASP190
BSER192
BSER194
BGLU199
BASP220
BASP222
BASN224
BGLU226
ASER192
BGLU231
BASP257
BASP259
BASP261
BTYR263
BGLU268
BASP298
BASP300
BASP302
BARG304
ASER194
BGLU309
CASP188
CASP190
CSER192
CSER194
CGLU199
CASP220
CASP222
CASN224
CGLU226
AGLU199
CGLU231
CASP257
CASP259
CASP261
CTYR263
CGLU268
CASP298
CASP300
CASP302
CARG304
AASP220
CGLU309
DASP188
DASP190
DSER192
DSER194
DGLU199
DASP220
DASP222
DASN224
DGLU226
AASP222
DGLU231
DASP257
DASP259
DASP261
DTYR263
DGLU268
DASP298
DASP300
DASP302
DARG304
AASN224
DGLU309
AGLU226

site_idSWS_FT_FI17
Number of Residues8
DetailsSITE: Interaction with PxVP motif in substrates of the catalytic subunit => ECO:0000250|UniProtKB:P63098
ChainResidueDetails
AMET275
AASN279
BMET275
BASN279
CMET275
CASN279
DMET275
DASN279

site_idSWS_FT_FI18
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q63810
ChainResidueDetails
ATYR263
BTYR263
CTYR263
DTYR263

site_idSWS_FT_FI19
Number of Residues4
DetailsLIPID: N-myristoyl glycine => ECO:0000269|Ref.4
ChainResidueDetails
AGLY159
BGLY159
CGLY159
DGLY159

site_idSWS_FT_FI20
Number of Residues4
DetailsACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q08209
ChainResidueDetails
AHIS484
BHIS484
CHIS484
DHIS484

site_idSWS_FT_FI21
Number of Residues24
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q08209
ChainResidueDetails
AASP423
BASN483
BHIS532
BHIS614
CASP423
CHIS425
CASP451
CASN483
CHIS532
CHIS614
DASP423
AHIS425
DHIS425
DASP451
DASN483
DHIS532
DHIS614
AASP451
AASN483
AHIS532
AHIS614
BASP423
BHIS425
BASP451

site_idSWS_FT_FI22
Number of Residues4
DetailsSITE: Interaction with PxVP motif in substrate => ECO:0000250|UniProtKB:Q08209
ChainResidueDetails
ATRP685
BTRP685
CTRP685
DTRP685

site_idSWS_FT_FI23
Number of Residues4
DetailsMOD_RES: N-acetylserine => ECO:0000250|UniProtKB:Q08209
ChainResidueDetails
ASER335
BSER335
CSER335
DSER335

site_idSWS_FT_FI24
Number of Residues4
DetailsMOD_RES: 3'-nitrotyrosine => ECO:0000250|UniProtKB:P63328
ChainResidueDetails
ATYR557
BTYR557
CTYR557
DTYR557

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PDB entries from 2024-07-24

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