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4IL1

Crystal Structure of the Rat Calcineurin

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000086biological_processG2/M transition of mitotic cell cycle
A0000785cellular_componentchromatin
A0000922cellular_componentspindle pole
A0001975biological_processresponse to amphetamine
A0002027biological_processregulation of heart rate
A0004721molecular_functionphosphoprotein phosphatase activity
A0004722molecular_functionprotein serine/threonine phosphatase activity
A0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
A0005246molecular_functioncalcium channel regulator activity
A0005509molecular_functioncalcium ion binding
A0005513biological_processdetection of calcium ion
A0005515molecular_functionprotein binding
A0005516molecular_functioncalmodulin binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005876cellular_componentspindle microtubule
A0005886cellular_componentplasma membrane
A0005955cellular_componentcalcineurin complex
A0006470biological_processprotein dephosphorylation
A0006606biological_processprotein import into nucleus
A0006816biological_processcalcium ion transport
A0007259biological_processcell surface receptor signaling pathway via JAK-STAT
A0008076cellular_componentvoltage-gated potassium channel complex
A0008179molecular_functionadenylate cyclase binding
A0008544biological_processepidermis development
A0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010613biological_processpositive regulation of cardiac muscle hypertrophy
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0010856molecular_functionadenylate cyclase activator activity
A0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A0014883biological_processtransition between fast and slow fiber
A0014898biological_processcardiac muscle hypertrophy in response to stress
A0016020cellular_componentmembrane
A0016240biological_processautophagosome membrane docking
A0016787molecular_functionhydrolase activity
A0019722biological_processcalcium-mediated signaling
A0019855molecular_functioncalcium channel inhibitor activity
A0019899molecular_functionenzyme binding
A0019901molecular_functionprotein kinase binding
A0019902molecular_functionphosphatase binding
A0019904molecular_functionprotein domain specific binding
A0023057biological_processnegative regulation of signaling
A0030017cellular_componentsarcomere
A0030018cellular_componentZ disc
A0030216biological_processkeratinocyte differentiation
A0030235molecular_functionnitric-oxide synthase regulator activity
A0030335biological_processpositive regulation of cell migration
A0030426cellular_componentgrowth cone
A0030672cellular_componentsynaptic vesicle membrane
A0031432molecular_functiontitin binding
A0031514cellular_componentmotile cilium
A0031800molecular_functiontype 3 metabotropic glutamate receptor binding
A0031966cellular_componentmitochondrial membrane
A0031982cellular_componentvesicle
A0032465biological_processregulation of cytokinesis
A0032991cellular_componentprotein-containing complex
A0033173biological_processcalcineurin-NFAT signaling cascade
A0033192molecular_functioncalmodulin-dependent protein phosphatase activity
A0033555biological_processmulticellular organismal response to stress
A0034704cellular_componentcalcium channel complex
A0035458biological_processcellular response to interferon-beta
A0036057cellular_componentslit diaphragm
A0042104biological_processpositive regulation of activated T cell proliferation
A0042383cellular_componentsarcolemma
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043197cellular_componentdendritic spine
A0043209cellular_componentmyelin sheath
A0043539molecular_functionprotein serine/threonine kinase activator activity
A0043548molecular_functionphosphatidylinositol 3-kinase binding
A0044305cellular_componentcalyx of Held
A0044325molecular_functiontransmembrane transporter binding
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045669biological_processpositive regulation of osteoblast differentiation
A0045672biological_processpositive regulation of osteoclast differentiation
A0045785biological_processpositive regulation of cell adhesion
A0045807biological_processpositive regulation of endocytosis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0045955biological_processnegative regulation of calcium ion-dependent exocytosis
A0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
A0046676biological_processnegative regulation of insulin secretion
A0046872molecular_functionmetal ion binding
A0046878biological_processpositive regulation of saliva secretion
A0046983molecular_functionprotein dimerization activity
A0048306molecular_functioncalcium-dependent protein binding
A0048741biological_processskeletal muscle fiber development
A0050774biological_processnegative regulation of dendrite morphogenesis
A0050796biological_processregulation of insulin secretion
A0050804biological_processmodulation of chemical synaptic transmission
A0050848biological_processregulation of calcium-mediated signaling
A0050998molecular_functionnitric-oxide synthase binding
A0051117molecular_functionATPase binding
A0051412biological_processresponse to corticosterone
A0051592biological_processresponse to calcium ion
A0055117biological_processregulation of cardiac muscle contraction
A0060079biological_processexcitatory postsynaptic potential
A0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
A0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
A0061006biological_processregulation of cell proliferation involved in kidney morphogenesis
A0070294biological_processrenal sodium ion absorption
A0071333biological_processcellular response to glucose stimulus
A0071346biological_processcellular response to type II interferon
A0072542molecular_functionprotein phosphatase activator activity
A0090150biological_processestablishment of protein localization to membrane
A0090151biological_processestablishment of protein localization to mitochondrial membrane
A0090193biological_processpositive regulation of glomerulus development
A0097205biological_processrenal filtration
A0097225cellular_componentsperm midpiece
A0097720biological_processcalcineurin-mediated signaling
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098901biological_processregulation of cardiac muscle cell action potential
A0098978cellular_componentglutamatergic synapse
A0099170biological_processpostsynaptic modulation of chemical synaptic transmission
A0099523cellular_componentpresynaptic cytosol
A0099524cellular_componentpostsynaptic cytosol
A0110062biological_processnegative regulation of angiotensin-activated signaling pathway
A0110063biological_processpositive regulation of angiotensin-activated signaling pathway
A0140056biological_processorganelle localization by membrane tethering
A0140238biological_processpresynaptic endocytosis
A0141110molecular_functiontransporter inhibitor activity
A1900242biological_processregulation of synaptic vesicle endocytosis
A1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
A1902494cellular_componentcatalytic complex
A1903235biological_processpositive regulation of calcium ion-dependent exocytosis of neurotransmitter
A1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
A1905205biological_processpositive regulation of connective tissue replacement
A1905913biological_processnegative regulation of calcium ion export across plasma membrane
A1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
A2000300biological_processregulation of synaptic vesicle exocytosis
B0000082biological_processG1/S transition of mitotic cell cycle
B0000086biological_processG2/M transition of mitotic cell cycle
B0000785cellular_componentchromatin
B0000922cellular_componentspindle pole
B0001975biological_processresponse to amphetamine
B0002027biological_processregulation of heart rate
B0004721molecular_functionphosphoprotein phosphatase activity
B0004722molecular_functionprotein serine/threonine phosphatase activity
B0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
B0005246molecular_functioncalcium channel regulator activity
B0005509molecular_functioncalcium ion binding
B0005513biological_processdetection of calcium ion
B0005515molecular_functionprotein binding
B0005516molecular_functioncalmodulin binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005876cellular_componentspindle microtubule
B0005886cellular_componentplasma membrane
B0005955cellular_componentcalcineurin complex
B0006470biological_processprotein dephosphorylation
B0006606biological_processprotein import into nucleus
B0006816biological_processcalcium ion transport
B0007259biological_processcell surface receptor signaling pathway via JAK-STAT
B0008076cellular_componentvoltage-gated potassium channel complex
B0008179molecular_functionadenylate cyclase binding
B0008544biological_processepidermis development
B0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
B0009898cellular_componentcytoplasmic side of plasma membrane
B0010613biological_processpositive regulation of cardiac muscle hypertrophy
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0010856molecular_functionadenylate cyclase activator activity
B0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
B0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
B0014883biological_processtransition between fast and slow fiber
B0014898biological_processcardiac muscle hypertrophy in response to stress
B0016020cellular_componentmembrane
B0016240biological_processautophagosome membrane docking
B0016787molecular_functionhydrolase activity
B0019722biological_processcalcium-mediated signaling
B0019855molecular_functioncalcium channel inhibitor activity
B0019899molecular_functionenzyme binding
B0019901molecular_functionprotein kinase binding
B0019902molecular_functionphosphatase binding
B0019904molecular_functionprotein domain specific binding
B0023057biological_processnegative regulation of signaling
B0030017cellular_componentsarcomere
B0030018cellular_componentZ disc
B0030216biological_processkeratinocyte differentiation
B0030235molecular_functionnitric-oxide synthase regulator activity
B0030335biological_processpositive regulation of cell migration
B0030426cellular_componentgrowth cone
B0030672cellular_componentsynaptic vesicle membrane
B0031432molecular_functiontitin binding
B0031514cellular_componentmotile cilium
B0031800molecular_functiontype 3 metabotropic glutamate receptor binding
B0031966cellular_componentmitochondrial membrane
B0031982cellular_componentvesicle
B0032465biological_processregulation of cytokinesis
B0032991cellular_componentprotein-containing complex
B0033173biological_processcalcineurin-NFAT signaling cascade
B0033192molecular_functioncalmodulin-dependent protein phosphatase activity
B0033555biological_processmulticellular organismal response to stress
B0034704cellular_componentcalcium channel complex
B0035458biological_processcellular response to interferon-beta
B0036057cellular_componentslit diaphragm
B0042104biological_processpositive regulation of activated T cell proliferation
B0042383cellular_componentsarcolemma
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043197cellular_componentdendritic spine
B0043209cellular_componentmyelin sheath
B0043539molecular_functionprotein serine/threonine kinase activator activity
B0043548molecular_functionphosphatidylinositol 3-kinase binding
B0044305cellular_componentcalyx of Held
B0044325molecular_functiontransmembrane transporter binding
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0045669biological_processpositive regulation of osteoblast differentiation
B0045672biological_processpositive regulation of osteoclast differentiation
B0045785biological_processpositive regulation of cell adhesion
B0045807biological_processpositive regulation of endocytosis
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0045955biological_processnegative regulation of calcium ion-dependent exocytosis
B0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
B0046676biological_processnegative regulation of insulin secretion
B0046872molecular_functionmetal ion binding
B0046878biological_processpositive regulation of saliva secretion
B0046983molecular_functionprotein dimerization activity
B0048306molecular_functioncalcium-dependent protein binding
B0048741biological_processskeletal muscle fiber development
B0050774biological_processnegative regulation of dendrite morphogenesis
B0050796biological_processregulation of insulin secretion
B0050804biological_processmodulation of chemical synaptic transmission
B0050848biological_processregulation of calcium-mediated signaling
B0050998molecular_functionnitric-oxide synthase binding
B0051117molecular_functionATPase binding
B0051412biological_processresponse to corticosterone
B0051592biological_processresponse to calcium ion
B0055117biological_processregulation of cardiac muscle contraction
B0060079biological_processexcitatory postsynaptic potential
B0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
B0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
B0061006biological_processregulation of cell proliferation involved in kidney morphogenesis
B0070294biological_processrenal sodium ion absorption
B0071333biological_processcellular response to glucose stimulus
B0071346biological_processcellular response to type II interferon
B0072542molecular_functionprotein phosphatase activator activity
B0090150biological_processestablishment of protein localization to membrane
B0090151biological_processestablishment of protein localization to mitochondrial membrane
B0090193biological_processpositive regulation of glomerulus development
B0097205biological_processrenal filtration
B0097225cellular_componentsperm midpiece
B0097720biological_processcalcineurin-mediated signaling
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098901biological_processregulation of cardiac muscle cell action potential
B0098978cellular_componentglutamatergic synapse
B0099170biological_processpostsynaptic modulation of chemical synaptic transmission
B0099523cellular_componentpresynaptic cytosol
B0099524cellular_componentpostsynaptic cytosol
B0110062biological_processnegative regulation of angiotensin-activated signaling pathway
B0110063biological_processpositive regulation of angiotensin-activated signaling pathway
B0140056biological_processorganelle localization by membrane tethering
B0140238biological_processpresynaptic endocytosis
B0141110molecular_functiontransporter inhibitor activity
B1900242biological_processregulation of synaptic vesicle endocytosis
B1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
B1902494cellular_componentcatalytic complex
B1903235biological_processpositive regulation of calcium ion-dependent exocytosis of neurotransmitter
B1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
B1905205biological_processpositive regulation of connective tissue replacement
B1905913biological_processnegative regulation of calcium ion export across plasma membrane
B1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
B2000300biological_processregulation of synaptic vesicle exocytosis
C0000082biological_processG1/S transition of mitotic cell cycle
C0000086biological_processG2/M transition of mitotic cell cycle
C0000785cellular_componentchromatin
C0000922cellular_componentspindle pole
C0001975biological_processresponse to amphetamine
C0002027biological_processregulation of heart rate
C0004721molecular_functionphosphoprotein phosphatase activity
C0004722molecular_functionprotein serine/threonine phosphatase activity
C0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
C0005246molecular_functioncalcium channel regulator activity
C0005509molecular_functioncalcium ion binding
C0005513biological_processdetection of calcium ion
C0005515molecular_functionprotein binding
C0005516molecular_functioncalmodulin binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005813cellular_componentcentrosome
C0005819cellular_componentspindle
C0005829cellular_componentcytosol
C0005876cellular_componentspindle microtubule
C0005886cellular_componentplasma membrane
C0005955cellular_componentcalcineurin complex
C0006470biological_processprotein dephosphorylation
C0006606biological_processprotein import into nucleus
C0006816biological_processcalcium ion transport
C0007259biological_processcell surface receptor signaling pathway via JAK-STAT
C0008076cellular_componentvoltage-gated potassium channel complex
C0008179molecular_functionadenylate cyclase binding
C0008544biological_processepidermis development
C0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
C0009898cellular_componentcytoplasmic side of plasma membrane
C0010613biological_processpositive regulation of cardiac muscle hypertrophy
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0010856molecular_functionadenylate cyclase activator activity
C0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C0014883biological_processtransition between fast and slow fiber
C0014898biological_processcardiac muscle hypertrophy in response to stress
C0016020cellular_componentmembrane
C0016240biological_processautophagosome membrane docking
C0016787molecular_functionhydrolase activity
C0019722biological_processcalcium-mediated signaling
C0019855molecular_functioncalcium channel inhibitor activity
C0019899molecular_functionenzyme binding
C0019901molecular_functionprotein kinase binding
C0019902molecular_functionphosphatase binding
C0019904molecular_functionprotein domain specific binding
C0023057biological_processnegative regulation of signaling
C0030017cellular_componentsarcomere
C0030018cellular_componentZ disc
C0030216biological_processkeratinocyte differentiation
C0030235molecular_functionnitric-oxide synthase regulator activity
C0030335biological_processpositive regulation of cell migration
C0030426cellular_componentgrowth cone
C0030672cellular_componentsynaptic vesicle membrane
C0031432molecular_functiontitin binding
C0031514cellular_componentmotile cilium
C0031800molecular_functiontype 3 metabotropic glutamate receptor binding
C0031966cellular_componentmitochondrial membrane
C0031982cellular_componentvesicle
C0032465biological_processregulation of cytokinesis
C0032991cellular_componentprotein-containing complex
C0033173biological_processcalcineurin-NFAT signaling cascade
C0033192molecular_functioncalmodulin-dependent protein phosphatase activity
C0033555biological_processmulticellular organismal response to stress
C0034704cellular_componentcalcium channel complex
C0035458biological_processcellular response to interferon-beta
C0036057cellular_componentslit diaphragm
C0042104biological_processpositive regulation of activated T cell proliferation
C0042383cellular_componentsarcolemma
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043197cellular_componentdendritic spine
C0043209cellular_componentmyelin sheath
C0043539molecular_functionprotein serine/threonine kinase activator activity
C0043548molecular_functionphosphatidylinositol 3-kinase binding
C0044305cellular_componentcalyx of Held
C0044325molecular_functiontransmembrane transporter binding
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045669biological_processpositive regulation of osteoblast differentiation
C0045672biological_processpositive regulation of osteoclast differentiation
C0045785biological_processpositive regulation of cell adhesion
C0045807biological_processpositive regulation of endocytosis
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0045955biological_processnegative regulation of calcium ion-dependent exocytosis
C0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
C0046676biological_processnegative regulation of insulin secretion
C0046872molecular_functionmetal ion binding
C0046878biological_processpositive regulation of saliva secretion
C0046983molecular_functionprotein dimerization activity
C0048306molecular_functioncalcium-dependent protein binding
C0048741biological_processskeletal muscle fiber development
C0050774biological_processnegative regulation of dendrite morphogenesis
C0050796biological_processregulation of insulin secretion
C0050804biological_processmodulation of chemical synaptic transmission
C0050848biological_processregulation of calcium-mediated signaling
C0050998molecular_functionnitric-oxide synthase binding
C0051117molecular_functionATPase binding
C0051412biological_processresponse to corticosterone
C0051592biological_processresponse to calcium ion
C0055117biological_processregulation of cardiac muscle contraction
C0060079biological_processexcitatory postsynaptic potential
C0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
C0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
C0061006biological_processregulation of cell proliferation involved in kidney morphogenesis
C0070294biological_processrenal sodium ion absorption
C0071333biological_processcellular response to glucose stimulus
C0071346biological_processcellular response to type II interferon
C0072542molecular_functionprotein phosphatase activator activity
C0090150biological_processestablishment of protein localization to membrane
C0090151biological_processestablishment of protein localization to mitochondrial membrane
C0090193biological_processpositive regulation of glomerulus development
C0097205biological_processrenal filtration
C0097225cellular_componentsperm midpiece
C0097720biological_processcalcineurin-mediated signaling
C0098685cellular_componentSchaffer collateral - CA1 synapse
C0098901biological_processregulation of cardiac muscle cell action potential
C0098978cellular_componentglutamatergic synapse
C0099170biological_processpostsynaptic modulation of chemical synaptic transmission
C0099523cellular_componentpresynaptic cytosol
C0099524cellular_componentpostsynaptic cytosol
C0110062biological_processnegative regulation of angiotensin-activated signaling pathway
C0110063biological_processpositive regulation of angiotensin-activated signaling pathway
C0140056biological_processorganelle localization by membrane tethering
C0140238biological_processpresynaptic endocytosis
C0141110molecular_functiontransporter inhibitor activity
C1900242biological_processregulation of synaptic vesicle endocytosis
C1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
C1902494cellular_componentcatalytic complex
C1903235biological_processpositive regulation of calcium ion-dependent exocytosis of neurotransmitter
C1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
C1905205biological_processpositive regulation of connective tissue replacement
C1905913biological_processnegative regulation of calcium ion export across plasma membrane
C1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
C2000300biological_processregulation of synaptic vesicle exocytosis
D0000082biological_processG1/S transition of mitotic cell cycle
D0000086biological_processG2/M transition of mitotic cell cycle
D0000785cellular_componentchromatin
D0000922cellular_componentspindle pole
D0001975biological_processresponse to amphetamine
D0002027biological_processregulation of heart rate
D0004721molecular_functionphosphoprotein phosphatase activity
D0004722molecular_functionprotein serine/threonine phosphatase activity
D0004723molecular_functioncalcium-dependent protein serine/threonine phosphatase activity
D0005246molecular_functioncalcium channel regulator activity
D0005509molecular_functioncalcium ion binding
D0005513biological_processdetection of calcium ion
D0005515molecular_functionprotein binding
D0005516molecular_functioncalmodulin binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005813cellular_componentcentrosome
D0005819cellular_componentspindle
D0005829cellular_componentcytosol
D0005876cellular_componentspindle microtubule
D0005886cellular_componentplasma membrane
D0005955cellular_componentcalcineurin complex
D0006470biological_processprotein dephosphorylation
D0006606biological_processprotein import into nucleus
D0006816biological_processcalcium ion transport
D0007259biological_processcell surface receptor signaling pathway via JAK-STAT
D0008076cellular_componentvoltage-gated potassium channel complex
D0008179molecular_functionadenylate cyclase binding
D0008544biological_processepidermis development
D0008597molecular_functioncalcium-dependent protein serine/threonine phosphatase regulator activity
D0009898cellular_componentcytoplasmic side of plasma membrane
D0010613biological_processpositive regulation of cardiac muscle hypertrophy
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0010856molecular_functionadenylate cyclase activator activity
D0010880biological_processregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
D0010881biological_processregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
D0014883biological_processtransition between fast and slow fiber
D0014898biological_processcardiac muscle hypertrophy in response to stress
D0016020cellular_componentmembrane
D0016240biological_processautophagosome membrane docking
D0016787molecular_functionhydrolase activity
D0019722biological_processcalcium-mediated signaling
D0019855molecular_functioncalcium channel inhibitor activity
D0019899molecular_functionenzyme binding
D0019901molecular_functionprotein kinase binding
D0019902molecular_functionphosphatase binding
D0019904molecular_functionprotein domain specific binding
D0023057biological_processnegative regulation of signaling
D0030017cellular_componentsarcomere
D0030018cellular_componentZ disc
D0030216biological_processkeratinocyte differentiation
D0030235molecular_functionnitric-oxide synthase regulator activity
D0030335biological_processpositive regulation of cell migration
D0030426cellular_componentgrowth cone
D0030672cellular_componentsynaptic vesicle membrane
D0031432molecular_functiontitin binding
D0031514cellular_componentmotile cilium
D0031800molecular_functiontype 3 metabotropic glutamate receptor binding
D0031966cellular_componentmitochondrial membrane
D0031982cellular_componentvesicle
D0032465biological_processregulation of cytokinesis
D0032991cellular_componentprotein-containing complex
D0033173biological_processcalcineurin-NFAT signaling cascade
D0033192molecular_functioncalmodulin-dependent protein phosphatase activity
D0033555biological_processmulticellular organismal response to stress
D0034704cellular_componentcalcium channel complex
D0035458biological_processcellular response to interferon-beta
D0036057cellular_componentslit diaphragm
D0042104biological_processpositive regulation of activated T cell proliferation
D0042383cellular_componentsarcolemma
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043197cellular_componentdendritic spine
D0043209cellular_componentmyelin sheath
D0043539molecular_functionprotein serine/threonine kinase activator activity
D0043548molecular_functionphosphatidylinositol 3-kinase binding
D0044305cellular_componentcalyx of Held
D0044325molecular_functiontransmembrane transporter binding
D0044877molecular_functionprotein-containing complex binding
D0045202cellular_componentsynapse
D0045669biological_processpositive regulation of osteoblast differentiation
D0045672biological_processpositive regulation of osteoclast differentiation
D0045785biological_processpositive regulation of cell adhesion
D0045807biological_processpositive regulation of endocytosis
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0045955biological_processnegative regulation of calcium ion-dependent exocytosis
D0046427biological_processpositive regulation of receptor signaling pathway via JAK-STAT
D0046676biological_processnegative regulation of insulin secretion
D0046872molecular_functionmetal ion binding
D0046878biological_processpositive regulation of saliva secretion
D0046983molecular_functionprotein dimerization activity
D0048306molecular_functioncalcium-dependent protein binding
D0048741biological_processskeletal muscle fiber development
D0050774biological_processnegative regulation of dendrite morphogenesis
D0050796biological_processregulation of insulin secretion
D0050804biological_processmodulation of chemical synaptic transmission
D0050848biological_processregulation of calcium-mediated signaling
D0050998molecular_functionnitric-oxide synthase binding
D0051117molecular_functionATPase binding
D0051412biological_processresponse to corticosterone
D0051592biological_processresponse to calcium ion
D0055117biological_processregulation of cardiac muscle contraction
D0060079biological_processexcitatory postsynaptic potential
D0060314biological_processregulation of ryanodine-sensitive calcium-release channel activity
D0060315biological_processnegative regulation of ryanodine-sensitive calcium-release channel activity
D0061006biological_processregulation of cell proliferation involved in kidney morphogenesis
D0070294biological_processrenal sodium ion absorption
D0071333biological_processcellular response to glucose stimulus
D0071346biological_processcellular response to type II interferon
D0072542molecular_functionprotein phosphatase activator activity
D0090150biological_processestablishment of protein localization to membrane
D0090151biological_processestablishment of protein localization to mitochondrial membrane
D0090193biological_processpositive regulation of glomerulus development
D0097205biological_processrenal filtration
D0097225cellular_componentsperm midpiece
D0097720biological_processcalcineurin-mediated signaling
D0098685cellular_componentSchaffer collateral - CA1 synapse
D0098901biological_processregulation of cardiac muscle cell action potential
D0098978cellular_componentglutamatergic synapse
D0099170biological_processpostsynaptic modulation of chemical synaptic transmission
D0099523cellular_componentpresynaptic cytosol
D0099524cellular_componentpostsynaptic cytosol
D0110062biological_processnegative regulation of angiotensin-activated signaling pathway
D0110063biological_processpositive regulation of angiotensin-activated signaling pathway
D0140056biological_processorganelle localization by membrane tethering
D0140238biological_processpresynaptic endocytosis
D0141110molecular_functiontransporter inhibitor activity
D1900242biological_processregulation of synaptic vesicle endocytosis
D1901844biological_processregulation of cell communication by electrical coupling involved in cardiac conduction
D1902494cellular_componentcatalytic complex
D1903235biological_processpositive regulation of calcium ion-dependent exocytosis of neurotransmitter
D1903244biological_processpositive regulation of cardiac muscle hypertrophy in response to stress
D1905205biological_processpositive regulation of connective tissue replacement
D1905913biological_processnegative regulation of calcium ion export across plasma membrane
D1990456biological_processmitochondrion-endoplasmic reticulum membrane tethering
D2000300biological_processregulation of synaptic vesicle exocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 901
ChainResidue
AASP188
AASP190
ASER192
ASER194
AGLU199

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 902
ChainResidue
AGLU231
AASP220
AASP222
AASN224
AGLU226

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 903
ChainResidue
AASP257
AASP259
AASP261
ATYR263
AGLU268
AHOH1018

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 904
ChainResidue
AASP298
AASP300
AASP302
AARG304
AGLU309

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 901
ChainResidue
BASP188
BASP190
BSER192
BSER194
BGLU199

site_idAC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 902
ChainResidue
BASP220
BASP222
BASN224
BGLU226
BGLU231

site_idAC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 903
ChainResidue
BASP257
BASP259
BASP261
BTYR263
BGLU268

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 904
ChainResidue
BASP298
BASP300
BASP302
BARG304
BGLU309

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 901
ChainResidue
CASP188
CASP190
CSER192
CSER194
CGLU199

site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 902
ChainResidue
CASP220
CASP222
CASN224
CGLU226
CGLU231

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 903
ChainResidue
CASP257
CASP259
CASP261
CTYR263
CGLU268

site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 904
ChainResidue
CASP298
CASP300
CASP302
CARG304
CGLU309

site_idBC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA D 901
ChainResidue
DASP188
DASP190
DSER192
DSER194
DGLU199

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA D 902
ChainResidue
DASP220
DASP222
DASN224
DGLU226
DGLU231

site_idBC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA D 903
ChainResidue
DASP257
DASP259
DASP261
DTYR263
DGLU268
DHOH1007

site_idBC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA D 904
ChainResidue
DASP298
DASP300
DASP302
DARG304
DGLU309

Functional Information from PROSITE/UniProt
site_idPS00018
Number of Residues13
DetailsEF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL
ChainResidueDetails
AASP21-LEU33
AASP57-PHE69
AASP94-LEU106
AASP130-PHE142
AASP188-PHE200
AASP220-PHE232
AASP257-LEU269
AASP298-PHE310

site_idPS00125
Number of Residues6
DetailsSER_THR_PHOSPHATASE Serine/threonine specific protein phosphatases signature. LRGNHE
ChainResidueDetails
ALEU480-GLU485

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues112
DetailsDomain: {"description":"EF-hand 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues140
DetailsDomain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues140
DetailsDomain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues20
DetailsRegion: {"description":"Calcineurin A binding","evidences":[{"source":"UniProtKB","id":"P63098","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues80
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24018048","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4IL1","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues8
DetailsSite: {"description":"Interaction with PxVP motif in substrates of the catalytic subunit","evidences":[{"source":"UniProtKB","id":"P63098","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q63810","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1136
DetailsRegion: {"description":"Catalytic","evidences":[{"evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues36
DetailsRegion: {"description":"Interaction with PxIxIF motif in substrate","evidences":[{"source":"UniProtKB","id":"Q08209","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues112
DetailsRegion: {"description":"Calcineurin B binding","evidences":[{"source":"UniProtKB","id":"Q08209","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues16
DetailsMotif: {"description":"SAPNY motif","evidences":[{"source":"UniProtKB","id":"Q08209","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues4
DetailsActive site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"Q08209","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues24
DetailsBinding site: {"evidences":[{"source":"UniProtKB","id":"Q08209","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues4
DetailsSite: {"description":"Interaction with PxVP motif in substrate","evidences":[{"source":"UniProtKB","id":"Q08209","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues4
DetailsModified residue: {"description":"3'-nitrotyrosine","evidences":[{"source":"UniProtKB","id":"P63328","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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