4IJX

Crystal structure of human Ap4A hydrolase E58A mutant complexed with DPO

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004081	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005759	cellular_component	mitochondrial matrix
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006167	biological_process	AMP biosynthetic process
A	0006754	biological_process	ATP biosynthetic process
A	0006915	biological_process	apoptotic process
A	0008796	molecular_function	bis(5'-nucleosyl)-tetraphosphatase activity
A	0008803	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
A	0016787	molecular_function	hydrolase activity
A	0034599	biological_process	cellular response to oxidative stress
B	0004081	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005759	cellular_component	mitochondrial matrix
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006167	biological_process	AMP biosynthetic process
B	0006754	biological_process	ATP biosynthetic process
B	0006915	biological_process	apoptotic process
B	0008796	molecular_function	bis(5'-nucleosyl)-tetraphosphatase activity
B	0008803	molecular_function	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
B	0016787	molecular_function	hydrolase activity
B	0034599	biological_process	cellular response to oxidative stress

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 201

Chain	Residue
A	ASP50
A	GLU53
A	GLN140
B	LYS77
B	TRP94

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE DPO A 202

Chain	Residue
A	LYS42
A	TYR82
A	LYS89

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 203

Chain	Residue
A	ALA23
A	ILE24
A	GLY118
A	LEU119
A	HIS139
A	HOH337
A	ASN22

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site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 B 201

Chain	Residue
A	ARG12
A	TRP116
A	HOH311
B	TYR114
B	TRP116
B	HOH304
B	HOH307
B	HOH312
B	HOH352

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 B 202

Chain	Residue
B	LYS42
B	TYR82
B	LYS89

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N-acetylalanine => ECO:0000269|Ref.5

Chain	Residue	Details
A	ALA2
B	ALA2

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