Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004839 | molecular_function | ubiquitin activating enzyme activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| A | 0006974 | biological_process | DNA damage response |
| A | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| A | 0016567 | biological_process | protein ubiquitination |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0036211 | biological_process | protein modification process |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0004839 | molecular_function | ubiquitin activating enzyme activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005634 | cellular_component | nucleus |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
| C | 0006974 | biological_process | DNA damage response |
| C | 0008641 | molecular_function | ubiquitin-like modifier activating enzyme activity |
| C | 0016567 | biological_process | protein ubiquitination |
| C | 0016874 | molecular_function | ligase activity |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0036211 | biological_process | protein modification process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1101 |
| Chain | Residue |
| A | ASP537 |
| A | ATP1103 |
| A | HOH1226 |
| A | HOH1263 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 1102 |
| Chain | Residue |
| A | ASP465 |
| A | GLU468 |
| A | ATP1103 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ATP A 1103 |
| Chain | Residue |
| A | ALA437 |
| A | ASP463 |
| A | MET464 |
| A | ASP465 |
| A | ARG474 |
| A | LYS487 |
| A | VAL513 |
| A | ALA535 |
| A | ASP537 |
| A | ASN538 |
| A | ALA541 |
| A | MG1101 |
| A | MG1102 |
| A | HOH1226 |
| A | HOH1246 |
| A | HOH1259 |
| A | HOH1263 |
| B | GLY76 |
| A | ARG22 |
| A | GLY436 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA A 1104 |
| Chain | Residue |
| A | ASP918 |
| A | HOH1202 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA A 1105 |
| Chain | Residue |
| A | GLU205 |
| A | HOH1230 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA A 1106 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA A 1107 |
| Chain | Residue |
| A | TYR920 |
| A | GLU938 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 1101 |
| Chain | Residue |
| C | ASP537 |
| C | ATP1103 |
| C | HOH1213 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG C 1102 |
| Chain | Residue |
| C | ASP465 |
| C | GLU468 |
| C | ATP1103 |
| site_id | BC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ATP C 1103 |
| Chain | Residue |
| C | ARG22 |
| C | GLY436 |
| C | ALA437 |
| C | ASP463 |
| C | MET464 |
| C | ASP465 |
| C | ASN471 |
| C | ARG474 |
| C | LYS487 |
| C | ARG512 |
| C | VAL513 |
| C | ALA535 |
| C | ASP537 |
| C | ASN538 |
| C | MG1101 |
| C | MG1102 |
| C | HOH1213 |
| D | GLY76 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 1104 |
| Chain | Residue |
| A | THR261 |
| C | ASP996 |
| C | GLY1000 |
| C | HOH1240 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA C 1105 |
| Chain | Residue |
| C | ASP918 |
| C | HOH1241 |
| C | HOH1242 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CA C 1106 |
| Chain | Residue |
| C | ASP611 |
| C | GLN619 |
| site_id | BC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA C 1107 |
| site_id | BC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA C 1108 |
| site_id | BC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CA C 1109 |
Functional Information from PROSITE/UniProt
| site_id | PS00299 |
| Number of Residues | 26 |
| Details | UBIQUITIN_1 Ubiquitin domain signature. KskIqDkegIPpdqQrLIFaGkqleD |
| Chain | Residue | Details |
| B | LYS27-ASP52 | |
| site_id | PS00865 |
| Number of Residues | 9 |
| Details | UBIQUITIN_ACTIVAT_2 Ubiquitin-activating enzyme active site. PICTLKnFP |
| Chain | Residue | Details |
| A | PRO591-PRO599 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
| Chain | Residue | Details |
| B | LYS6 | |
| B | LYS11 | |
| B | LYS27 | |
| B | LYS33 | |
| D | LYS6 | |
| D | LYS11 | |
| D | LYS27 | |
| D | LYS33 | |
| Chain | Residue | Details |
| A | ARG22 | |
| C | LYS487 | |
| C | VAL513 | |
| C | ASP537 | |
| B | GLY76 | |
| A | ASP463 | |
| D | GLY76 | |
| A | VAL513 | |
| A | ASP537 | |
| C | ARG22 | |
| C | ALA437 | |
| C | ASP463 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250 |
| Chain | Residue | Details |
| B | LYS29 | |
| B | LYS48 | |
| B | LYS63 | |
| D | LYS29 | |
| D | LYS48 | |
| D | LYS63 | |
