Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4IHH

Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016020	cellular_component	membrane
A	0016410	molecular_function	N-acyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0042802	molecular_function	identical protein binding
A	0046677	biological_process	response to antibiotic
A	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0009245	biological_process	lipid A biosynthetic process
B	0016020	cellular_component	membrane
B	0016410	molecular_function	N-acyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0042802	molecular_function	identical protein binding
B	0046677	biological_process	response to antibiotic
B	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0009245	biological_process	lipid A biosynthetic process
C	0016020	cellular_component	membrane
C	0016410	molecular_function	N-acyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0042802	molecular_function	identical protein binding
C	0046677	biological_process	response to antibiotic
C	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0009245	biological_process	lipid A biosynthetic process
D	0016020	cellular_component	membrane
D	0016410	molecular_function	N-acyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0042802	molecular_function	identical protein binding
D	0046677	biological_process	response to antibiotic
D	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0009245	biological_process	lipid A biosynthetic process
E	0016020	cellular_component	membrane
E	0016410	molecular_function	N-acyltransferase activity
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0042802	molecular_function	identical protein binding
E	0046677	biological_process	response to antibiotic
E	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0009245	biological_process	lipid A biosynthetic process
F	0016020	cellular_component	membrane
F	0016410	molecular_function	N-acyltransferase activity
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0042802	molecular_function	identical protein binding
F	0046677	biological_process	response to antibiotic
F	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
G	0006633	biological_process	fatty acid biosynthetic process
H	0006633	biological_process	fatty acid biosynthetic process
I	0006633	biological_process	fatty acid biosynthetic process
J	0006633	biological_process	fatty acid biosynthetic process
K	0006633	biological_process	fatty acid biosynthetic process
L	0006633	biological_process	fatty acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MES A 401

Chain	Residue
A	SER30
A	MET31
A	THR40
A	PHE41
A	VAL43
A	ASN44
A	TYR47

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MES A 402

Chain	Residue
A	GLY257
A	HOH635
B	HOH510
A	PHE183
A	HIS239

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MES B 401

Chain	Residue
B	MET31
B	PHE41
B	VAL43
B	ASN44
B	TYR47
B	HOH641

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MES C 401

Chain	Residue
C	SER30
C	MET31
C	THR40
C	PHE41
C	VAL43
C	ASN44
C	HOH633

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MES D 401

Chain	Residue
D	SER30
D	MET31
D	THR40
D	PHE41
D	VAL43
D	ASN44
D	TYR47

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MES E 401

Chain	Residue
E	SER30
E	MET31
E	THR40
E	PHE41
E	MET42
E	VAL43
E	ASN44
E	TYR47

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MES F 401

Chain	Residue
F	SER30
F	MET31
F	THR40
F	PHE41
F	MET42
F	VAL43
F	ASN44
F	TYR47

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PNS G 101

Chain	Residue
A	THR286
A	GLY287
A	HOH535
B	ASN310
B	ARG314
C	VAL272
C	ASN274
C	MET290
C	MET292
G	SER36
G	HOH201

site_id	AC9
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PNS H 101

Chain	Residue
A	ASN310
A	ARG314
B	ASN274
B	MET290
B	VAL291
B	MET292
C	THR286
C	GLY287
H	SER36
H	HOH201
H	HOH202

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PNS I 101

Chain	Residue
D	ASN310
D	TRP313
D	ARG314
E	ASN274
E	MET290
E	MET292
F	THR286
F	GLY287
I	SER36

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PNS J 101

Chain	Residue
D	THR286
D	GLY287
E	ASN310
E	ARG314
F	ASN274
J	SER36
J	HOH201

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PNS K 101

Chain	Residue
D	ASN274
D	MET292
E	THR286
E	GLY287
F	ASN310
F	ARG314
K	SER36
K	HOH202
K	HOH203
K	HOH204

site_id	BC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PNS L 101

Chain	Residue
B	THR286
B	GLY287
C	ASN310
C	ARG314
L	SER36
L	HOH201
L	HOH202
A	VAL272
A	ASN274
A	MET292

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL

Chain	Residue	Details
G	ASP31-LEU46

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IApsAvIdatAkLGnnVsIGanAvIesgV

Chain	Residue	Details
A	ILE100-VAL128
A	ILE106-VAL134
A	LEU130-VAL158
A	ILE225-VAL253

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:18422345

Chain	Residue	Details
A	HIS239
B	HIS239
C	HIS239
D	HIS239
E	HIS239
F	HIS239

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Involved in determining the hydroxyacyl-ACP selectivity

Chain	Residue	Details
A	MET290
B	MET290
C	MET290
D	MET290
E	MET290
F	MET290

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)