4IHH
Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009245 | biological_process | lipid A biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009245 | biological_process | lipid A biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009245 | biological_process | lipid A biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009245 | biological_process | lipid A biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
| E | 0005515 | molecular_function | protein binding |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009245 | biological_process | lipid A biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
| F | 0005515 | molecular_function | protein binding |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009245 | biological_process | lipid A biosynthetic process |
| F | 0016740 | molecular_function | transferase activity |
| F | 0016747 | molecular_function | acyltransferase activity, transferring groups other than amino-acyl groups |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0103118 | molecular_function | UDP-3-O-[(3R)-3-hydroxyacyl]-glucosamine N-acyltransferase activity |
| G | 0006633 | biological_process | fatty acid biosynthetic process |
| H | 0006633 | biological_process | fatty acid biosynthetic process |
| I | 0006633 | biological_process | fatty acid biosynthetic process |
| J | 0006633 | biological_process | fatty acid biosynthetic process |
| K | 0006633 | biological_process | fatty acid biosynthetic process |
| L | 0006633 | biological_process | fatty acid biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MES A 401 |
| Chain | Residue |
| A | SER30 |
| A | MET31 |
| A | THR40 |
| A | PHE41 |
| A | VAL43 |
| A | ASN44 |
| A | TYR47 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MES A 402 |
| Chain | Residue |
| A | GLY257 |
| A | HOH635 |
| B | HOH510 |
| A | PHE183 |
| A | HIS239 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MES B 401 |
| Chain | Residue |
| B | MET31 |
| B | PHE41 |
| B | VAL43 |
| B | ASN44 |
| B | TYR47 |
| B | HOH641 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MES C 401 |
| Chain | Residue |
| C | SER30 |
| C | MET31 |
| C | THR40 |
| C | PHE41 |
| C | VAL43 |
| C | ASN44 |
| C | HOH633 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MES D 401 |
| Chain | Residue |
| D | SER30 |
| D | MET31 |
| D | THR40 |
| D | PHE41 |
| D | VAL43 |
| D | ASN44 |
| D | TYR47 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MES E 401 |
| Chain | Residue |
| E | SER30 |
| E | MET31 |
| E | THR40 |
| E | PHE41 |
| E | MET42 |
| E | VAL43 |
| E | ASN44 |
| E | TYR47 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MES F 401 |
| Chain | Residue |
| F | SER30 |
| F | MET31 |
| F | THR40 |
| F | PHE41 |
| F | MET42 |
| F | VAL43 |
| F | ASN44 |
| F | TYR47 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PNS G 101 |
| Chain | Residue |
| A | THR286 |
| A | GLY287 |
| A | HOH535 |
| B | ASN310 |
| B | ARG314 |
| C | VAL272 |
| C | ASN274 |
| C | MET290 |
| C | MET292 |
| G | SER36 |
| G | HOH201 |
| site_id | AC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE PNS H 101 |
| Chain | Residue |
| A | ASN310 |
| A | ARG314 |
| B | ASN274 |
| B | MET290 |
| B | VAL291 |
| B | MET292 |
| C | THR286 |
| C | GLY287 |
| H | SER36 |
| H | HOH201 |
| H | HOH202 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PNS I 101 |
| Chain | Residue |
| D | ASN310 |
| D | TRP313 |
| D | ARG314 |
| E | ASN274 |
| E | MET290 |
| E | MET292 |
| F | THR286 |
| F | GLY287 |
| I | SER36 |
| site_id | BC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PNS J 101 |
| Chain | Residue |
| D | THR286 |
| D | GLY287 |
| E | ASN310 |
| E | ARG314 |
| F | ASN274 |
| J | SER36 |
| J | HOH201 |
| site_id | BC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PNS K 101 |
| Chain | Residue |
| D | ASN274 |
| D | MET292 |
| E | THR286 |
| E | GLY287 |
| F | ASN310 |
| F | ARG314 |
| K | SER36 |
| K | HOH202 |
| K | HOH203 |
| K | HOH204 |
| site_id | BC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PNS L 101 |
| Chain | Residue |
| B | THR286 |
| B | GLY287 |
| C | ASN310 |
| C | ARG314 |
| L | SER36 |
| L | HOH201 |
| L | HOH202 |
| A | VAL272 |
| A | ASN274 |
| A | MET292 |
Functional Information from PROSITE/UniProt
| site_id | PS00012 |
| Number of Residues | 16 |
| Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL |
| Chain | Residue | Details |
| G | ASP31-LEU46 |
| site_id | PS00101 |
| Number of Residues | 29 |
| Details | HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IApsAvIdatAkLGnnVsIGanAvIesgV |
| Chain | Residue | Details |
| A | ILE100-VAL128 | |
| A | ILE106-VAL134 | |
| A | LEU130-VAL158 | |
| A | ILE225-VAL253 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"18422345","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Site: {"description":"Involved in determining the hydroxyacyl-ACP selectivity"} |
| Chain | Residue | Details |
