Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4IHG

Chasing Acyl Carrier Protein Through a Catalytic Cycle of Lipid A Production

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0009245	biological_process	lipid A biosynthetic process
A	0016410	molecular_function	N-acyltransferase activity
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0042802	molecular_function	identical protein binding
A	0046677	biological_process	response to antibiotic
A	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0009245	biological_process	lipid A biosynthetic process
B	0016410	molecular_function	N-acyltransferase activity
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
B	0042802	molecular_function	identical protein binding
B	0046677	biological_process	response to antibiotic
B	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0009245	biological_process	lipid A biosynthetic process
C	0016410	molecular_function	N-acyltransferase activity
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
C	0042802	molecular_function	identical protein binding
C	0046677	biological_process	response to antibiotic
C	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0009245	biological_process	lipid A biosynthetic process
D	0016410	molecular_function	N-acyltransferase activity
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
D	0042802	molecular_function	identical protein binding
D	0046677	biological_process	response to antibiotic
D	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0009245	biological_process	lipid A biosynthetic process
E	0016410	molecular_function	N-acyltransferase activity
E	0016740	molecular_function	transferase activity
E	0016746	molecular_function	acyltransferase activity
E	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
E	0042802	molecular_function	identical protein binding
E	0046677	biological_process	response to antibiotic
E	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0009245	biological_process	lipid A biosynthetic process
F	0016410	molecular_function	N-acyltransferase activity
F	0016740	molecular_function	transferase activity
F	0016746	molecular_function	acyltransferase activity
F	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
F	0042802	molecular_function	identical protein binding
F	0046677	biological_process	response to antibiotic
F	0103118	molecular_function	UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase activity
G	0006633	biological_process	fatty acid biosynthetic process
H	0006633	biological_process	fatty acid biosynthetic process
I	0006633	biological_process	fatty acid biosynthetic process
J	0006633	biological_process	fatty acid biosynthetic process
K	0006633	biological_process	fatty acid biosynthetic process
L	0006633	biological_process	fatty acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE FTT A 401

Chain	Residue
A	PHE183
A	ALA238
A	HIS239
A	ALA256
A	GLY257
A	VAL272
C	ASP232
I	PNS101

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE FTT B 401

Chain	Residue
A	GLY269
A	GLY287
B	PHE183
B	ALA238
B	HIS239
B	ILE254
B	MET255
B	ALA256
B	GLY257
B	ASN274
G	PNS101
A	ASP232

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FTT B 402

Chain	Residue
B	ALA248
B	MET266
B	ILE267
B	GLY268
B	THR284
C	PHE183
H	PNS101

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FTT C 401

Chain	Residue
B	ASP232
B	GLY269
C	PHE183
C	ALA238
C	HIS239
C	ILE254
C	MET255
C	GLY257
C	VAL272
C	HOH501
H	PNS101

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE FTT D 401

Chain	Residue
D	PHE183
D	GLN236
D	HIS239
D	ILE254
D	MET255
D	GLY257
D	VAL272
D	ILE273
D	HOH511
F	ASP232
F	GLY269
L	PNS101

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE FTT E 401

Chain	Residue
D	ASP232
D	GLY269
D	GLY287
E	PHE183
E	ALA238
E	HIS239
E	ILE254
E	GLY257
E	VAL272
E	HOH532
J	PNS101

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FTT E 402

Chain	Residue
D	ALA248
D	GLY268
E	PHE183
E	TYR185
J	PNS101

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE FTT F 401

Chain	Residue
E	ASP232
E	GLY251
F	GLN236
F	ALA238
F	HIS239
F	ILE254
F	MET255
F	ALA256
F	GLY257
F	ASN274
F	MET290
K	PNS101

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PNS G 101

Chain	Residue
A	GLY269
A	THR286
A	GLY287
B	FTT401
C	ASN310
C	ARG314
G	SER36

site_id	BC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PNS H 101

Chain	Residue
A	ASN310
A	TRP313
A	ARG314
B	ALA250
B	GLY268
B	GLY269
B	THR286
B	GLY287
B	FTT402
C	ASN274
C	FTT401
H	SER36

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PNS I 101

Chain	Residue
B	ASN310
B	ARG314
C	GLY269
C	THR286
C	GLY287
I	SER36
A	ASN274
A	FTT401

site_id	BC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PNS J 101

Chain	Residue
D	GLY268
D	GLY269
D	THR286
D	GLY287
E	PHE183
E	MET292
E	FTT401
E	FTT402
F	ASN310
F	ARG314
J	SER36

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PNS K 101

Chain	Residue
D	ASN310
D	ARG314
E	GLY269
E	THR286
E	GLY287
F	ASN274
F	MET292
F	FTT401
K	SER36

site_id	BC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PNS L 101

Chain	Residue
D	ASN274
D	FTT401
E	ASN310
E	TRP313
E	ARG314
F	GLY269
F	THR286
F	GLY287
L	SER36

Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDTVELVMAL

Chain	Residue	Details
G	ASP31-LEU46

site_id	PS00101
Number of Residues	29
Details	HEXAPEP_TRANSFERASES Hexapeptide-repeat containing-transferases signature. IApsAvIdatAkLGnnVsIGanAvIesgV

Chain	Residue	Details
A	ILE100-VAL128
A	ILE106-VAL134
A	LEU130-VAL158
A	ILE225-VAL253

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:18422345

Chain	Residue	Details
A	HIS239
B	HIS239
C	HIS239
D	HIS239
E	HIS239
F	HIS239

site_id	SWS_FT_FI2
Number of Residues	6
Details	SITE: Involved in determining the hydroxyacyl-ACP selectivity

Chain	Residue	Details
A	MET290
B	MET290
C	MET290
D	MET290
E	MET290
F	MET290

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)