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4IH7

Hepatitis C Virus polymerase NS5B (BK) with fragment-based compounds

Functional Information from GO Data
ChainGOidnamespacecontents
A0003723molecular_functionRNA binding
A0003968molecular_functionRNA-dependent RNA polymerase activity
A0039694biological_processviral RNA genome replication
B0003723molecular_functionRNA binding
B0003968molecular_functionRNA-dependent RNA polymerase activity
B0039694biological_processviral RNA genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE ZN A 601
ChainResidue
AASP66
BHIS1

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 1ER A 602
ChainResidue
AILE447
ATYR448
AARG200
ACYS366
ASER368
AASN411
AMET414
ATYR415
AGLN446

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE ZN B 601
ChainResidue
AHIS1
BASP66
BHOH780

site_idAC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE 1ER B 602
ChainResidue
BARG200
BSER368
BGLY410
BASN411
BMET414
BGLN446
BILE447
BTYR448
BHOH715

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572
ChainResidueDetails
AASP220
AASP318
AASP319
BASP220
BASP318
BASP319

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662
ChainResidueDetails
ASER29
ASER42
BSER29
BSER42

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PDB entries from 2024-11-06

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