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4IGG

Full-length human alpha-catenin crystal structure

Functional Information from GO Data
ChainGOidnamespacecontents
A0001541biological_processovarian follicle development
A0001669cellular_componentacrosomal vesicle
A0003723molecular_functionRNA binding
A0005198molecular_functionstructural molecule activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005912cellular_componentadherens junction
A0005915cellular_componentzonula adherens
A0005925cellular_componentfocal adhesion
A0006915biological_processapoptotic process
A0007155biological_processcell adhesion
A0007163biological_processestablishment or maintenance of cell polarity
A0007224biological_processsmoothened signaling pathway
A0007229biological_processintegrin-mediated signaling pathway
A0007405biological_processneuroblast proliferation
A0007406biological_processnegative regulation of neuroblast proliferation
A0008013molecular_functionbeta-catenin binding
A0008104biological_processprotein localization
A0008584biological_processmale gonad development
A0014070biological_processresponse to organic cyclic compound
A0014704cellular_componentintercalated disc
A0015629cellular_componentactin cytoskeleton
A0016264biological_processgap junction assembly
A0016342cellular_componentcatenin complex
A0016477biological_processcell migration
A0016600cellular_componentflotillin complex
A0017166molecular_functionvinculin binding
A0030027cellular_componentlamellipodium
A0030054cellular_componentcell junction
A0031103biological_processaxon regeneration
A0042127biological_processregulation of cell population proliferation
A0042475biological_processodontogenesis of dentin-containing tooth
A0042802molecular_functionidentical protein binding
A0043066biological_processnegative regulation of apoptotic process
A0043231cellular_componentintracellular membrane-bounded organelle
A0043297biological_processapical junction assembly
A0043627biological_processresponse to estrogen
A0044877molecular_functionprotein-containing complex binding
A0045295molecular_functiongamma-catenin binding
A0045296molecular_functioncadherin binding
A0045880biological_processpositive regulation of smoothened signaling pathway
A0048870biological_processcell motility
A0051015molecular_functionactin filament binding
A0070161cellular_componentanchoring junction
A0071681biological_processcellular response to indole-3-methanol
A0090136biological_processepithelial cell-cell adhesion
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0098609biological_processcell-cell adhesion
A1900181biological_processnegative regulation of protein localization to nucleus
A2000146biological_processnegative regulation of cell motility
A2001045biological_processnegative regulation of integrin-mediated signaling pathway
A2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
A2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
B0001541biological_processovarian follicle development
B0001669cellular_componentacrosomal vesicle
B0003723molecular_functionRNA binding
B0005198molecular_functionstructural molecule activity
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005912cellular_componentadherens junction
B0005915cellular_componentzonula adherens
B0005925cellular_componentfocal adhesion
B0006915biological_processapoptotic process
B0007155biological_processcell adhesion
B0007163biological_processestablishment or maintenance of cell polarity
B0007224biological_processsmoothened signaling pathway
B0007229biological_processintegrin-mediated signaling pathway
B0007405biological_processneuroblast proliferation
B0007406biological_processnegative regulation of neuroblast proliferation
B0008013molecular_functionbeta-catenin binding
B0008104biological_processprotein localization
B0008584biological_processmale gonad development
B0014070biological_processresponse to organic cyclic compound
B0014704cellular_componentintercalated disc
B0015629cellular_componentactin cytoskeleton
B0016264biological_processgap junction assembly
B0016342cellular_componentcatenin complex
B0016477biological_processcell migration
B0016600cellular_componentflotillin complex
B0017166molecular_functionvinculin binding
B0030027cellular_componentlamellipodium
B0030054cellular_componentcell junction
B0031103biological_processaxon regeneration
B0042127biological_processregulation of cell population proliferation
B0042475biological_processodontogenesis of dentin-containing tooth
B0042802molecular_functionidentical protein binding
B0043066biological_processnegative regulation of apoptotic process
B0043231cellular_componentintracellular membrane-bounded organelle
B0043297biological_processapical junction assembly
B0043627biological_processresponse to estrogen
B0044877molecular_functionprotein-containing complex binding
B0045295molecular_functiongamma-catenin binding
B0045296molecular_functioncadherin binding
B0045880biological_processpositive regulation of smoothened signaling pathway
B0048870biological_processcell motility
B0051015molecular_functionactin filament binding
B0070161cellular_componentanchoring junction
B0071681biological_processcellular response to indole-3-methanol
B0090136biological_processepithelial cell-cell adhesion
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0098609biological_processcell-cell adhesion
B1900181biological_processnegative regulation of protein localization to nucleus
B2000146biological_processnegative regulation of cell motility
B2001045biological_processnegative regulation of integrin-mediated signaling pathway
B2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
B2001241biological_processpositive regulation of extrinsic apoptotic signaling pathway in absence of ligand
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE PO4 A 1001
ChainResidue
ALYS178
AARG329
ALYS384

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 B 1001
ChainResidue
BLYS178
BARG329
BGLN381
BLYS384

Functional Information from PROSITE/UniProt
site_idPS00663
Number of Residues21
DetailsVINCULIN_1 Vinculin family talin-binding region signature. KaLkpeVdkLnimaakRQQEL
ChainResidueDetails
ALYS178-LEU198

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER264
BSER851
ASER268
ASER295
ASER297
ASER851
BSER264
BSER268
BSER295
BSER297

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:24275569
ChainResidueDetails
ATHR634
BTHR634

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:25653389, ECO:0007744|PubMed:16807684, ECO:0007744|PubMed:17081983, ECO:0007744|PubMed:18220336, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER641
BSER641

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:18318008
ChainResidueDetails
ATHR645
BTHR645

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CK1 => ECO:0000269|PubMed:25653389, ECO:0007744|PubMed:17487921, ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:21406692
ChainResidueDetails
ASER652
BSER652

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: Phosphoserine; by CK1 => ECO:0000269|PubMed:25653389
ChainResidueDetails
ASER655
BSER655

site_idSWS_FT_FI7
Number of Residues2
DetailsMOD_RES: Phosphothreonine; by CK1 => ECO:0000269|PubMed:25653389
ChainResidueDetails
ATHR658
BTHR658

site_idSWS_FT_FI8
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS797
BLYS797

223166

PDB entries from 2024-07-31

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