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4ICK

Crystal structure of human AP4A hydrolase E58A mutant

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004081molecular_functionbis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005759cellular_componentmitochondrial matrix
A0006139biological_processnucleobase-containing compound metabolic process
A0006167biological_processAMP biosynthetic process
A0006754biological_processATP biosynthetic process
A0006915biological_processapoptotic process
A0008796molecular_functionbis(5'-nucleosyl)-tetraphosphatase activity
A0008803molecular_functionbis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
A0016787molecular_functionhydrolase activity
A0034599biological_processcellular response to oxidative stress
B0000166molecular_functionnucleotide binding
B0004081molecular_functionbis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005759cellular_componentmitochondrial matrix
B0006139biological_processnucleobase-containing compound metabolic process
B0006167biological_processAMP biosynthetic process
B0006754biological_processATP biosynthetic process
B0006915biological_processapoptotic process
B0008796molecular_functionbis(5'-nucleosyl)-tetraphosphatase activity
B0008803molecular_functionbis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity
B0016787molecular_functionhydrolase activity
B0034599biological_processcellular response to oxidative stress
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL A 201
ChainResidue
AASN22
AALA23
AILE24
AGLU46
AHIS139
AHOH314

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE PO4 B 201
ChainResidue
BTYR114
BTRP116
BHOH301
BHOH303
BHOH304
BHOH305
AARG12
ATRP116
AHOH318

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 202
ChainResidue
AASP50
AGLU53
AGLN140
BLYS77
BTRP94

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.5
ChainResidueDetails
AALA2
BALA2

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PDB entries from 2025-07-02

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