4I8C
X-ray structure of NikA in complex with Ni-(L-His)2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0015675 | biological_process | nickel cation transport |
| A | 0015833 | biological_process | peptide transport |
| A | 0016020 | cellular_component | membrane |
| A | 0016151 | molecular_function | nickel cation binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| A | 0042597 | cellular_component | periplasmic space |
| A | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| A | 0046914 | molecular_function | transition metal ion binding |
| A | 0050919 | biological_process | negative chemotaxis |
| A | 0051540 | molecular_function | metal cluster binding |
| A | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0098716 | biological_process | nickel cation import across plasma membrane |
| A | 1904680 | molecular_function | peptide transmembrane transporter activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0015675 | biological_process | nickel cation transport |
| B | 0015833 | biological_process | peptide transport |
| B | 0016020 | cellular_component | membrane |
| B | 0016151 | molecular_function | nickel cation binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| B | 0042597 | cellular_component | periplasmic space |
| B | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| B | 0046914 | molecular_function | transition metal ion binding |
| B | 0050919 | biological_process | negative chemotaxis |
| B | 0051540 | molecular_function | metal cluster binding |
| B | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| B | 0055085 | biological_process | transmembrane transport |
| B | 0098716 | biological_process | nickel cation import across plasma membrane |
| B | 1904680 | molecular_function | peptide transmembrane transporter activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0015675 | biological_process | nickel cation transport |
| C | 0015833 | biological_process | peptide transport |
| C | 0016020 | cellular_component | membrane |
| C | 0016151 | molecular_function | nickel cation binding |
| C | 0020037 | molecular_function | heme binding |
| C | 0030288 | cellular_component | outer membrane-bounded periplasmic space |
| C | 0042597 | cellular_component | periplasmic space |
| C | 0043190 | cellular_component | ATP-binding cassette (ABC) transporter complex |
| C | 0046914 | molecular_function | transition metal ion binding |
| C | 0050919 | biological_process | negative chemotaxis |
| C | 0051540 | molecular_function | metal cluster binding |
| C | 0055052 | cellular_component | ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0098716 | biological_process | nickel cation import across plasma membrane |
| C | 1904680 | molecular_function | peptide transmembrane transporter activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE HIS A 601 |
| Chain | Residue |
| A | TYR22 |
| A | TRP100 |
| A | ARG137 |
| A | TRP398 |
| A | HIS416 |
| A | HIS602 |
| A | NI603 |
| A | HOH717 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HIS A 602 |
| Chain | Residue |
| A | ARG97 |
| A | ARG137 |
| A | TYR382 |
| A | ARG386 |
| A | HIS416 |
| A | HIS601 |
| A | NI603 |
| A | ACT604 |
| A | THR23 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI A 603 |
| Chain | Residue |
| A | HIS416 |
| A | HIS601 |
| A | HIS602 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 604 |
| Chain | Residue |
| A | THR23 |
| A | GLU378 |
| A | HIS602 |
| A | HOH714 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 605 |
| Chain | Residue |
| A | GLN385 |
| A | HIS395 |
| A | HIS416 |
| A | HOH841 |
| A | HOH843 |
| A | HOH844 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT A 606 |
| Chain | Residue |
| A | TYR127 |
| A | ARG447 |
| A | HOH827 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 607 |
| Chain | Residue |
| A | THR203 |
| A | ASP227 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 608 |
| Chain | Residue |
| A | PRO159 |
| A | LEU167 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT A 609 |
| Chain | Residue |
| A | ARG68 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT A 610 |
| Chain | Residue |
| A | ASN149 |
| A | LYS157 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 611 |
| Chain | Residue |
| A | TRP10 |
| A | PRO11 |
| A | GLY219 |
| A | ASN220 |
| A | GLY222 |
| A | LEU223 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 612 |
| Chain | Residue |
| A | GLN361 |
| A | SER372 |
| A | LEU373 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 613 |
| Chain | Residue |
| A | LYS276 |
| A | GLU320 |
| A | THR325 |
| A | LEU326 |
| A | ARG333 |
| B | LYS276 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HIS B 601 |
| Chain | Residue |
| B | TYR22 |
| B | TRP100 |
| B | ARG137 |
| B | TRP398 |
| B | TYR402 |
| B | HIS416 |
| B | HIS602 |
| B | NI603 |
| B | HOH706 |
| B | HOH806 |
| site_id | BC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HIS B 602 |
| Chain | Residue |
| B | TYR22 |
| B | THR23 |
| B | ARG97 |
| B | ARG137 |
| B | TYR382 |
| B | ARG386 |
| B | HIS416 |
| B | HIS601 |
| B | NI603 |
| B | HOH825 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI B 603 |
| Chain | Residue |
| B | HIS416 |
| B | HIS601 |
| B | HIS602 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL B 604 |
| Chain | Residue |
| B | LEU293 |
| B | HIS459 |
| B | HOH728 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 605 |
| Chain | Residue |
| B | SER57 |
| B | GLU58 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT B 606 |
| Chain | Residue |
| B | TRP54 |
| site_id | CC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 607 |
| Chain | Residue |
| B | THR441 |
| B | HIS442 |
| site_id | CC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 608 |
| Chain | Residue |
| B | ASN149 |
| B | LYS157 |
| site_id | CC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACT B 609 |
| Chain | Residue |
| B | GLU434 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL B 610 |
| Chain | Residue |
| B | ASN220 |
| B | ALA489 |
| B | THR490 |
| B | HOH766 |
| B | HOH796 |
| site_id | CC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL B 611 |
| Chain | Residue |
| B | ARG68 |
| site_id | CC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL B 612 |
| Chain | Residue |
| B | LEU303 |
| B | GLY304 |
| A | PHE229 |
| A | SER233 |
| A | LEU242 |
| B | ASN302 |
| site_id | CC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 613 |
| Chain | Residue |
| B | TYR382 |
| B | GLN385 |
| B | PHE394 |
| B | HIS395 |
| B | ARG396 |
| B | HIS416 |
| B | HOH755 |
| site_id | CC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT B 614 |
| Chain | Residue |
| B | ARG341 |
| C | LYS433 |
| site_id | DC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HIS C 601 |
| Chain | Residue |
| C | TYR22 |
| C | MET27 |
| C | TRP100 |
| C | ARG137 |
| C | TRP398 |
| C | TYR402 |
| C | HIS416 |
| C | HIS602 |
| C | NI603 |
| C | HOH709 |
| site_id | DC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HIS C 602 |
| Chain | Residue |
| C | THR23 |
| C | ARG97 |
| C | ARG137 |
| C | TYR382 |
| C | ARG386 |
| C | HIS416 |
| C | HIS601 |
| C | NI603 |
| C | HOH711 |
| C | HOH756 |
| site_id | DC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI C 603 |
| Chain | Residue |
| C | HIS416 |
| C | HIS601 |
| C | HIS602 |
| site_id | DC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT C 604 |
| Chain | Residue |
| C | LYS275 |
| C | LYS276 |
| site_id | DC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT C 605 |
| Chain | Residue |
| A | ARG95 |
| C | HIS442 |
| site_id | DC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT C 606 |
| Chain | Residue |
| C | TYR382 |
| C | GLN385 |
| C | PHE394 |
| C | HIS395 |
| C | ARG396 |
| C | HIS416 |
| C | HOH755 |
| site_id | DC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL C 607 |
| Chain | Residue |
| C | GLN361 |
| C | ASP370 |
| C | VAL371 |
| C | SER372 |
| C | LEU373 |
| site_id | DC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C 608 |
| Chain | Residue |
| B | ASN261 |
| C | ASN261 |
| C | HOH738 |
| site_id | DC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 609 |
| Chain | Residue |
| B | LYS433 |
| C | ARG341 |
Functional Information from PROSITE/UniProt
| site_id | PS01040 |
| Number of Residues | 23 |
| Details | SBP_BACTERIAL_5 Bacterial extracellular solute-binding proteins, family 5 signature. AkswthseDgkTWtFtLRDDVKF |
| Chain | Residue | Details |
| A | ALA51-PHE73 |
