4I73
Crystal structure of the Trypanosoma brucei Inosine-Adenosine-Guanosine nucleoside hydrolase in complex with compound UAMC-00312
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006152 | biological_process | purine nucleoside catabolic process |
| A | 0006166 | biological_process | purine ribonucleoside salvage |
| A | 0008477 | molecular_function | purine nucleosidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| A | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| A | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| A | 0020015 | cellular_component | glycosome |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006152 | biological_process | purine nucleoside catabolic process |
| B | 0006166 | biological_process | purine ribonucleoside salvage |
| B | 0008477 | molecular_function | purine nucleosidase activity |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| B | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| B | 0020015 | cellular_component | glycosome |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006152 | biological_process | purine nucleoside catabolic process |
| C | 0006166 | biological_process | purine ribonucleoside salvage |
| C | 0008477 | molecular_function | purine nucleosidase activity |
| C | 0016787 | molecular_function | hydrolase activity |
| C | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| C | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| C | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| C | 0020015 | cellular_component | glycosome |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0006152 | biological_process | purine nucleoside catabolic process |
| D | 0006166 | biological_process | purine ribonucleoside salvage |
| D | 0008477 | molecular_function | purine nucleosidase activity |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| D | 0016799 | molecular_function | hydrolase activity, hydrolyzing N-glycosyl compounds |
| D | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| D | 0020015 | cellular_component | glycosome |
| D | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 401 |
| Chain | Residue |
| A | ASP10 |
| A | ASP15 |
| A | THR137 |
| A | ASP261 |
| A | MBY402 |
| A | HOH566 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE MBY A 402 |
| Chain | Residue |
| A | PHE79 |
| A | TRP83 |
| A | THR137 |
| A | ASN173 |
| A | GLU184 |
| A | ASN186 |
| A | ARG252 |
| A | TRP260 |
| A | ASP261 |
| A | CA401 |
| A | HOH566 |
| A | HOH694 |
| A | ASP14 |
| A | ASP15 |
| A | ASP40 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 403 |
| Chain | Residue |
| A | ASP253 |
| A | HOH627 |
| A | HOH628 |
| A | HOH635 |
| B | HIS58 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 404 |
| Chain | Residue |
| A | HIS58 |
| A | HOH630 |
| A | HOH631 |
| A | HOH696 |
| B | ASP253 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NI A 405 |
| Chain | Residue |
| A | HOH626 |
| A | HOH632 |
| A | HOH633 |
| A | HOH634 |
| B | LYS287 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI A 406 |
| Chain | Residue |
| A | SER-1 |
| A | GLY-2 |
| A | HIS0 |
| site_id | AC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI A 407 |
| Chain | Residue |
| D | HIS58 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI A 408 |
| Chain | Residue |
| A | HIS115 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 401 |
| Chain | Residue |
| B | ASP10 |
| B | ASP15 |
| B | THR137 |
| B | ASP261 |
| B | MBY402 |
| B | HOH508 |
| site_id | BC1 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE MBY B 402 |
| Chain | Residue |
| B | ASP14 |
| B | ASP15 |
| B | ASP40 |
| B | PHE79 |
| B | TRP83 |
| B | THR137 |
| B | ASN173 |
| B | GLU184 |
| B | ASN186 |
| B | ARG252 |
| B | TRP260 |
| B | ASP261 |
| B | CA401 |
| B | HOH508 |
| B | HOH587 |
| site_id | BC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI B 403 |
| Chain | Residue |
| B | HIS115 |
| B | HOH655 |
| B | HOH676 |
| site_id | BC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI B 404 |
| Chain | Residue |
| B | HIS317 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA C 401 |
| Chain | Residue |
| C | ASP10 |
| C | ASP15 |
| C | THR137 |
| C | ASP261 |
| C | MBY402 |
| C | NI406 |
| C | HOH517 |
| site_id | BC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE MBY C 402 |
| Chain | Residue |
| C | ASP14 |
| C | ASP15 |
| C | ASP40 |
| C | PHE79 |
| C | TRP83 |
| C | THR137 |
| C | ASN173 |
| C | GLU184 |
| C | ASN186 |
| C | TRP260 |
| C | ASP261 |
| C | CA401 |
| C | HOH517 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI C 403 |
| Chain | Residue |
| C | HIS58 |
| D | LEU251 |
| D | ASP253 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE NI C 404 |
| Chain | Residue |
| C | GLY-2 |
| C | SER-1 |
| C | HIS0 |
| C | MET1 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI C 405 |
| Chain | Residue |
| C | HIS115 |
| site_id | BC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI C 406 |
| Chain | Residue |
| C | ASP14 |
| C | TRP260 |
| C | CA401 |
| site_id | CC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI C 407 |
| Chain | Residue |
| C | HIS317 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 401 |
| Chain | Residue |
| D | ASP15 |
| D | THR137 |
| D | ASP261 |
| D | MBY402 |
| D | HOH521 |
| D | ASP10 |
| site_id | CC3 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE MBY D 402 |
| Chain | Residue |
| D | ASP14 |
| D | ASP15 |
| D | ASP40 |
| D | PHE79 |
| D | TRP83 |
| D | THR137 |
| D | ASN173 |
| D | GLU184 |
| D | ASN186 |
| D | ARG252 |
| D | TRP260 |
| D | ASP261 |
| D | CA401 |
| D | HOH521 |
| D | HOH626 |
| site_id | CC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE NI D 403 |
| Chain | Residue |
| D | HIS115 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NI D 404 |
| Chain | Residue |
| D | GLY-2 |
| D | SER-1 |
| D | HIS0 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NI D 405 |
| Chain | Residue |
| D | ASP14 |
| D | TRP260 |
