4I1H

Structure of Parkin E3 ligase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0016567	biological_process	protein ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS150
A	CYS154
A	CYS212
A	HIS215

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS166
A	CYS169
A	CYS196
A	CYS201

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 503

Chain	Residue
A	CYS241
A	CYS260
A	CYS263
A	CYS238

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 504

Chain	Residue
A	CYS253
A	HIS257
A	CYS289
A	CYS293

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 505

Chain	Residue
A	CYS332
A	CYS337
A	CYS352
A	CYS360

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 506

Chain	Residue
A	CYS365
A	CYS368
A	HIS373
A	CYS377

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 507

Chain	Residue
A	CYS418
A	CYS421
A	CYS436
A	CYS441

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 508

Chain	Residue
A	CYS446
A	CYS449
A	CYS457
A	HIS461

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	ZN_FING: RING-type 0; atypical

Chain	Residue	Details
A	SER141-ALA225

---

site_id	SWS_FT_FI2
Number of Residues	55
Details	ZN_FING: RING-type 1 => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS238-CYS293

---

site_id	SWS_FT_FI3
Number of Residues	64
Details	ZN_FING: IBR-type => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	ASN313-CYS377

---

site_id	SWS_FT_FI4
Number of Residues	31
Details	ZN_FING: RING-type 2; atypical => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS418-CYS449

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23770917

Chain	Residue	Details
A	CYS431

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221

Chain	Residue	Details
A	CYS238
A	CYS449
A	CYS457
A	HIS461
A	CYS241
A	CYS253
A	HIS257
A	CYS260
A	CYS263
A	CYS289
A	CYS293
A	HIS373

---

site_id	SWS_FT_FI7
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01221, ECO:0000269|PubMed:23770917

Chain	Residue	Details
A	CYS332
A	CYS436
A	CYS441
A	CYS446
A	CYS337
A	CYS352
A	CYS360
A	CYS365
A	CYS368
A	CYS377
A	CYS418
A	CYS421

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by PINK1 => ECO:0000269|PubMed:18957282

Chain	Residue	Details
A	THR175

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:18957282

Chain	Residue	Details
A	THR217

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15) => ECO:0000269|PubMed:27534820

Chain	Residue	Details
A	LYS349
A	LYS369

---