4I1F

Structure of Parkin-S223P E3 ligase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0008270	molecular_function	zinc ion binding
A	0016567	biological_process	protein ubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 501

Chain	Residue
A	CYS150
A	CYS154
A	CYS212
A	HIS215

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	CYS166
A	CYS169
A	CYS196
A	CYS201

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 503

Chain	Residue
A	CYS241
A	CYS260
A	CYS263
A	CYS238

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 504

Chain	Residue
A	CYS253
A	HIS257
A	CYS289
A	CYS293

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 505

Chain	Residue
A	CYS332
A	CYS337
A	CYS352
A	CYS360

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 506

Chain	Residue
A	CYS365
A	CYS368
A	HIS373
A	CYS377

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 507

Chain	Residue
A	CYS418
A	CYS421
A	CYS436
A	CYS441

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 508

Chain	Residue
A	CYS446
A	CYS449
A	CYS457
A	HIS461

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BA A 509

Chain	Residue
A	CYS196
A	SER198
A	CYS201
A	HOH816

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	55
Details	Zinc finger: {"description":"RING-type 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	31
Details	Zinc finger: {"description":"RING-type 2; atypical","evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Region: {"description":"SYT11 binding 2","evidences":[{"source":"PubMed","id":"12925569","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23770917","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01221","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23770917","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by PINK1","evidences":[{"source":"PubMed","id":"18957282","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18957282","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ISG15)","evidences":[{"source":"PubMed","id":"27534820","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---