Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4I0U

Improved structure of Thermotoga maritima CorA at 2.7 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006824	biological_process	cobalt ion transport
A	0015087	molecular_function	cobalt ion transmembrane transporter activity
A	0015095	molecular_function	magnesium ion transmembrane transporter activity
A	0015693	biological_process	magnesium ion transport
A	0016020	cellular_component	membrane
A	0030001	biological_process	metal ion transport
A	0046872	molecular_function	metal ion binding
A	0046873	molecular_function	metal ion transmembrane transporter activity
A	0050897	molecular_function	cobalt ion binding
A	0051260	biological_process	protein homooligomerization
A	0055085	biological_process	transmembrane transport
A	1903830	biological_process	magnesium ion transmembrane transport
B	0000287	molecular_function	magnesium ion binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006824	biological_process	cobalt ion transport
B	0015087	molecular_function	cobalt ion transmembrane transporter activity
B	0015095	molecular_function	magnesium ion transmembrane transporter activity
B	0015693	biological_process	magnesium ion transport
B	0016020	cellular_component	membrane
B	0030001	biological_process	metal ion transport
B	0046872	molecular_function	metal ion binding
B	0046873	molecular_function	metal ion transmembrane transporter activity
B	0050897	molecular_function	cobalt ion binding
B	0051260	biological_process	protein homooligomerization
B	0055085	biological_process	transmembrane transport
B	1903830	biological_process	magnesium ion transmembrane transport
C	0000287	molecular_function	magnesium ion binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006824	biological_process	cobalt ion transport
C	0015087	molecular_function	cobalt ion transmembrane transporter activity
C	0015095	molecular_function	magnesium ion transmembrane transporter activity
C	0015693	biological_process	magnesium ion transport
C	0016020	cellular_component	membrane
C	0030001	biological_process	metal ion transport
C	0046872	molecular_function	metal ion binding
C	0046873	molecular_function	metal ion transmembrane transporter activity
C	0050897	molecular_function	cobalt ion binding
C	0051260	biological_process	protein homooligomerization
C	0055085	biological_process	transmembrane transport
C	1903830	biological_process	magnesium ion transmembrane transport
D	0000287	molecular_function	magnesium ion binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006824	biological_process	cobalt ion transport
D	0015087	molecular_function	cobalt ion transmembrane transporter activity
D	0015095	molecular_function	magnesium ion transmembrane transporter activity
D	0015693	biological_process	magnesium ion transport
D	0016020	cellular_component	membrane
D	0030001	biological_process	metal ion transport
D	0046872	molecular_function	metal ion binding
D	0046873	molecular_function	metal ion transmembrane transporter activity
D	0050897	molecular_function	cobalt ion binding
D	0051260	biological_process	protein homooligomerization
D	0055085	biological_process	transmembrane transport
D	1903830	biological_process	magnesium ion transmembrane transport
E	0000287	molecular_function	magnesium ion binding
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006824	biological_process	cobalt ion transport
E	0015087	molecular_function	cobalt ion transmembrane transporter activity
E	0015095	molecular_function	magnesium ion transmembrane transporter activity
E	0015693	biological_process	magnesium ion transport
E	0016020	cellular_component	membrane
E	0030001	biological_process	metal ion transport
E	0046872	molecular_function	metal ion binding
E	0046873	molecular_function	metal ion transmembrane transporter activity
E	0050897	molecular_function	cobalt ion binding
E	0051260	biological_process	protein homooligomerization
E	0055085	biological_process	transmembrane transport
E	1903830	biological_process	magnesium ion transmembrane transport
F	0000287	molecular_function	magnesium ion binding
F	0005886	cellular_component	plasma membrane
F	0006811	biological_process	monoatomic ion transport
F	0006824	biological_process	cobalt ion transport
F	0015087	molecular_function	cobalt ion transmembrane transporter activity
F	0015095	molecular_function	magnesium ion transmembrane transporter activity
F	0015693	biological_process	magnesium ion transport
F	0016020	cellular_component	membrane
F	0030001	biological_process	metal ion transport
F	0046872	molecular_function	metal ion binding
F	0046873	molecular_function	metal ion transmembrane transporter activity
F	0050897	molecular_function	cobalt ion binding
F	0051260	biological_process	protein homooligomerization
F	0055085	biological_process	transmembrane transport
F	1903830	biological_process	magnesium ion transmembrane transport
G	0000287	molecular_function	magnesium ion binding
G	0005886	cellular_component	plasma membrane
G	0006811	biological_process	monoatomic ion transport
G	0006824	biological_process	cobalt ion transport
G	0015087	molecular_function	cobalt ion transmembrane transporter activity
G	0015095	molecular_function	magnesium ion transmembrane transporter activity
G	0015693	biological_process	magnesium ion transport
G	0016020	cellular_component	membrane
G	0030001	biological_process	metal ion transport
G	0046872	molecular_function	metal ion binding
G	0046873	molecular_function	metal ion transmembrane transporter activity
G	0050897	molecular_function	cobalt ion binding
G	0051260	biological_process	protein homooligomerization
G	0055085	biological_process	transmembrane transport
G	1903830	biological_process	magnesium ion transmembrane transport
H	0000287	molecular_function	magnesium ion binding
H	0005886	cellular_component	plasma membrane
H	0006811	biological_process	monoatomic ion transport
H	0006824	biological_process	cobalt ion transport
H	0015087	molecular_function	cobalt ion transmembrane transporter activity
H	0015095	molecular_function	magnesium ion transmembrane transporter activity
H	0015693	biological_process	magnesium ion transport
H	0016020	cellular_component	membrane
H	0030001	biological_process	metal ion transport
H	0046872	molecular_function	metal ion binding
H	0046873	molecular_function	metal ion transmembrane transporter activity
H	0050897	molecular_function	cobalt ion binding
H	0051260	biological_process	protein homooligomerization
H	0055085	biological_process	transmembrane transport
H	1903830	biological_process	magnesium ion transmembrane transport
I	0000287	molecular_function	magnesium ion binding
I	0005886	cellular_component	plasma membrane
I	0006811	biological_process	monoatomic ion transport
I	0006824	biological_process	cobalt ion transport
I	0015087	molecular_function	cobalt ion transmembrane transporter activity
I	0015095	molecular_function	magnesium ion transmembrane transporter activity
I	0015693	biological_process	magnesium ion transport
I	0016020	cellular_component	membrane
I	0030001	biological_process	metal ion transport
I	0046872	molecular_function	metal ion binding
I	0046873	molecular_function	metal ion transmembrane transporter activity
I	0050897	molecular_function	cobalt ion binding
I	0051260	biological_process	protein homooligomerization
I	0055085	biological_process	transmembrane transport
I	1903830	biological_process	magnesium ion transmembrane transport
J	0000287	molecular_function	magnesium ion binding
J	0005886	cellular_component	plasma membrane
J	0006811	biological_process	monoatomic ion transport
J	0006824	biological_process	cobalt ion transport
J	0015087	molecular_function	cobalt ion transmembrane transporter activity
J	0015095	molecular_function	magnesium ion transmembrane transporter activity
J	0015693	biological_process	magnesium ion transport
J	0016020	cellular_component	membrane
J	0030001	biological_process	metal ion transport
J	0046872	molecular_function	metal ion binding
J	0046873	molecular_function	metal ion transmembrane transporter activity
J	0050897	molecular_function	cobalt ion binding
J	0051260	biological_process	protein homooligomerization
J	0055085	biological_process	transmembrane transport
J	1903830	biological_process	magnesium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG A 401

Chain	Residue
A	HOH506
A	HOH507
D	HOH501
D	HOH502

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 402

Chain	Residue
A	ARG153
A	ILE160
A	ILE161
A	TYR168
B	PRO14

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LMT A 403

Chain	Residue
A	TYR311
A	GLU320
B	LEU331
B	LMT406

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG B 401

Chain	Residue
A	HOH501
A	HOH502
A	HOH503
B	HOH501

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 402

Chain	Residue
A	ASP253
A	HOH504
A	HOH505
B	ASP89
B	HOH502
B	HOH503

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 403

Chain	Residue
B	ASP253
B	HOH506
C	ASP89
C	HOH503
C	HOH504
C	HOH505

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL B 404

Chain	Residue
B	GLY159
B	ILE160
B	ILE161
B	TYR168
B	HOH510
C	PRO14

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL B 405

Chain	Residue
A	HOH502
B	LYS9
B	GLU88
B	ASN92

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT B 406

Chain	Residue
A	LMT403

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE LMT B 407

Chain	Residue
B	TRP323

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG B 408

Chain	Residue
B	GLN74
B	GLU78
B	HOH526

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG B 409

Chain	Residue
B	GLN74
J	GLU197

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG B 410

Chain	Residue
B	GLU28
B	LYS43

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG B 411

Chain	Residue
B	ASP55

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MG C 401

Chain	Residue
B	HOH504
B	HOH505
C	HOH501
C	HOH502

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 402

Chain	Residue
C	ASP179
C	HOH506
C	HOH507
C	HOH508
E	HOH501
E	HOH502

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 403

Chain	Residue
C	LYS9
C	GLU88
C	ASN92
C	HOH503

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 404

Chain	Residue
C	TYR168
E	PRO14

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG C 405

Chain	Residue
E	PEG406

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PEG C 406

Chain	Residue
B	ARG252
C	VAL99
C	GLU100
C	PHE101
C	SER234

site_id	CC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG D 402

Chain	Residue
A	ASP89
A	HOH508
A	HOH509
D	ASP253
D	HIS257
D	HOH503
D	HOH504

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 403

Chain	Residue
D	LEU85
D	ASP89
D	HOH507
D	HOH508
E	ASP253
E	HOH507

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 404

Chain	Residue
D	LYS9
D	GLU88
D	ASN92

site_id	CC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG D 405

Chain	Residue
D	ASP148

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E 401

Chain	Residue
C	ASP253
C	HOH509
E	ASP89
E	HOH503
E	HOH504
E	HOH505

site_id	CC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E 402

Chain	Residue
D	HOH505
D	HOH506
E	HOH506

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 403

Chain	Residue
E	ILE160
E	TYR168
D	PRO14
E	ARG153

site_id	DC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 404

Chain	Residue
E	LYS9
E	GLU88
E	ASN92
E	HOH503

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG E 405

Chain	Residue
E	GLU197
E	GLU201
G	ASP71
G	HOH535

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG E 406

Chain	Residue
C	PEG405
E	PRO328
E	PEG407

site_id	DC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG E 407

Chain	Residue
E	PRO328
E	PEG406

site_id	DC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG E 408

Chain	Residue
E	LYS117
E	GLU186
E	ASP190

site_id	DC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PG0 E 409

Chain	Residue
E	GLU320

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG F 401

Chain	Residue
F	ASP179
F	HOH501
G	HOH501
G	HOH502
G	HOH503

site_id	DC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 402

Chain	Residue
F	GLU88
F	ASP89
F	HOH505
F	HOH506
F	HOH507
I	ASP253

site_id	DC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL F 403

Chain	Residue
F	ILE160
F	TYR168
G	PRO14

site_id	EC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG G 401

Chain	Residue
G	ASP277

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 403

Chain	Residue
F	ASP253
G	ASP89
G	HOH504
G	HOH505
G	HOH506

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 404

Chain	Residue
G	HOH507
G	HOH508
G	HOH509
G	HOH510
H	HOH501

site_id	EC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG G 405

Chain	Residue
G	ASP253
G	HOH511
H	ASP89
H	HOH502
H	HOH503

site_id	EC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL G 406

Chain	Residue
G	ILE160
G	ILE161
G	TYR168
G	HOH533
H	PRO14

site_id	EC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 407

Chain	Residue
G	LYS9
G	GLU88
G	ASN92

site_id	EC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG G 408

Chain	Residue
G	PHE306
H	LEU304
H	LEU331

site_id	EC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG G 409

Chain	Residue
G	GLN74
G	HOH535

site_id	EC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG G 411

Chain	Residue
G	GLU246

site_id	FC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG G 412

Chain	Residue
G	GLU121
G	GLN213

site_id	FC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL H 401

Chain	Residue
H	ARG153
H	ILE160
H	TYR168
J	PRO14

site_id	FC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG H 402

Chain	Residue
H	ASP256

site_id	FC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG I 401

Chain	Residue
F	HOH502
F	HOH503
F	HOH504
I	ASP175
I	ASP179
I	HOH501
I	HOH502

site_id	FC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG I 402

Chain	Residue
I	HOH503
I	HOH504
J	HOH508
J	HOH509
J	HOH510
J	HOH511

site_id	FC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG I 403

Chain	Residue
I	ASP89
I	HOH505
I	HOH506
I	HOH507
J	ASP253
J	HOH512

site_id	FC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG I 404

Chain	Residue
I	GLN74

site_id	FC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG J 401

Chain	Residue
H	GLY312
J	GLY312
J	ASN314

site_id	FC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG J 402

Chain	Residue
H	HOH504
H	HOH505
J	HOH501
J	HOH502
J	HOH503

site_id	GC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG J 403

Chain	Residue
H	ASP253
J	ASP89
J	HOH504
J	HOH505
J	HOH506
J	HOH507

site_id	GC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL J 404

Chain	Residue
I	PRO14
J	ILE160
J	ILE161
J	TYR168

site_id	GC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG J 405

Chain	Residue
I	LYS10
J	ASP180
J	VAL183
J	HOH514

site_id	GC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG J 406

Chain	Residue
J	ASP270

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	400
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23112165","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23425532","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26871634","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	100
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	470
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Motif: {"description":"Probable selectivity filter","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23781956","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	10
Details	Site: {"description":"Essential for ion permeation","evidences":[{"source":"PubMed","id":"23091000","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	10
Details	Site: {"description":"Important for closing the ion permeation pathway in the closed state","evidences":[{"source":"PubMed","id":"16598263","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16857941","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16902408","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18276588","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	10
Details	Site: {"description":"Threonine that confers selectivity for Co(2+) transport","evidences":[{"source":"PubMed","id":"23425532","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)