4HTF
Crystal structure of S-adenosylmethionine-dependent methyltransferase from Escherichia coli in complex with S-adenosylmethionine.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| A | 0006400 | biological_process | tRNA modification |
| A | 0008033 | biological_process | tRNA processing |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0097697 | molecular_function | tRNA (5-carboxymethoxyuridine(34)-5-O)-methyltransferase activity |
| B | 0004712 | molecular_function | protein serine/threonine/tyrosine kinase activity |
| B | 0006400 | biological_process | tRNA modification |
| B | 0008033 | biological_process | tRNA processing |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0032259 | biological_process | methylation |
| B | 0097697 | molecular_function | tRNA (5-carboxymethoxyuridine(34)-5-O)-methyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAM A 301 |
| Chain | Residue |
| A | ARG26 |
| A | GLN103 |
| A | HIS119 |
| A | ALA120 |
| A | HOH416 |
| A | HOH424 |
| A | HOH428 |
| A | HOH489 |
| A | HOH510 |
| A | HOH543 |
| A | GLY52 |
| A | GLY53 |
| A | GLY54 |
| A | ASP73 |
| A | LEU74 |
| A | MSE78 |
| A | ALA101 |
| A | ALA102 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 302 |
| Chain | Residue |
| A | LYS22 |
| A | ARG26 |
| A | ARG209 |
| A | TYR247 |
| A | ACT303 |
| A | HOH526 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 303 |
| Chain | Residue |
| A | TYR150 |
| A | HIS158 |
| A | ARG246 |
| A | SO4302 |
| A | HOH580 |
| A | HOH581 |
| site_id | AC4 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE SAM B 301 |
| Chain | Residue |
| B | ARG26 |
| B | GLY52 |
| B | GLY53 |
| B | GLY54 |
| B | ASP73 |
| B | LEU74 |
| B | SER75 |
| B | MSE78 |
| B | ALA101 |
| B | ALA102 |
| B | GLN103 |
| B | HIS119 |
| B | ALA120 |
| B | HOH471 |
| B | HOH477 |
| B | HOH495 |
| B | HOH516 |
| B | HOH518 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | ARG26 |
| B | ARG209 |
| B | TYR247 |
| B | HOH437 |
| B | HOH486 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE BME B 303 |
| Chain | Residue |
| A | GLY163 |
| A | PHE165 |
| B | GLN220 |
| B | CYS224 |
| B | HOH423 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02057","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"NOV-2012","submissionDatabase":"PDB data bank","title":"Crystal structure of S-adenosylmethionine-dependent methyltransferase from Escherichia coli in complex with S-adenosylmethionine.","authors":["Filippova E.V.","Minasov G.","Shuvalova L.","Kiryukhina O.","Jedrzejczak R.","Joachimiak A.","Anderson W.F."]}},{"source":"PDB","id":"4HTF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
