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4HRE

Crystal Structure of p11/Annexin A2 Heterotetramer in Complex with SMARCA3 Peptide

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001533cellular_componentcornified envelope
A0001765biological_processmembrane raft assembly
A0001786molecular_functionphosphatidylserine binding
A0001921biological_processpositive regulation of receptor recycling
A0002020molecular_functionprotease binding
A0002091biological_processnegative regulation of receptor internalization
A0004859molecular_functionphospholipase inhibitor activity
A0004867molecular_functionserine-type endopeptidase inhibitor activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005544molecular_functioncalcium-dependent phospholipid binding
A0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
A0005576cellular_componentextracellular region
A0005604cellular_componentbasement membrane
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005765cellular_componentlysosomal membrane
A0005768cellular_componentendosome
A0005769cellular_componentearly endosome
A0005811cellular_componentlipid droplet
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006900biological_processvesicle budding from membrane
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0008092molecular_functioncytoskeletal protein binding
A0009986cellular_componentcell surface
A0010756biological_processpositive regulation of plasminogen activation
A0012506cellular_componentvesicle membrane
A0014823biological_processresponse to activity
A0016020cellular_componentmembrane
A0016323cellular_componentbasolateral plasma membrane
A0016363cellular_componentnuclear matrix
A0019834molecular_functionphospholipase A2 inhibitor activity
A0030199biological_processcollagen fibril organization
A0030324biological_processlung development
A0030496cellular_componentmidbody
A0031012cellular_componentextracellular matrix
A0031340biological_processpositive regulation of vesicle fusion
A0031902cellular_componentlate endosome membrane
A0032804biological_processnegative regulation of low-density lipoprotein particle receptor catabolic process
A0035749cellular_componentmyelin sheath adaxonal region
A0036035biological_processosteoclast development
A0042383cellular_componentsarcolemma
A0042470cellular_componentmelanosome
A0042730biological_processfibrinolysis
A0042789biological_processmRNA transcription by RNA polymerase II
A0042802molecular_functionidentical protein binding
A0043220cellular_componentSchmidt-Lanterman incisure
A0044090biological_processpositive regulation of vacuole organization
A0044548molecular_functionS100 protein binding
A0045121cellular_componentmembrane raft
A0045921biological_processpositive regulation of exocytosis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048306molecular_functioncalcium-dependent protein binding
A0050767biological_processregulation of neurogenesis
A0070062cellular_componentextracellular exosome
A0090575cellular_componentRNA polymerase II transcription regulator complex
A0098797cellular_componentplasma membrane protein complex
A1904019biological_processepithelial cell apoptotic process
A1905581biological_processpositive regulation of low-density lipoprotein particle clearance
A1905602biological_processpositive regulation of receptor-mediated endocytosis involved in cholesterol transport
A1905686biological_processpositive regulation of plasma membrane repair
A1990665cellular_componentAnxA2-p11 complex
A1990667cellular_componentPCSK9-AnxA2 complex
B0001525biological_processangiogenesis
B0001533cellular_componentcornified envelope
B0001765biological_processmembrane raft assembly
B0001786molecular_functionphosphatidylserine binding
B0001921biological_processpositive regulation of receptor recycling
B0002020molecular_functionprotease binding
B0002091biological_processnegative regulation of receptor internalization
B0004859molecular_functionphospholipase inhibitor activity
B0004867molecular_functionserine-type endopeptidase inhibitor activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005544molecular_functioncalcium-dependent phospholipid binding
B0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
B0005576cellular_componentextracellular region
B0005604cellular_componentbasement membrane
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005765cellular_componentlysosomal membrane
B0005768cellular_componentendosome
B0005769cellular_componentearly endosome
B0005811cellular_componentlipid droplet
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006900biological_processvesicle budding from membrane
B0007155biological_processcell adhesion
B0007160biological_processcell-matrix adhesion
B0008092molecular_functioncytoskeletal protein binding
B0009986cellular_componentcell surface
B0010756biological_processpositive regulation of plasminogen activation
B0012506cellular_componentvesicle membrane
B0014823biological_processresponse to activity
B0016020cellular_componentmembrane
B0016323cellular_componentbasolateral plasma membrane
B0016363cellular_componentnuclear matrix
B0019834molecular_functionphospholipase A2 inhibitor activity
B0030199biological_processcollagen fibril organization
B0030324biological_processlung development
B0030496cellular_componentmidbody
B0031012cellular_componentextracellular matrix
B0031340biological_processpositive regulation of vesicle fusion
B0031902cellular_componentlate endosome membrane
B0032804biological_processnegative regulation of low-density lipoprotein particle receptor catabolic process
B0035749cellular_componentmyelin sheath adaxonal region
B0036035biological_processosteoclast development
B0042383cellular_componentsarcolemma
B0042470cellular_componentmelanosome
B0042730biological_processfibrinolysis
B0042789biological_processmRNA transcription by RNA polymerase II
B0042802molecular_functionidentical protein binding
B0043220cellular_componentSchmidt-Lanterman incisure
B0044090biological_processpositive regulation of vacuole organization
B0044548molecular_functionS100 protein binding
B0045121cellular_componentmembrane raft
B0045921biological_processpositive regulation of exocytosis
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048306molecular_functioncalcium-dependent protein binding
B0050767biological_processregulation of neurogenesis
B0070062cellular_componentextracellular exosome
B0090575cellular_componentRNA polymerase II transcription regulator complex
B0098797cellular_componentplasma membrane protein complex
B1904019biological_processepithelial cell apoptotic process
B1905581biological_processpositive regulation of low-density lipoprotein particle clearance
B1905602biological_processpositive regulation of receptor-mediated endocytosis involved in cholesterol transport
B1905686biological_processpositive regulation of plasma membrane repair
B1990665cellular_componentAnxA2-p11 complex
B1990667cellular_componentPCSK9-AnxA2 complex
C0001525biological_processangiogenesis
C0001533cellular_componentcornified envelope
C0001765biological_processmembrane raft assembly
C0001786molecular_functionphosphatidylserine binding
C0001921biological_processpositive regulation of receptor recycling
C0002020molecular_functionprotease binding
C0002091biological_processnegative regulation of receptor internalization
C0004859molecular_functionphospholipase inhibitor activity
C0004867molecular_functionserine-type endopeptidase inhibitor activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005544molecular_functioncalcium-dependent phospholipid binding
C0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
C0005576cellular_componentextracellular region
C0005604cellular_componentbasement membrane
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005765cellular_componentlysosomal membrane
C0005768cellular_componentendosome
C0005769cellular_componentearly endosome
C0005811cellular_componentlipid droplet
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0006900biological_processvesicle budding from membrane
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0008092molecular_functioncytoskeletal protein binding
C0009986cellular_componentcell surface
C0010756biological_processpositive regulation of plasminogen activation
C0012506cellular_componentvesicle membrane
C0014823biological_processresponse to activity
C0016020cellular_componentmembrane
C0016323cellular_componentbasolateral plasma membrane
C0016363cellular_componentnuclear matrix
C0019834molecular_functionphospholipase A2 inhibitor activity
C0030199biological_processcollagen fibril organization
C0030324biological_processlung development
C0030496cellular_componentmidbody
C0031012cellular_componentextracellular matrix
C0031340biological_processpositive regulation of vesicle fusion
C0031902cellular_componentlate endosome membrane
C0032804biological_processnegative regulation of low-density lipoprotein particle receptor catabolic process
C0035749cellular_componentmyelin sheath adaxonal region
C0036035biological_processosteoclast development
C0042383cellular_componentsarcolemma
C0042470cellular_componentmelanosome
C0042730biological_processfibrinolysis
C0042789biological_processmRNA transcription by RNA polymerase II
C0042802molecular_functionidentical protein binding
C0043220cellular_componentSchmidt-Lanterman incisure
C0044090biological_processpositive regulation of vacuole organization
C0044548molecular_functionS100 protein binding
C0045121cellular_componentmembrane raft
C0045921biological_processpositive regulation of exocytosis
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0048306molecular_functioncalcium-dependent protein binding
C0050767biological_processregulation of neurogenesis
C0070062cellular_componentextracellular exosome
C0090575cellular_componentRNA polymerase II transcription regulator complex
C0098797cellular_componentplasma membrane protein complex
C1904019biological_processepithelial cell apoptotic process
C1905581biological_processpositive regulation of low-density lipoprotein particle clearance
C1905602biological_processpositive regulation of receptor-mediated endocytosis involved in cholesterol transport
C1905686biological_processpositive regulation of plasma membrane repair
C1990665cellular_componentAnxA2-p11 complex
C1990667cellular_componentPCSK9-AnxA2 complex
D0001525biological_processangiogenesis
D0001533cellular_componentcornified envelope
D0001765biological_processmembrane raft assembly
D0001786molecular_functionphosphatidylserine binding
D0001921biological_processpositive regulation of receptor recycling
D0002020molecular_functionprotease binding
D0002091biological_processnegative regulation of receptor internalization
D0004859molecular_functionphospholipase inhibitor activity
D0004867molecular_functionserine-type endopeptidase inhibitor activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005544molecular_functioncalcium-dependent phospholipid binding
D0005546molecular_functionphosphatidylinositol-4,5-bisphosphate binding
D0005576cellular_componentextracellular region
D0005604cellular_componentbasement membrane
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005765cellular_componentlysosomal membrane
D0005768cellular_componentendosome
D0005769cellular_componentearly endosome
D0005811cellular_componentlipid droplet
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0006900biological_processvesicle budding from membrane
D0007155biological_processcell adhesion
D0007160biological_processcell-matrix adhesion
D0008092molecular_functioncytoskeletal protein binding
D0009986cellular_componentcell surface
D0010756biological_processpositive regulation of plasminogen activation
D0012506cellular_componentvesicle membrane
D0014823biological_processresponse to activity
D0016020cellular_componentmembrane
D0016323cellular_componentbasolateral plasma membrane
D0016363cellular_componentnuclear matrix
D0019834molecular_functionphospholipase A2 inhibitor activity
D0030199biological_processcollagen fibril organization
D0030324biological_processlung development
D0030496cellular_componentmidbody
D0031012cellular_componentextracellular matrix
D0031340biological_processpositive regulation of vesicle fusion
D0031902cellular_componentlate endosome membrane
D0032804biological_processnegative regulation of low-density lipoprotein particle receptor catabolic process
D0035749cellular_componentmyelin sheath adaxonal region
D0036035biological_processosteoclast development
D0042383cellular_componentsarcolemma
D0042470cellular_componentmelanosome
D0042730biological_processfibrinolysis
D0042789biological_processmRNA transcription by RNA polymerase II
D0042802molecular_functionidentical protein binding
D0043220cellular_componentSchmidt-Lanterman incisure
D0044090biological_processpositive regulation of vacuole organization
D0044548molecular_functionS100 protein binding
D0045121cellular_componentmembrane raft
D0045921biological_processpositive regulation of exocytosis
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0048306molecular_functioncalcium-dependent protein binding
D0050767biological_processregulation of neurogenesis
D0070062cellular_componentextracellular exosome
D0090575cellular_componentRNA polymerase II transcription regulator complex
D0098797cellular_componentplasma membrane protein complex
D1904019biological_processepithelial cell apoptotic process
D1905581biological_processpositive regulation of low-density lipoprotein particle clearance
D1905602biological_processpositive regulation of receptor-mediated endocytosis involved in cholesterol transport
D1905686biological_processpositive regulation of plasma membrane repair
D1990665cellular_componentAnxA2-p11 complex
D1990667cellular_componentPCSK9-AnxA2 complex
E0001765biological_processmembrane raft assembly
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005737cellular_componentcytoplasm
E0005886cellular_componentplasma membrane
E0006900biological_processvesicle budding from membrane
E0008289molecular_functionlipid binding
E0009986cellular_componentcell surface
E0010756biological_processpositive regulation of plasminogen activation
E0016363cellular_componentnuclear matrix
E0031012cellular_componentextracellular matrix
E0042789biological_processmRNA transcription by RNA polymerase II
E0042803molecular_functionprotein homodimerization activity
E0043547biological_processpositive regulation of GTPase activity
E0044325molecular_functiontransmembrane transporter binding
E0045121cellular_componentmembrane raft
E0045921biological_processpositive regulation of exocytosis
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0048306molecular_functioncalcium-dependent protein binding
E0050767biological_processregulation of neurogenesis
E0051496biological_processpositive regulation of stress fiber assembly
E0051894biological_processpositive regulation of focal adhesion assembly
E0070062cellular_componentextracellular exosome
E0072659biological_processprotein localization to plasma membrane
E0090575cellular_componentRNA polymerase II transcription regulator complex
E0098797cellular_componentplasma membrane protein complex
E1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
E1905686biological_processpositive regulation of plasma membrane repair
E1990665cellular_componentAnxA2-p11 complex
F0001765biological_processmembrane raft assembly
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005737cellular_componentcytoplasm
F0005886cellular_componentplasma membrane
F0006900biological_processvesicle budding from membrane
F0008289molecular_functionlipid binding
F0009986cellular_componentcell surface
F0010756biological_processpositive regulation of plasminogen activation
F0016363cellular_componentnuclear matrix
F0031012cellular_componentextracellular matrix
F0042789biological_processmRNA transcription by RNA polymerase II
F0042803molecular_functionprotein homodimerization activity
F0043547biological_processpositive regulation of GTPase activity
F0044325molecular_functiontransmembrane transporter binding
F0045121cellular_componentmembrane raft
F0045921biological_processpositive regulation of exocytosis
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0048306molecular_functioncalcium-dependent protein binding
F0050767biological_processregulation of neurogenesis
F0051496biological_processpositive regulation of stress fiber assembly
F0051894biological_processpositive regulation of focal adhesion assembly
F0070062cellular_componentextracellular exosome
F0072659biological_processprotein localization to plasma membrane
F0090575cellular_componentRNA polymerase II transcription regulator complex
F0098797cellular_componentplasma membrane protein complex
F1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
F1905686biological_processpositive regulation of plasma membrane repair
F1990665cellular_componentAnxA2-p11 complex
I0001765biological_processmembrane raft assembly
I0005509molecular_functioncalcium ion binding
I0005515molecular_functionprotein binding
I0005576cellular_componentextracellular region
I0005737cellular_componentcytoplasm
I0005886cellular_componentplasma membrane
I0006900biological_processvesicle budding from membrane
I0008289molecular_functionlipid binding
I0009986cellular_componentcell surface
I0010756biological_processpositive regulation of plasminogen activation
I0016363cellular_componentnuclear matrix
I0031012cellular_componentextracellular matrix
I0042789biological_processmRNA transcription by RNA polymerase II
I0042803molecular_functionprotein homodimerization activity
I0043547biological_processpositive regulation of GTPase activity
I0044325molecular_functiontransmembrane transporter binding
I0045121cellular_componentmembrane raft
I0045921biological_processpositive regulation of exocytosis
I0045944biological_processpositive regulation of transcription by RNA polymerase II
I0048306molecular_functioncalcium-dependent protein binding
I0050767biological_processregulation of neurogenesis
I0051496biological_processpositive regulation of stress fiber assembly
I0051894biological_processpositive regulation of focal adhesion assembly
I0070062cellular_componentextracellular exosome
I0072659biological_processprotein localization to plasma membrane
I0090575cellular_componentRNA polymerase II transcription regulator complex
I0098797cellular_componentplasma membrane protein complex
I1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
I1905686biological_processpositive regulation of plasma membrane repair
I1990665cellular_componentAnxA2-p11 complex
J0001765biological_processmembrane raft assembly
J0005509molecular_functioncalcium ion binding
J0005515molecular_functionprotein binding
J0005576cellular_componentextracellular region
J0005737cellular_componentcytoplasm
J0005886cellular_componentplasma membrane
J0006900biological_processvesicle budding from membrane
J0008289molecular_functionlipid binding
J0009986cellular_componentcell surface
J0010756biological_processpositive regulation of plasminogen activation
J0016363cellular_componentnuclear matrix
J0031012cellular_componentextracellular matrix
J0042789biological_processmRNA transcription by RNA polymerase II
J0042803molecular_functionprotein homodimerization activity
J0043547biological_processpositive regulation of GTPase activity
J0044325molecular_functiontransmembrane transporter binding
J0045121cellular_componentmembrane raft
J0045921biological_processpositive regulation of exocytosis
J0045944biological_processpositive regulation of transcription by RNA polymerase II
J0048306molecular_functioncalcium-dependent protein binding
J0050767biological_processregulation of neurogenesis
J0051496biological_processpositive regulation of stress fiber assembly
J0051894biological_processpositive regulation of focal adhesion assembly
J0070062cellular_componentextracellular exosome
J0072659biological_processprotein localization to plasma membrane
J0090575cellular_componentRNA polymerase II transcription regulator complex
J0098797cellular_componentplasma membrane protein complex
J1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
J1905686biological_processpositive regulation of plasma membrane repair
J1990665cellular_componentAnxA2-p11 complex
Functional Information from PROSITE/UniProt
site_idPS00223
Number of Residues53
DetailsANNEXIN_1 Annexin repeat signature. GVdevtivniLtnRsnvQrqDiafaYqrrtkkeLpsaLksalsGhletvIlgL
ChainResidueDetails
AGLY50-LEU102
AGLY122-LEU174
AGLY207-LEU259
AGLY282-LEU334

site_idPS00303
Number of Residues22
DetailsS100_CABP S-100/ICaBP type calcium binding protein signature. IMkdLDqcrDgkvGFqSFfsLI
ChainResidueDetails
EILE54-ILE75

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues284
DetailsRepeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues284
DetailsRepeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues288
DetailsRepeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues284
DetailsRepeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues88
DetailsRegion: {"description":"S100A10-binding site","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues4
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"UniProtKB","id":"P04272","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"UniProtKB","id":"P07355","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"UniProtKB","id":"P07355","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues8
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI11
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07355","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI12
Number of Residues4
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19144319","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI13
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"UniProtKB","id":"P07355","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI14
Number of Residues44
DetailsRegion: {"description":"Ancestral calcium site"}
ChainResidueDetails

site_idSWS_FT_FI15
Number of Residues16
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI16
Number of Residues4
DetailsModified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI17
Number of Residues8
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239803

PDB entries from 2025-08-06

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