4HKC
14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0003723 | molecular_function | RNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007165 | biological_process | signal transduction |
| A | 0008104 | biological_process | intracellular protein localization |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0019903 | molecular_function | protein phosphatase binding |
| A | 0019904 | molecular_function | protein domain specific binding |
| A | 0031625 | molecular_function | ubiquitin protein ligase binding |
| A | 0031647 | biological_process | regulation of protein stability |
| A | 0031982 | cellular_component | vesicle |
| A | 0042149 | biological_process | cellular response to glucose starvation |
| A | 0042470 | cellular_component | melanosome |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0045296 | molecular_function | cadherin binding |
| A | 0045824 | biological_process | negative regulation of innate immune response |
| A | 0050815 | molecular_function | phosphoserine residue binding |
| A | 0051683 | biological_process | establishment of Golgi localization |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0070372 | biological_process | regulation of ERK1 and ERK2 cascade |
| A | 0072562 | cellular_component | blood microparticle |
| A | 0090128 | biological_process | regulation of synapse maturation |
| A | 0090168 | biological_process | Golgi reassembly |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 0140297 | molecular_function | DNA-binding transcription factor binding |
| A | 0140311 | molecular_function | protein sequestering activity |
| A | 1900181 | biological_process | negative regulation of protein localization to nucleus |
| A | 1904262 | biological_process | negative regulation of TORC1 signaling |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 301 |
| Chain | Residue |
| A | LEU203 |
| A | ASP204 |
| A | LEU206 |
| A | HOH501 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Site: {"description":"Interaction with phosphoserine on interacting protein","evidences":[{"source":"UniProtKB","id":"P63103","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA and PKB/AKT1","evidences":[{"source":"PubMed","id":"11956222","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12865427","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15883165","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16376338","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by MAPK8","evidences":[{"source":"PubMed","id":"15071501","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15696159","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P63102","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
