4HI9

1.2 structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at wavelength 0.91974

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 A 201

Chain	Residue
A	ARG43
A	SER76
A	HIS77
A	HOH314
A	HOH317
B	GLN40
B	ARG56
B	TYR58
B	HOH205

---

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 202

Chain	Residue
A	GLN114

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 203

Chain	Residue
A	HOH381

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 204

Chain	Residue
A	THR167
B	IOD104

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 205

Chain	Residue
A	TRP110
A	HOH402

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 207

Chain	Residue
A	SER47
A	ASP81
A	HOH445

---

site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 208

Chain	Residue
A	ASP81

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD A 209

Chain	Residue
A	HOH365
A	HOH366

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 101

Chain	Residue
B	CYS10
B	CYS13
B	HIS32
B	CYS35

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 102

Chain	Residue
B	CYS38
B	CYS41
B	CYS59
B	ASP62

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B 103

Chain	Residue
B	LYS57

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD B 104

Chain	Residue
A	PHE168
A	IOD204

---

Functional Information from PROSITE/UniProt

site_id	PS00478
Number of Residues	36
Details	LIM_DOMAIN_1 LIM zinc-binding domain signature. CerCkggfapaekivnsngel....YHeqCfvCaqCfqqF

Chain	Residue	Details
B	CYS10-PHE45

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	Repeat: {"description":"ANK 2","evidences":[{"source":"PubMed","id":"19074270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	32
Details	Repeat: {"description":"ANK 3","evidences":[{"source":"PubMed","id":"19074270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Repeat: {"description":"ANK 4","evidences":[{"source":"PubMed","id":"19074270","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	106
Details	Region: {"description":"Interaction with LIMS1","evidences":[{"source":"PubMed","id":"12167643","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	52
Details	Domain: {"description":"LIM zinc-binding 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00125","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---