4HFH
The GLIC pentameric Ligand-Gated Ion Channel (wild-type) complexed to bromoform
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004888 | molecular_function | transmembrane signaling receptor activity |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
A | 0005267 | molecular_function | potassium channel activity |
A | 0005272 | molecular_function | sodium channel activity |
A | 0005886 | cellular_component | plasma membrane |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0006814 | biological_process | sodium ion transport |
A | 0016020 | cellular_component | membrane |
A | 0034220 | biological_process | monoatomic ion transmembrane transport |
A | 0035725 | biological_process | sodium ion transmembrane transport |
A | 0042802 | molecular_function | identical protein binding |
A | 0071805 | biological_process | potassium ion transmembrane transport |
A | 1902495 | cellular_component | transmembrane transporter complex |
B | 0004888 | molecular_function | transmembrane signaling receptor activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
B | 0005267 | molecular_function | potassium channel activity |
B | 0005272 | molecular_function | sodium channel activity |
B | 0005886 | cellular_component | plasma membrane |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0006814 | biological_process | sodium ion transport |
B | 0016020 | cellular_component | membrane |
B | 0034220 | biological_process | monoatomic ion transmembrane transport |
B | 0035725 | biological_process | sodium ion transmembrane transport |
B | 0042802 | molecular_function | identical protein binding |
B | 0071805 | biological_process | potassium ion transmembrane transport |
B | 1902495 | cellular_component | transmembrane transporter complex |
C | 0004888 | molecular_function | transmembrane signaling receptor activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
C | 0005267 | molecular_function | potassium channel activity |
C | 0005272 | molecular_function | sodium channel activity |
C | 0005886 | cellular_component | plasma membrane |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0006814 | biological_process | sodium ion transport |
C | 0016020 | cellular_component | membrane |
C | 0034220 | biological_process | monoatomic ion transmembrane transport |
C | 0035725 | biological_process | sodium ion transmembrane transport |
C | 0042802 | molecular_function | identical protein binding |
C | 0071805 | biological_process | potassium ion transmembrane transport |
C | 1902495 | cellular_component | transmembrane transporter complex |
D | 0004888 | molecular_function | transmembrane signaling receptor activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
D | 0005267 | molecular_function | potassium channel activity |
D | 0005272 | molecular_function | sodium channel activity |
D | 0005886 | cellular_component | plasma membrane |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0006814 | biological_process | sodium ion transport |
D | 0016020 | cellular_component | membrane |
D | 0034220 | biological_process | monoatomic ion transmembrane transport |
D | 0035725 | biological_process | sodium ion transmembrane transport |
D | 0042802 | molecular_function | identical protein binding |
D | 0071805 | biological_process | potassium ion transmembrane transport |
D | 1902495 | cellular_component | transmembrane transporter complex |
E | 0004888 | molecular_function | transmembrane signaling receptor activity |
E | 0005216 | molecular_function | monoatomic ion channel activity |
E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
E | 0005267 | molecular_function | potassium channel activity |
E | 0005272 | molecular_function | sodium channel activity |
E | 0005886 | cellular_component | plasma membrane |
E | 0006811 | biological_process | monoatomic ion transport |
E | 0006814 | biological_process | sodium ion transport |
E | 0016020 | cellular_component | membrane |
E | 0034220 | biological_process | monoatomic ion transmembrane transport |
E | 0035725 | biological_process | sodium ion transmembrane transport |
E | 0042802 | molecular_function | identical protein binding |
E | 0071805 | biological_process | potassium ion transmembrane transport |
E | 1902495 | cellular_component | transmembrane transporter complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT A 401 |
Chain | Residue |
A | ARG77 |
A | ILE131 |
A | GLU181 |
E | PHE42 |
E | ARG105 |
site_id | AC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PLC A 402 |
Chain | Residue |
A | ASN307 |
A | PLC403 |
A | ARG118 |
A | PHE121 |
A | TYR194 |
A | TYR254 |
site_id | AC3 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE PLC A 403 |
Chain | Residue |
A | PLC402 |
site_id | AC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL A 406 |
Chain | Residue |
A | PHE78 |
A | ARG85 |
site_id | AC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 407 |
Chain | Residue |
A | ASN139 |
A | LEU180 |
D | ALA175 |
site_id | AC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CL A 408 |
Chain | Residue |
A | ALA175 |
D | ASN139 |
D | LEU180 |
site_id | AC7 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA A 409 |
Chain | Residue |
A | PRO68 |
A | ILE71 |
A | ILE73 |
site_id | AC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT A 410 |
Chain | Residue |
A | ILE73 |
A | PRO74 |
A | ILE76 |
A | ARG85 |
A | TYR102 |
site_id | AC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE LMT A 411 |
Chain | Residue |
C | LMT409 |
E | LMT409 |
site_id | BC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE LMT A 412 |
Chain | Residue |
A | ALA237 |
B | THR244 |
site_id | BC2 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MBR A 413 |
Chain | Residue |
A | TYR119 |
A | TYR197 |
A | ILE201 |
A | VAL242 |
A | ASN245 |
A | MBR414 |
site_id | BC3 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE MBR A 414 |
Chain | Residue |
A | TYR119 |
A | PRO120 |
A | TYR197 |
A | ILE201 |
A | ILE202 |
A | THR255 |
A | ILE258 |
A | MBR413 |
site_id | BC4 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT B 401 |
Chain | Residue |
A | PHE42 |
A | ARG105 |
B | ARG77 |
B | ILE131 |
B | GLU181 |
site_id | BC5 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PLC B 402 |
Chain | Residue |
B | ARG118 |
B | PHE121 |
B | TYR194 |
B | TYR254 |
B | ASN307 |
B | MBR411 |
site_id | BC6 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL B 406 |
Chain | Residue |
B | PHE78 |
B | ARG85 |
site_id | BC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE NA B 407 |
Chain | Residue |
B | PRO68 |
B | ILE71 |
B | TRP72 |
B | ILE73 |
site_id | BC8 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT B 408 |
Chain | Residue |
B | ILE73 |
B | PRO74 |
B | ILE76 |
B | ARG85 |
B | TYR102 |
site_id | BC9 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE LMT B 409 |
Chain | Residue |
A | ALA237 |
B | ALA237 |
site_id | CC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MBR B 410 |
Chain | Residue |
B | TYR119 |
B | TYR197 |
B | ILE201 |
B | LEU241 |
B | ASN245 |
B | MBR411 |
C | LYS248 |
site_id | CC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE MBR B 411 |
Chain | Residue |
B | TYR119 |
B | PRO120 |
B | TYR197 |
B | ILE201 |
B | ILE202 |
B | THR255 |
B | ILE258 |
B | ILE259 |
B | PLC402 |
B | MBR410 |
site_id | CC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT C 401 |
Chain | Residue |
B | PHE42 |
B | ARG105 |
C | ARG77 |
C | ILE131 |
C | GLU181 |
site_id | CC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PLC C 402 |
Chain | Residue |
C | ARG118 |
C | PHE121 |
C | TYR194 |
C | TYR254 |
C | ASN307 |
C | MBR411 |
site_id | CC5 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL C 406 |
Chain | Residue |
C | ARG85 |
C | PHE78 |
site_id | CC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA C 407 |
Chain | Residue |
C | PRO68 |
C | ILE71 |
C | ILE73 |
site_id | CC7 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE ACT C 408 |
Chain | Residue |
C | ILE73 |
C | PRO74 |
C | ILE76 |
C | ARG85 |
C | TYR102 |
C | HOH537 |
site_id | CC8 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE LMT C 409 |
Chain | Residue |
A | LMT411 |
site_id | CC9 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MBR C 410 |
Chain | Residue |
C | TYR119 |
C | TYR197 |
C | ILE201 |
C | LEU241 |
C | ASN245 |
C | MBR411 |
D | LYS248 |
site_id | DC1 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE MBR C 411 |
Chain | Residue |
C | TYR119 |
C | PRO120 |
C | TYR197 |
C | ILE201 |
C | ILE202 |
C | THR255 |
C | ILE258 |
C | ILE259 |
C | PLC402 |
C | MBR410 |
site_id | DC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT D 401 |
Chain | Residue |
C | PHE42 |
C | ARG105 |
D | ARG77 |
D | ILE131 |
D | GLU181 |
site_id | DC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE PLC D 402 |
Chain | Residue |
D | ARG118 |
D | PHE121 |
D | TYR194 |
D | TYR254 |
D | ASN307 |
D | MBR411 |
site_id | DC4 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL D 406 |
Chain | Residue |
D | PHE78 |
D | ARG85 |
site_id | DC5 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA D 407 |
Chain | Residue |
D | VAL5 |
D | ILE71 |
D | ILE73 |
site_id | DC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT D 408 |
Chain | Residue |
D | ILE73 |
D | PRO74 |
D | ILE76 |
D | ARG85 |
D | TYR102 |
site_id | DC7 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE LMT D 409 |
Chain | Residue |
D | ILE233 |
D | ALA237 |
site_id | DC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MBR D 410 |
Chain | Residue |
D | TYR119 |
D | TYR197 |
D | ILE201 |
D | VAL242 |
D | ASN245 |
D | MBR411 |
site_id | DC9 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE MBR D 411 |
Chain | Residue |
D | ILE202 |
D | MET205 |
D | THR255 |
D | ILE258 |
D | PLC402 |
D | MBR410 |
site_id | EC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ACT E 401 |
Chain | Residue |
D | PHE42 |
D | ARG105 |
E | ARG77 |
E | ILE131 |
E | GLU181 |
site_id | EC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE PLC E 402 |
Chain | Residue |
E | ARG118 |
E | PHE121 |
E | TYR194 |
E | TYR254 |
site_id | EC3 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE CL E 406 |
Chain | Residue |
E | PHE78 |
E | ARG85 |
site_id | EC4 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE NA E 407 |
Chain | Residue |
E | PRO68 |
E | ILE71 |
E | ILE73 |
site_id | EC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ACT E 408 |
Chain | Residue |
E | PRO74 |
E | ILE76 |
E | ARG85 |
E | TYR102 |
site_id | EC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE LMT E 409 |
Chain | Residue |
A | LMT411 |
D | ALA237 |
E | ILE240 |
site_id | EC7 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE MBR E 410 |
Chain | Residue |
A | LYS248 |
E | TYR119 |
E | TYR197 |
E | ILE201 |
E | VAL242 |
E | ASN245 |
E | MBR411 |
site_id | EC8 |
Number of Residues | 8 |
Details | BINDING SITE FOR RESIDUE MBR E 411 |
Chain | Residue |
E | TYR119 |
E | PRO120 |
E | TYR197 |
E | ILE201 |
E | ILE202 |
E | THR255 |
E | ILE258 |
E | MBR410 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 990 |
Details | TOPO_DOM: Periplasmic => ECO:0000255 |
Chain | Residue | Details |
A | GLN2-GLN193 | |
E | ASN245-MET252 | |
A | ASN245-MET252 | |
B | GLN2-GLN193 | |
B | ASN245-MET252 | |
C | GLN2-GLN193 | |
C | ASN245-MET252 | |
D | GLN2-GLN193 | |
D | ASN245-MET252 | |
E | GLN2-GLN193 |
site_id | SWS_FT_FI2 |
Number of Residues | 530 |
Details | TRANSMEM: Helical |
Chain | Residue | Details |
A | TYR194-PHE216 | |
C | SER220-THR244 | |
C | THR253-VAL281 | |
C | PRO285-PHE317 | |
D | TYR194-PHE216 | |
D | SER220-THR244 | |
D | THR253-VAL281 | |
D | PRO285-PHE317 | |
E | TYR194-PHE216 | |
E | SER220-THR244 | |
E | THR253-VAL281 | |
A | SER220-THR244 | |
E | PRO285-PHE317 | |
A | THR253-VAL281 | |
A | PRO285-PHE317 | |
B | TYR194-PHE216 | |
B | SER220-THR244 | |
B | THR253-VAL281 | |
B | PRO285-PHE317 | |
C | TYR194-PHE216 |
site_id | SWS_FT_FI3 |
Number of Residues | 20 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
Chain | Residue | Details |
A | TRP217-THR219 | |
E | GLU282-GLN284 | |
A | GLU282-GLN284 | |
B | TRP217-THR219 | |
B | GLU282-GLN284 | |
C | TRP217-THR219 | |
C | GLU282-GLN284 | |
D | TRP217-THR219 | |
D | GLU282-GLN284 | |
E | TRP217-THR219 |