Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4HFB

The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005267	molecular_function	potassium channel activity
A	0005272	molecular_function	sodium channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0035725	biological_process	sodium ion transmembrane transport
A	0042802	molecular_function	identical protein binding
A	0071805	biological_process	potassium ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005267	molecular_function	potassium channel activity
B	0005272	molecular_function	sodium channel activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006813	biological_process	potassium ion transport
B	0006814	biological_process	sodium ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0035725	biological_process	sodium ion transmembrane transport
B	0042802	molecular_function	identical protein binding
B	0071805	biological_process	potassium ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005267	molecular_function	potassium channel activity
C	0005272	molecular_function	sodium channel activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0006814	biological_process	sodium ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0035725	biological_process	sodium ion transmembrane transport
C	0042802	molecular_function	identical protein binding
C	0071805	biological_process	potassium ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005267	molecular_function	potassium channel activity
D	0005272	molecular_function	sodium channel activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006813	biological_process	potassium ion transport
D	0006814	biological_process	sodium ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0035725	biological_process	sodium ion transmembrane transport
D	0042802	molecular_function	identical protein binding
D	0071805	biological_process	potassium ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005267	molecular_function	potassium channel activity
E	0005272	molecular_function	sodium channel activity
E	0005886	cellular_component	plasma membrane
E	0006811	biological_process	monoatomic ion transport
E	0006813	biological_process	potassium ion transport
E	0006814	biological_process	sodium ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0035725	biological_process	sodium ion transmembrane transport
E	0042802	molecular_function	identical protein binding
E	0071805	biological_process	potassium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 401

Chain	Residue
A	ILE73
A	PRO74
A	ILE76
A	ARG85
A	TYR102

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 402

Chain	Residue
A	PHE78
A	ARG85
A	HOH502

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT A 403

Chain	Residue
A	ILE131
A	GLU181
E	PHE42
E	ARG105
A	ARG77

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA A 404

Chain	Residue
A	PRO68
A	ILE71
A	ILE73

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PLC A 405

Chain	Residue
A	ARG118
A	PHE121
A	TYR194
A	TYR254
A	ASN307
A	PHE315

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 401

Chain	Residue
B	ILE73
B	PRO74
B	ILE76
B	ARG85
B	TYR102

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL B 402

Chain	Residue
B	PHE78
B	ARG85

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 403

Chain	Residue
A	PHE42
A	ARG105
B	ARG77
B	ILE131
B	GLU181

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA B 404

Chain	Residue
B	ILE71
B	TRP72
B	ILE73

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PLC B 405

Chain	Residue
B	ARG118
B	PHE121
B	TYR194
B	TYR254

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 401

Chain	Residue
C	ILE73
C	PRO74
C	GLU75
C	ILE76
C	ARG85

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 402

Chain	Residue
C	PHE78
C	ARG85

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT C 403

Chain	Residue
B	PHE42
B	ARG105
C	ARG77
C	ILE131
C	GLU181

site_id	BC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA C 404

Chain	Residue
C	PRO68
C	ILE71

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PLC C 405

Chain	Residue
C	ARG118
C	TYR254
C	PHE315

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT D 401

Chain	Residue
D	ILE73
D	PRO74
D	GLU75
D	ILE76
D	ARG85

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 402

Chain	Residue
D	PHE78
D	ARG85

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT D 403

Chain	Residue
C	PHE42
C	ARG105
D	ARG77
D	ILE131
D	GLU181

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE NA D 404

Chain	Residue
D	PRO68
D	ILE71
D	ILE73

site_id	CC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC D 405

Chain	Residue
D	ARG118
D	PHE121
D	TYR194
D	TYR254
D	PHE315

site_id	CC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT E 401

Chain	Residue
E	PRO74
E	ILE76
E	ARG85
E	TYR102

site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL E 402

Chain	Residue
E	PHE78
E	ARG85

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT E 403

Chain	Residue
D	PHE42
D	ARG105
E	ARG77
E	ILE131
E	GLU181

site_id	CC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NA E 404

Chain	Residue
E	PRO68
E	ILE71

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PLC E 406

Chain	Residue
E	ARG118
E	PHE121
E	TYR254
E	ASN307
E	PHE315

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Transmembrane: {"description":"Helical"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	20
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	35
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)