4HFB
The GLIC pentameric Ligand-Gated Ion Channel F14'A ethanol-sensitive mutant (Apo)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0005267 | molecular_function | potassium channel activity |
| A | 0005272 | molecular_function | sodium channel activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| A | 0035725 | biological_process | sodium ion transmembrane transport |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0071805 | biological_process | potassium ion transmembrane transport |
| A | 1902495 | cellular_component | transmembrane transporter complex |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0005267 | molecular_function | potassium channel activity |
| B | 0005272 | molecular_function | sodium channel activity |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0006814 | biological_process | sodium ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0035725 | biological_process | sodium ion transmembrane transport |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0071805 | biological_process | potassium ion transmembrane transport |
| B | 1902495 | cellular_component | transmembrane transporter complex |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0005267 | molecular_function | potassium channel activity |
| C | 0005272 | molecular_function | sodium channel activity |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0006814 | biological_process | sodium ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0035725 | biological_process | sodium ion transmembrane transport |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0071805 | biological_process | potassium ion transmembrane transport |
| C | 1902495 | cellular_component | transmembrane transporter complex |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0005267 | molecular_function | potassium channel activity |
| D | 0005272 | molecular_function | sodium channel activity |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0006814 | biological_process | sodium ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0035725 | biological_process | sodium ion transmembrane transport |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0071805 | biological_process | potassium ion transmembrane transport |
| D | 1902495 | cellular_component | transmembrane transporter complex |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0005267 | molecular_function | potassium channel activity |
| E | 0005272 | molecular_function | sodium channel activity |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0006814 | biological_process | sodium ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0035725 | biological_process | sodium ion transmembrane transport |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0071805 | biological_process | potassium ion transmembrane transport |
| E | 1902495 | cellular_component | transmembrane transporter complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 401 |
| Chain | Residue |
| A | ILE73 |
| A | PRO74 |
| A | ILE76 |
| A | ARG85 |
| A | TYR102 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CL A 402 |
| Chain | Residue |
| A | PHE78 |
| A | ARG85 |
| A | HOH502 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT A 403 |
| Chain | Residue |
| A | ILE131 |
| A | GLU181 |
| E | PHE42 |
| E | ARG105 |
| A | ARG77 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA A 404 |
| Chain | Residue |
| A | PRO68 |
| A | ILE71 |
| A | ILE73 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PLC A 405 |
| Chain | Residue |
| A | ARG118 |
| A | PHE121 |
| A | TYR194 |
| A | TYR254 |
| A | ASN307 |
| A | PHE315 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 401 |
| Chain | Residue |
| B | ILE73 |
| B | PRO74 |
| B | ILE76 |
| B | ARG85 |
| B | TYR102 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL B 402 |
| Chain | Residue |
| B | PHE78 |
| B | ARG85 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 403 |
| Chain | Residue |
| A | PHE42 |
| A | ARG105 |
| B | ARG77 |
| B | ILE131 |
| B | GLU181 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA B 404 |
| Chain | Residue |
| B | ILE71 |
| B | TRP72 |
| B | ILE73 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PLC B 405 |
| Chain | Residue |
| B | ARG118 |
| B | PHE121 |
| B | TYR194 |
| B | TYR254 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 401 |
| Chain | Residue |
| C | ILE73 |
| C | PRO74 |
| C | GLU75 |
| C | ILE76 |
| C | ARG85 |
| site_id | BC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 402 |
| Chain | Residue |
| C | PHE78 |
| C | ARG85 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT C 403 |
| Chain | Residue |
| B | PHE42 |
| B | ARG105 |
| C | ARG77 |
| C | ILE131 |
| C | GLU181 |
| site_id | BC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA C 404 |
| Chain | Residue |
| C | PRO68 |
| C | ILE71 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PLC C 405 |
| Chain | Residue |
| C | ARG118 |
| C | TYR254 |
| C | PHE315 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D 401 |
| Chain | Residue |
| D | ILE73 |
| D | PRO74 |
| D | GLU75 |
| D | ILE76 |
| D | ARG85 |
| site_id | BC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 402 |
| Chain | Residue |
| D | PHE78 |
| D | ARG85 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D 403 |
| Chain | Residue |
| C | PHE42 |
| C | ARG105 |
| D | ARG77 |
| D | ILE131 |
| D | GLU181 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA D 404 |
| Chain | Residue |
| D | PRO68 |
| D | ILE71 |
| D | ILE73 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PLC D 405 |
| Chain | Residue |
| D | ARG118 |
| D | PHE121 |
| D | TYR194 |
| D | TYR254 |
| D | PHE315 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT E 401 |
| Chain | Residue |
| E | PRO74 |
| E | ILE76 |
| E | ARG85 |
| E | TYR102 |
| site_id | CC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL E 402 |
| Chain | Residue |
| E | PHE78 |
| E | ARG85 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT E 403 |
| Chain | Residue |
| D | PHE42 |
| D | ARG105 |
| E | ARG77 |
| E | ILE131 |
| E | GLU181 |
| site_id | CC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE NA E 404 |
| Chain | Residue |
| E | PRO68 |
| E | ILE71 |
| site_id | CC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PLC E 406 |
| Chain | Residue |
| E | ARG118 |
| E | PHE121 |
| E | TYR254 |
| E | ASN307 |
| E | PHE315 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 990 |
| Details | TOPO_DOM: Periplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | GLN2-GLN193 | |
| E | ASN245-MET252 | |
| A | ASN245-MET252 | |
| B | GLN2-GLN193 | |
| B | ASN245-MET252 | |
| C | GLN2-GLN193 | |
| C | ASN245-MET252 | |
| D | GLN2-GLN193 | |
| D | ASN245-MET252 | |
| E | GLN2-GLN193 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 530 |
| Details | TRANSMEM: Helical |
| Chain | Residue | Details |
| A | TYR194-PHE216 | |
| C | SER220-THR244 | |
| C | THR253-VAL281 | |
| C | PRO285-PHE317 | |
| D | TYR194-PHE216 | |
| D | SER220-THR244 | |
| D | THR253-VAL281 | |
| D | PRO285-PHE317 | |
| E | TYR194-PHE216 | |
| E | SER220-THR244 | |
| E | THR253-VAL281 | |
| A | SER220-THR244 | |
| E | PRO285-PHE317 | |
| A | THR253-VAL281 | |
| A | PRO285-PHE317 | |
| B | TYR194-PHE216 | |
| B | SER220-THR244 | |
| B | THR253-VAL281 | |
| B | PRO285-PHE317 | |
| C | TYR194-PHE216 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | TRP217-THR219 | |
| E | GLU282-GLN284 | |
| A | GLU282-GLN284 | |
| B | TRP217-THR219 | |
| B | GLU282-GLN284 | |
| C | TRP217-THR219 | |
| C | GLU282-GLN284 | |
| D | TRP217-THR219 | |
| D | GLU282-GLN284 | |
| E | TRP217-THR219 |
