4HBG

Crystal structure of Saccharomyces cerevisiae 3 oxoacyl-[acyl carrier protein]-reductase complexed with NADPH (form2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004316	molecular_function	3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
A	0005739	cellular_component	mitochondrion
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0009060	biological_process	aerobic respiration
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0048038	molecular_function	quinone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NDP A 301

Chain	Residue
A	GLY11
A	PHE67
A	LYS68
A	CYS120
A	ALA121
A	GLY122
A	VAL143
A	ILE181
A	SER183
A	TYR198
A	LYS202
A	ALA12
A	PRO228
A	GLY229
A	LEU230
A	HOH404
A	THR13
A	ARG14
A	ILE16
A	SER36
A	SER40
A	ILE65
A	ASP66

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Functional Information from PROSITE/UniProt

site_id	PS00061
Number of Residues	29
Details	ADH_SHORT Short-chain dehydrogenases/reductases family signature. LhsgkmkvpgTsvYSASKAALsRFTeVLA

Chain	Residue	Details
A	LEU185-ALA213

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000250|UniProtKB:O93868

Chain	Residue	Details
A	SER182

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10001

Chain	Residue	Details
A	TYR198

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	ACT_SITE: Lowers pKa of active site Tyr => ECO:0000250|UniProtKB:O93868

Chain	Residue	Details
A	LYS202

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0007744|PDB:4FDA, ECO:0007744|PDB:4HBG

Chain	Residue	Details
A	THR13
A	ARG14
A	SER36
A	SER40
A	ASP66
A	PHE67
A	GLY122
A	TYR198

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	BINDING: BINDING => ECO:0007744|PDB:4HBG

Chain	Residue	Details
A	ILE16
A	LYS202
A	LEU230

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250|UniProtKB:L0E2Z4

Chain	Residue	Details
A	THR44
A	GLU77

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:4FDA

Chain	Residue	Details
A	GLN125
A	GLU126

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O93868

Chain	Residue	Details
A	VAL231

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