4HAK

Multicopper Oxidase CueO mutant E506A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004322	molecular_function	ferroxidase activity
A	0005507	molecular_function	copper ion binding
A	0010273	biological_process	detoxification of copper ion
A	0016491	molecular_function	oxidoreductase activity
A	0016682	molecular_function	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A	0016722	molecular_function	oxidoreductase activity, acting on metal ions
A	0016724	molecular_function	oxidoreductase activity, acting on metal ions, oxygen as acceptor
A	0030288	cellular_component	outer membrane-bounded periplasmic space
A	0042597	cellular_component	periplasmic space
A	0046688	biological_process	response to copper ion
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CU A 1001

Chain	Residue
A	LEU442
A	HIS443
A	CYS500
A	HIS505
A	MET510

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CU A 1002

Chain	Residue
A	HIS103
A	HIS141
A	HIS501
A	OH1005

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CU A 1003

Chain	Residue
A	HIS143
A	HIS446
A	HIS448
A	HIS499
A	CU1004
A	OH1005

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE CU A 1004

Chain	Residue
A	HIS101
A	HIS103
A	HIS446
A	HIS448
A	CU1003
A	OH1005
A	ACT1006
A	HOH1104

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE OH A 1005

Chain	Residue
A	HIS101
A	HIS141
A	HIS143
A	HIS446
A	HIS448
A	HIS499
A	HIS501
A	CU1002
A	CU1003
A	CU1004
A	HOH1101

---

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ACT A 1006

Chain	Residue
A	HIS101
A	TRP102
A	HIS103
A	GLY104
A	LEU105
A	HIS446
A	ILE447
A	HIS448
A	GLY449
A	THR450
A	CU1004
A	HOH1104
A	HOH1105
A	HOH1106

---

Functional Information from PROSITE/UniProt

site_id	PS00080
Number of Residues	12
Details	MULTICOPPER_OXIDASE2 Multicopper oxidases signature 2. HCHlleHadtGM

Chain	Residue	Details
A	HIS499-MET510

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	110
Details	Domain: {"description":"Plastocyanin-like 1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	65
Details	Domain: {"description":"Plastocyanin-like 2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	114
Details	Domain: {"description":"Plastocyanin-like 3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"description":"type 2 copper site","evidences":[{"source":"PubMed","id":"11867755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12794077","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17217912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17804014","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21903583","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24598746","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N68","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PF3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"description":"type 3 copper site","evidences":[{"source":"PubMed","id":"11867755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12794077","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17217912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17804014","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21903583","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24598746","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N68","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PF3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	Binding site: {"description":"type 1 copper site","evidences":[{"source":"PubMed","id":"11867755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12794077","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17217912","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17804014","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21903583","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24598746","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1KV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1N68","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PF3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2FQG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YXW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---