4H3K

Crystal structure of a ternary complex of human symplekin NTD, human Ssu72 and a RNA polymerase II CTD peptide phosphorylated at Ser-2, Ser-5 and Ser-7

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0004721	molecular_function	phosphoprotein phosphatase activity
B	0004722	molecular_function	protein serine/threonine phosphatase activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005847	cellular_component	mRNA cleavage and polyadenylation specificity factor complex
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006369	biological_process	termination of RNA polymerase II transcription
B	0006397	biological_process	mRNA processing
B	0008420	molecular_function	RNA polymerase II CTD heptapeptide repeat phosphatase activity
B	0017018	molecular_function	myosin phosphatase activity
B	0180010	biological_process	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway
E	0004721	molecular_function	phosphoprotein phosphatase activity
E	0004722	molecular_function	protein serine/threonine phosphatase activity
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005847	cellular_component	mRNA cleavage and polyadenylation specificity factor complex
E	0006357	biological_process	regulation of transcription by RNA polymerase II
E	0006369	biological_process	termination of RNA polymerase II transcription
E	0006397	biological_process	mRNA processing
E	0008420	molecular_function	RNA polymerase II CTD heptapeptide repeat phosphatase activity
E	0017018	molecular_function	myosin phosphatase activity
E	0180010	biological_process	co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PO4 B 201

Chain	Residue
B	SER12
B	SER13
B	SER14
B	ASN15
B	GLN16
B	ASN17
B	ARG18
B	ASP143
B	HOH315

---

Functional Information from PROSITE/UniProt

site_id	PS00097
Number of Residues	8
Details	CARBAMOYLTRANSFERASE Aspartate and ornithine carbamoyltransferases signature. FeEkSGRT

Chain	Residue	Details
B	PHE179-THR186

---

site_id	PS00115
Number of Residues	7
Details	RNA_POL_II_REPEAT Eukaryotic RNA polymerase II heptapeptide repeat. YSPTSPS

Chain	Residue	Details
F	TYR1-SEP7

---