4H2N

Crystal structure of MHPCO, Y270F mutant

Replaces:  3ALK

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004497	molecular_function	monooxygenase activity
A	0016491	molecular_function	oxidoreductase activity
A	0047081	molecular_function	3-hydroxy-2-methylpyridinecarboxylate dioxygenase activity
A	0071949	molecular_function	FAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	29
Details	BINDING SITE FOR RESIDUE FAD A 401

Chain	Residue
A	GLY18
A	ARG106
A	SER128
A	GLU129
A	ALA130
A	ALA155
A	ASP156
A	LEU179
A	ARG181
A	GLY287
A	ASP288
A	GLY20
A	ALA298
A	GLY300
A	ALA301
A	GLY302
A	HOH503
A	HOH505
A	HOH515
A	HOH528
A	HOH550
A	HOH553
A	PHE21
A	ALA22
A	HIS40
A	GLU41
A	LYS42
A	ILE53
A	TYR54

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site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BME A 402

Chain	Residue
A	PHE270
A	CYS294

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 403

Chain	Residue
A	LEU73
A	GLN74
A	GLY75
A	SER76
A	ASN97
A	PRO378
A	GLN379

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19317437","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27568368","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ALJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ALL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ALM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GMB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3GMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GF7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2Q","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4JY3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HXI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27568368","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4JY3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19317437","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GMC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4H2Q","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19317437","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3GMC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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