4GZN

Mouse ZFP57 zinc fingers in complex with methylated DNA

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA B 101

Chain	Residue
A	HOH101
A	HOH103
B	HOH203
B	HOH204
B	HOH206
B	HOH208
B	HOH209

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MPD C 201

Chain	Residue
C	ASN184
C	HOH313
C	HOH328
C	HOH329
C	HOH377
A	HOH168
C	PHE141

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MPD C 202

Chain	Residue
B	5CM5
B	HOH265
C	HIS158
C	ALA161
C	ALA161
C	HIS162
C	GLY164
C	HOH333

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 203

Chain	Residue
C	CYS170
C	CYS173
C	HIS186
C	HIS190

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 204

Chain	Residue
C	CYS142
C	CYS145
C	HIS158
C	HIS162

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT C 205

Chain	Residue
A	HOH111
C	LEU163
C	TYR165
C	HIS190
C	HOH337
C	HOH352
C	HOH392

---

Functional Information from PROSITE/UniProt

site_id	PS00028
Number of Residues	21
Details	ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cnf..CgktYrdasglsrHrra..H

Chain	Residue	Details
C	CYS142-HIS162
C	CYS170-HIS190

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	22
Details	Zinc finger: {"description":"C2H2-type 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	22
Details	Zinc finger: {"description":"C2H2-type 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00042","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Crucial for 5-methylcytosine recognition"}

Chain

Residue

Details

---