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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GZ0

Mus Musculus Tdp2-DNA Substrate Analog (5'-6-aminohexanol) Complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity
E	0003824	molecular_function	catalytic activity
G	0003824	molecular_function	catalytic activity
I	0003824	molecular_function	catalytic activity
K	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 401

Chain	Residue
A	GLU333
A	GLY335
A	HIS336
A	LEU337

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 402

Chain	Residue
A	HOH605
A	ASP277
A	TRP294
A	GLN304
A	TYR305
A	ARG324

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 403

Chain	Residue
A	TYR188
A	MET214
A	HOH642
H	EDO102
H	HOH201

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 404

Chain	Residue
A	EDO409
A	HOH527
G	GLU348
G	LYS349

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 405

Chain	Residue
A	PHE209
A	PRO210
A	ASN211
A	THR212
A	GLU246
A	ARG249

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 406

Chain	Residue
A	SER341
A	HOH575
G	SER148

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 407

Chain	Residue
A	CYS149
A	GLU348
A	ACT427
G	TYR153
G	ASP343
G	LEU344

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 408

Chain	Residue
A	THR179
A	LYS196
A	VAL199
A	PHE201
A	HOH593

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 409

Chain	Residue
A	GLN304
A	TYR305
A	ASP308
A	ALA311
A	LEU344
A	TRP360
A	EDO404

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 410

Chain	Residue
A	ACT423
A	HOH575

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 411

Chain	Residue
A	TYR153
A	HOH501
G	CYS149
G	LEU152
G	TYR153
G	GLU348

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 412

Chain	Residue
A	TRP307
A	ASP308
A	THR309
A	ASN312
A	ASN314
A	LEU315
A	ASP358

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 413

Chain	Residue
A	ALA311
A	ASN313
A	LYS349

site_id	BC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO A 414

Chain	Residue
A	LEU152
A	TYR153
A	ACT423
A	HOH594
A	HOH689
G	LEU152
G	TYR153
G	EDO407

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 415

Chain	Residue
A	THR309
A	ILE317
A	PRO318

site_id	BC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 416

Chain	Residue
A	ASN138
A	CYS352

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 417

Chain	Residue
A	GLY227
A	ASN228
A	LEU370
A	HOH666
E	ARG144

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 418

Chain	Residue
A	LEU347
A	GLU348
A	LYS349
A	HOH509
G	EDO405

site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 419

Chain	Residue
I	ILE206

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 421

Chain	Residue
A	GLY183
A	ASN184
I	GLN204

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO A 422

Chain	Residue
A	LEU350
A	HOH509
G	LYS301

site_id	CC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT A 423

Chain	Residue
A	EDO414
A	HOH601
G	LEU152
A	SER125
A	TYR153
A	PRO155
A	LEU363
A	EDO410

site_id	CC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 424

Chain	Residue
A	HIS302
A	ASP343
A	HOH528
G	ARG144
G	GLY145
G	SER148
G	HOH522

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 425

Chain	Residue
A	ARG144
A	GLY145
A	SER148
A	GLU348
A	HOH539
G	HIS302
G	ASP343

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT A 426

Chain	Residue
A	TYR170
A	HOH650
E	GLY226
E	ASN228
E	LEU370
E	HOH667

site_id	CC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT A 427

Chain	Residue
A	CYS149
A	TYR153
A	LEU344
A	VAL345
A	GLY346
A	LEU347
A	EDO407

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 401

Chain	Residue
B	TRP307
B	ASP308
B	ASN312
B	ASN314
B	LEU315
B	ASP358

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 402

Chain	Residue
B	PHE209
B	PRO210
B	ASN211
B	THR212
B	GLU246
B	ARG249

site_id	DC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 403

Chain	Residue
B	CYS149
B	TYR153
B	LEU344
B	VAL345
B	GLY346
B	LEU347
I	EDO414
I	ACT419

site_id	DC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 404

Chain	Residue
B	SER341
B	EDO406
I	SER148

site_id	DC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 405

Chain	Residue
B	SER125
B	TYR153
B	EDO406
B	HOH573
I	LEU152

site_id	DC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 406

Chain	Residue
B	THR123
B	EDO404
B	EDO405
B	HOH619
I	ALA151

site_id	DC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 408

Chain	Residue
B	ARG144
B	GLU348
I	HIS302
I	ASP343

site_id	DC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 409

Chain	Residue
B	GLU205
B	ILE206
G	THR253

site_id	DC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 410

Chain	Residue
B	ARG241
B	GLU279
B	HOH597
B	HOH639

site_id	DC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 411

Chain	Residue
B	ARG198
B	LYS200
B	SER224
B	LEU225
B	GLY226
B	GLY227
B	HOH602

site_id	EC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 412

Chain	Residue
B	LEU286
B	PRO287
B	VAL290
B	PHE291
B	HOH528

site_id	EC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO B 413

Chain	Residue
B	TYR188

site_id	EC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 414

Chain	Residue
B	HIS302
B	SER341
B	LEU342
I	HOH578

site_id	EC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 415

Chain	Residue
B	TYR178
B	THR179
B	ILE180
B	LYS196

site_id	EC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 416

Chain	Residue
B	PRO165
B	PRO166
B	ALA169

site_id	EC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B 417

Chain	Residue
B	ASN184
B	MET215
B	ASN217
B	HOH576
G	GLU260

site_id	EC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 418

Chain	Residue
B	ARG144
B	SER148
B	ARG174

site_id	EC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO B 419

Chain	Residue
B	CYS147
B	ALA151
B	ARG174
B	ALA175
B	SER177
B	TYR178
B	HOH521
B	HOH559

site_id	EC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO B 420

Chain	Residue
B	LEU297
B	GLY298
B	HOH584
B	HOH586
E	GLN278
E	LYS282

site_id	FC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO B 421

Chain	Residue
B	TYR305
B	LYS322

site_id	FC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 422

Chain	Residue
B	CYS168
B	GLU185
B	PHE189

site_id	FC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT B 423

Chain	Residue
B	THR179
B	LEU194
B	LYS196
B	VAL199
B	PHE201
B	HOH558

site_id	FC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT B 424

Chain	Residue
B	ILE181
B	PHE201
G	PRO210

site_id	FC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT B 425

Chain	Residue
B	ARG276
B	ASP277
B	HIS323
B	HOH512
B	HOH544

site_id	FC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE 6AH C 101

Chain	Residue
B	GLU162
B	SER239
C	DC2
C	DG4
C	HOH204
J	DT8

site_id	FC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 6AH D 101

Chain	Residue
A	GLU162
A	SER239
D	DC2
D	DG4
D	DA5
D	HOH201
H	DT8

site_id	FC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO D 102

Chain	Residue
D	DA6
D	DT7
D	EDO103
G	THR240
G	GLU242
G	HIS243

site_id	FC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D 103

Chain	Residue
D	DT7
D	EDO102
D	HOH210
H	DA5
H	HOH203

site_id	GC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D 104

Chain	Residue
A	THR240
A	GLU242
D	DA5

site_id	GC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO E 401

Chain	Residue
E	ASN289
E	PHE291
E	PHE330
E	ARG331
E	ALA332
E	GLU333
E	HOH504
E	HOH577
I	EDO405

site_id	GC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 402

Chain	Residue
E	TRP307
E	ASP308
E	ASN312
E	ASN314
E	LEU315
E	ASP358

site_id	GC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO E 403

Chain	Residue
E	TYR153
E	ASP343
E	HOH664
K	CYS149
K	LEU152
K	GLU348
K	EDO412

site_id	GC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 404

Chain	Residue
E	PHE209
E	PRO210
E	ASN211
E	GLU246
E	ARG249

site_id	GC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 405

Chain	Residue
E	ASP263
E	THR265
E	ARG331
E	ALA332
E	GLU333

site_id	GC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 406

Chain	Residue
E	GLN304
E	TYR305
E	ASP308
E	LEU344
E	TRP360

site_id	GC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 407

Chain	Residue
E	SER148
E	ALA151
K	SER341
K	HOH528
K	HOH579

site_id	GC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO E 408

Chain	Residue
E	ACT422
K	EDO403

site_id	HC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 409

Chain	Residue
A	VAL369
E	GLY133
E	LEU134
E	GLY136
E	HOH549
E	HOH645

site_id	HC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO E 410

Chain	Residue
E	GLY335
E	ILE338
E	HOH545
E	HOH551

site_id	HC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO E 411

Chain	Residue
E	LYS299
E	GLN304
E	EDO418
E	HOH646

site_id	HC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO E 412

Chain	Residue
E	HIS302
E	SER341
E	LEU342

site_id	HC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO E 413

Chain	Residue
E	GLU295
E	PHE296

site_id	HC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO E 414

Chain	Residue
E	CYS149
E	TYR153
E	VAL345
E	GLY346
E	LEU347
K	EDO409
K	EDO412

site_id	HC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 415

Chain	Residue
E	ASP277
E	TRP294
E	GLN304
E	ARG324
E	EDO418
E	HOH624

site_id	HC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 416

Chain	Residue
E	CYS283
E	GLY285
E	PRO287
E	HOH522
I	ARG144

site_id	HC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO E 417

Chain	Residue
A	LYS173
E	SER264
E	GLU333
E	HIS336
E	HOH520
E	HOH524
E	HOH571
E	HOH627

site_id	IC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 418

Chain	Residue
E	ASP277
E	LYS299
E	EDO411
E	EDO415
E	HOH624

site_id	IC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO E 419

Chain	Residue
E	ILE181
E	PHE201
E	HOH666

site_id	IC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO E 420

Chain	Residue
E	ASN313
E	ARG316
E	CYS352
E	GLY353
E	ARG354
E	HOH532

site_id	IC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT E 421

Chain	Residue
E	THR179
E	LEU194
E	LYS196
E	VAL199
E	PHE201
E	HOH607
E	HOH649

site_id	IC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT E 422

Chain	Residue
E	SER125
E	TYR153
E	EDO408
K	LEU152

site_id	IC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT E 423

Chain	Residue
E	LYS172
E	ILE180
E	HOH546

site_id	IC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT E 424

Chain	Residue
E	ARG276
E	ASP277
E	LYS322
E	HIS323
E	HOH543

site_id	IC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 6AH F 101

Chain	Residue
E	GLU162
E	SER239
F	DC2
F	DG4
L	DT8

site_id	IC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO F 102

Chain	Residue
F	DA5
F	HOH205
F	HOH212
F	HOH222

site_id	JC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO K 401

Chain	Residue
K	TRP307
K	ASP308
K	THR309
K	ASN312
K	ASN314
K	LEU315
K	ASP358

site_id	JC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO K 402

Chain	Residue
E	ARG144
E	GLY145
E	SER148
E	GLU348
K	HIS302
K	ASP343
K	HOH514
K	HOH579

site_id	JC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO K 403

Chain	Residue
E	SER341
E	EDO408
E	HOH617
K	SER148
K	ALA151

site_id	JC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO K 404

Chain	Residue
E	HIS302
K	ARG144
K	GLY145
K	SER148
K	HOH519

site_id	JC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO K 405

Chain	Residue
E	LEU347
E	GLU348
E	LYS349
K	ALA311
K	EDO408
K	HOH516

site_id	JC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO K 406

Chain	Residue
K	TYR153
K	SER154

site_id	JC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO K 407

Chain	Residue
K	LEU139
K	TYR170

site_id	JC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO K 408

Chain	Residue
K	TYR305
K	ASP308
K	ALA311
K	LEU344
K	TRP360
K	EDO405

site_id	JC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO K 409

Chain	Residue
E	CYS149
E	GLU348
E	EDO414
K	TYR153
K	ASP343
K	LEU344

site_id	KC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO K 410

Chain	Residue
K	THR309
K	ILE317
K	PRO318
K	ALA319
K	ALA320

site_id	KC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO K 411

Chain	Residue
K	GLN304
K	TYR305
K	HOH626

site_id	KC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE EDO K 412

Chain	Residue
E	EDO403
E	EDO414
K	CYS149
K	TYR153
K	LEU344
K	VAL345
K	GLY346
K	LEU347

site_id	KC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO K 413

Chain	Residue
G	GLY136
G	PRO140
G	TYR170
K	GLY136
K	CYS137

site_id	KC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO K 414

Chain	Residue
K	ARG241
K	ARG276
K	GLN278
K	ACT415
K	HOH502
K	HOH580

site_id	KC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT K 415

Chain	Residue
K	ASP277
K	GLN278
K	HIS323
K	EDO414

site_id	KC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT K 416

Chain	Residue
K	LYS310
K	ALA311
K	LYS349

site_id	KC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT K 417

Chain	Residue
K	PHE209
K	PRO210
K	ASN211
K	GLU246
K	ARG249
K	THR253

site_id	KC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 6AH L 101

Chain	Residue
F	HOH220
K	GLU162
K	ARG216
K	SER239
L	DC2

site_id	LC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO G 401

Chain	Residue
G	PHE209
G	PRO210
G	ASN211
G	GLU246
G	ARG249

site_id	LC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO G 402

Chain	Residue
G	PHE296
G	EDO404

site_id	LC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO G 403

Chain	Residue
A	SER148
A	ALA151
G	SER341
G	EDO406
G	HOH524
G	HOH594

site_id	LC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO G 404

Chain	Residue
G	GLY298
G	EDO402
G	HOH601

site_id	LC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO G 405

Chain	Residue
A	EDO418
G	TYR305
G	ASP308
G	ALA311
G	TRP360

site_id	LC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO G 406

Chain	Residue
A	ALA151
G	EDO403
G	EDO407
G	HOH524

site_id	LC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO G 407

Chain	Residue
A	LEU152
A	EDO414
G	SER125
G	TYR153
G	SER154
G	PRO155
G	EDO406

site_id	LC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO G 408

Chain	Residue
G	GLU205
G	LYS257

site_id	LC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO G 409

Chain	Residue
G	TRP307
G	ASP308
G	ASN312
G	ASN314
G	LEU315
G	ASP358

site_id	MC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO G 410

Chain	Residue
A	ASP351
G	LEU297
G	GLY298
G	PRO300

site_id	MC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO G 411

Chain	Residue
G	ASP135
G	ASN314
G	ARG316
G	ARG354

site_id	MC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT G 412

Chain	Residue
G	ARG276
G	ASP277
G	HIS323
G	HOH526

site_id	MC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACT G 413

Chain	Residue
G	ARG241
G	GLU279

site_id	MC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT G 414

Chain	Residue
G	LYS310
G	ALA311
G	LYS349

site_id	MC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 6AH H 101

Chain	Residue
G	GLU162
G	SER239
H	DC2

site_id	MC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO H 102

Chain	Residue
A	EDO403
H	DT7
H	DT8

site_id	MC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO H 103

Chain	Residue
A	MET214
H	DT7
H	HOH201
H	HOH202
H	HOH206

site_id	MC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO H 104

Chain	Residue
D	DC9
H	DC2
H	DG4

site_id	NC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO I 401

Chain	Residue
I	ALA311
I	ASN313
I	LYS349
I	EDO403

site_id	NC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO I 402

Chain	Residue
I	THR179
I	LEU194
I	LYS196
I	VAL199
I	PHE201

site_id	NC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO I 403

Chain	Residue
I	ALA311
I	LEU347
I	PHE355
I	EDO401
I	EDO409
I	EDO410

site_id	NC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO I 404

Chain	Residue
I	GLN304
I	TYR305
I	ASP308
I	ALA311
I	TRP360
I	EDO410

site_id	NC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO I 405

Chain	Residue
E	PHE291
E	GLU334
E	EDO401
I	ALA169
I	ACT420
I	HOH503

site_id	NC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO I 406

Chain	Residue
B	SER148
I	SER341
I	HOH550

site_id	NC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO I 407

Chain	Residue
A	GLU185
A	GLU186
I	CYS168
I	ILE180

site_id	NC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE EDO I 408

Chain	Residue
B	TYR153
B	ASP343
I	SER148
I	CYS149
I	LEU152
I	GLU348
I	ACT418
I	ACT419
I	HOH542

site_id	NC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO I 409

Chain	Residue
B	LEU347
B	HOH542
I	LYS349
I	EDO403
I	HOH512

site_id	OC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO I 410

Chain	Residue
B	GLU348
B	LYS349
I	ALA311
I	EDO403
I	EDO404
I	HOH517

site_id	OC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO I 411

Chain	Residue
I	ASP277
I	VAL280
I	GLU295
I	ARG324
I	ARG327
I	HOH568
I	HOH611

site_id	OC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO I 412

Chain	Residue
E	CYS283
I	GLU141
I	ARG144
I	ASP351

site_id	OC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO I 413

Chain	Residue
A	CYS168
A	LYS172
A	THR182
A	ASN184
A	GLU185
A	PHE189
I	GLU185

site_id	OC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO I 414

Chain	Residue
B	CYS149
B	LEU152
B	GLU348
B	EDO403
B	HOH567
I	TYR153
I	ASP343

site_id	OC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO I 415

Chain	Residue
I	LYS172
I	HOH624

site_id	OC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO I 416

Chain	Residue
I	ASP277
I	GLN304
I	ARG324

site_id	OC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACT I 417

Chain	Residue
I	PHE209
I	PRO210
I	ASN211
I	GLU246
I	ARG249
I	THR253

site_id	OC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACT I 418

Chain	Residue
B	HIS302
B	ASP343
I	GLY145
I	EDO408
I	HOH542

site_id	PC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACT I 419

Chain	Residue
B	EDO403
I	CYS149
I	TYR153
I	GLY346
I	LEU347
I	GLU348
I	EDO408

site_id	PC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT I 420

Chain	Residue
I	PRO165
I	LYS172
I	EDO405

site_id	PC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 6AH J 101

Chain	Residue
I	GLU162
I	SER239
J	DC2
J	DG4
J	HOH206

site_id	PC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO J 102

Chain	Residue
I	LEU134
J	DC2

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton donor/acceptor => ECO:0000305\|PubMed:23104055, ECO:0000305\|PubMed:27060144

Chain	Residue	Details
A	ASP272
B	ASP272
E	ASP272
K	ASP272
G	ASP272
I	ASP272

site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:23104055, ECO:0000269\|PubMed:27099339, ECO:0007744\|PDB:4GYZ, ECO:0007744\|PDB:4GZ2, ECO:0007744\|PDB:5J42

Chain	Residue	Details
A	ASP132
B	ASP132
E	ASP132
K	ASP132
G	ASP132
I	ASP132

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:23104055, ECO:0000269\|PubMed:24808172, ECO:0000269\|PubMed:27099339, ECO:0007744\|PDB:4GYZ, ECO:0007744\|PDB:4GZ1, ECO:0007744\|PDB:4GZ2, ECO:0007744\|PDB:4PUQ, ECO:0007744\|PDB:5HT2, ECO:0007744\|PDB:5INP, ECO:0007744\|PDB:5J42

Chain	Residue	Details
A	GLU162
B	GLU162
E	GLU162
K	GLU162
G	GLU162
I	GLU162

site_id	SWS_FT_FI4
Number of Residues	6
Details	SITE: Interaction with 5' end of substrate DNA => ECO:0000269\|PubMed:23104055, ECO:0000269\|PubMed:27060144

Chain	Residue	Details
A	TYR188
B	TYR188
E	TYR188
K	TYR188
G	TYR188
I	TYR188

site_id	SWS_FT_FI5
Number of Residues	12
Details	SITE: Interaction with 5' end of substrate DNA => ECO:0000269\|PubMed:23104055, ECO:0000269\|PubMed:24808172, ECO:0000269\|PubMed:27060144

Chain	Residue	Details
A	TRP307
G	HIS359
I	TRP307
I	HIS359
A	HIS359
B	TRP307
B	HIS359
E	TRP307
E	HIS359
K	TRP307
K	HIS359
G	TRP307

site_id	SWS_FT_FI6
Number of Residues	6
Details	SITE: Interaction with 5' end of substrate DNA => ECO:0000269\|PubMed:23104055

Chain	Residue	Details
A	PHE325
B	PHE325
E	PHE325
K	PHE325
G	PHE325
I	PHE325

227111

PDB entries from 2024-11-06

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