Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GYZ

Mus Musculus Tdp2 Bound to dAMP and Mg2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity
C	0003824	molecular_function	catalytic activity
D	0003824	molecular_function	catalytic activity
E	0003824	molecular_function	catalytic activity
F	0003824	molecular_function	catalytic activity
G	0003824	molecular_function	catalytic activity
H	0003824	molecular_function	catalytic activity
I	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	BINDING SITE FOR RESIDUE D5M A 401

Chain	Residue
A	ASN130
A	MG402
A	HOH516
A	HOH521
A	HOH531
B	SER148
B	CYS149
B	LEU152
B	GLU348
A	GLU162
A	HIS236
A	SER239
A	ASP272
A	ASN274
A	TRP307
A	PHE325
A	HIS359

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 402

Chain	Residue
A	GLU162
A	D5M401
A	HOH516
A	HOH521
A	HOH531
A	HOH554

site_id	AC3
Number of Residues	15
Details	BINDING SITE FOR RESIDUE D5M B 401

Chain	Residue
B	ASN130
B	GLU162
B	HIS236
B	SER239
B	ASP272
B	ASN274
B	ARG276
B	TRP307
B	PHE325
B	HIS359
B	MG402
B	HOH511
B	HOH512
B	HOH516
D	SER148

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG B 402

Chain	Residue
B	GLU162
B	D5M401
B	HOH510
B	HOH511
B	HOH512
B	HOH516

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL C 401

Chain	Residue
C	TYR153
C	GLY346
C	LEU347
C	HOH518

site_id	AC6
Number of Residues	14
Details	BINDING SITE FOR RESIDUE D5M C 402

Chain	Residue
C	ASN130
C	GLU162
C	HIS236
C	SER239
C	ASP272
C	ASN274
C	ARG276
C	TRP307
C	HIS359
C	MG403
C	HOH536
C	HOH546
C	HOH547
H	SER148

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG C 403

Chain	Residue
C	GLU162
C	D5M402
C	HOH536
C	HOH546
C	HOH547
C	HOH548

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL D 401

Chain	Residue
D	TYR153
D	GLY346
D	LEU347

site_id	AC9
Number of Residues	16
Details	BINDING SITE FOR RESIDUE D5M D 402

Chain	Residue
D	ASN130
D	GLU162
D	HIS236
D	SER239
D	ASP272
D	ASN274
D	PHE325
D	HIS359
D	MG403
D	HOH528
D	HOH529
D	HOH531
I	SER148
I	CYS149
I	LEU152
I	GLU348

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG D 403

Chain	Residue
D	GLU162
D	D5M402
D	HOH528
D	HOH529
D	HOH531
D	HOH538

site_id	BC2
Number of Residues	17
Details	BINDING SITE FOR RESIDUE D5M E 401

Chain	Residue
E	SER239
E	THR240
E	ASP272
E	ASN274
E	ARG276
E	PHE325
E	HIS359
E	MG402
E	HOH532
E	HOH534
E	HOH540
A	SER148
A	CYS149
A	LEU152
E	ASN130
E	GLU162
E	HIS236

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG E 402

Chain	Residue
E	GLU162
E	D5M401
E	HOH521
E	HOH532
E	HOH533
E	HOH534

site_id	BC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 F 401

Chain	Residue
F	ASN130
F	GLU162
F	HIS236
F	SER239
F	ASP272
F	ASN274
F	HIS359
F	MG402
F	HOH510
F	HOH511

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG F 402

Chain	Residue
F	GLU162
F	PO4401
F	HOH510
F	HOH511
F	HOH518
F	HOH523

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG G 401

Chain	Residue
G	ASP132
G	GLU162
G	HOH536
G	HOH537
G	HOH538
G	HOH539

site_id	BC7
Number of Residues	18
Details	BINDING SITE FOR RESIDUE D5M H 401

Chain	Residue
E	SER148
E	LEU152
H	ASN130
H	GLU162
H	HIS236
H	SER239
H	THR240
H	ASP272
H	ASN274
H	ARG276
H	TRP307
H	PHE325
H	HIS359
H	MG402
H	HOH516
H	HOH520
H	HOH521
H	HOH530

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG H 402

Chain	Residue
H	GLU162
H	D5M401
H	HOH516
H	HOH519
H	HOH520
H	HOH521

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL I 401

Chain	Residue
I	HIS302
I	LEU342

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG I 402

Chain	Residue
I	ASP132
I	GLU162
I	HOH529
I	HOH530
I	HOH537

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	Region: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27060144","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	111
Details	Region: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24808172","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27060144","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	9
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"27060144","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27099339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GYZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GZ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24808172","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27099339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GYZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GZ1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4GZ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PUQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HT2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5J42","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	9
Details	Site: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27060144","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	18
Details	Site: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24808172","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27060144","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	9
Details	Site: {"description":"Interaction with 5' end of substrate DNA","evidences":[{"source":"PubMed","id":"23104055","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)