4GYU

Crystal Structure of New Delhi Metallo-beta-Lactamase-1 A121F mutant from Klebsiella pneumoniae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0016787	molecular_function	hydrolase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
A	0046677	biological_process	response to antibiotic
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE IMD A 301

Chain	Residue
A	PHE121
A	ASN146
A	ALA149
A	VAL155
A	ALA156
A	ALA157
A	HOH517

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE IMD A 302

Chain	Residue
A	VAL118
A	HIS120
A	LYS125
A	HOH517
A	ASP90
A	THR91

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE P6G A 303

Chain	Residue
A	GLN38
A	GLU40
A	GLY42
A	PHE51
A	GLN53
A	TRP59
A	ARG81
A	GLU108
A	HOH429
A	HOH525

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG A 304

Chain	Residue
A	HIS133
A	ALA156
A	ALA157
A	HOH443
A	HOH470
A	HOH480
A	HOH523

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 305

Chain	Residue
A	ILE198
A	THR201
A	ILE203
A	LYS242
A	ALA243
A	HOH417

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 306

Chain	Residue
A	GLN107
A	GLU108
A	HOH428
A	HOH443
A	HOH470
A	HOH480
A	HOH530

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22713171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25815530","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22713171","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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