4GYQ

Crystal Structure of New Delhi Metallo-beta-Lactamase-1 D223A mutant from Klebsiella pneumoniae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008270	molecular_function	zinc ion binding
A	0008800	molecular_function	beta-lactamase activity
A	0017001	biological_process	antibiotic catabolic process
A	0042597	cellular_component	periplasmic space
B	0008270	molecular_function	zinc ion binding
B	0008800	molecular_function	beta-lactamase activity
B	0017001	biological_process	antibiotic catabolic process
B	0042597	cellular_component	periplasmic space
C	0008270	molecular_function	zinc ion binding
C	0008800	molecular_function	beta-lactamase activity
C	0017001	biological_process	antibiotic catabolic process
C	0042597	cellular_component	periplasmic space
D	0008270	molecular_function	zinc ion binding
D	0008800	molecular_function	beta-lactamase activity
D	0017001	biological_process	antibiotic catabolic process
D	0042597	cellular_component	periplasmic space

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO A 301

Chain	Residue
A	GLY47
A	ASP48
A	LEU49
A	ASP96
A	GLN97
A	GLN100
B	ARG45

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site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 302

Chain	Residue
A	ASP202
A	ILE203
A	ALA243
A	ILE198
A	THR201

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B 301

Chain	Residue
B	ASP66
B	MET126
B	HOH614

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 301

Chain	Residue
C	GLY178
C	HOH481
C	HOH501
C	HOH584
C	HOH591

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	23
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22713171","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25815530","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"22713171","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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