4GV1

PKB alpha in complex with AZD5363

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 0XZ A 501

Chain	Residue
A	GLY157
A	MET227
A	GLU228
A	ALA230
A	GLU234
A	GLU278
A	MET281
A	ASP292
A	PHE438
A	GOL505
A	HOH642
A	LYS158
A	HOH726
A	GLY159
A	GLY162
A	LYS163
A	VAL164
A	ALA177
A	LYS179
A	LEU181

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 502

Chain	Residue
A	LYS154
A	ASP434
A	THR435
A	ARG436
A	HOH732
A	HOH939

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 503

Chain	Residue
A	LYS179
A	ILE186
A	GLU191
A	THR195
A	GLU198
A	ASP292
A	GLY294
A	HOH854
A	HOH855

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 504

Chain	Residue
A	PHE309
A	CYS310
A	GLY311
A	THR312
A	PRO313
A	LEU316
A	HOH967

---

site_id	AC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 505

Chain	Residue
A	GLY157
A	LYS158
A	GLU234
A	PHE236
A	PHE442
A	0XZ501
A	HOH638
A	HOH709
A	HOH852

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	34
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGTFGKVIlVkekatgryyamkilkkevIVAK

Chain	Residue	Details
A	LEU156-LYS189

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKleNLML

Chain	Residue	Details
A	VAL270-LEU282

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"Cleavage; by caspase-3","evidences":[{"source":"UniProtKB","id":"P31750","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by TNK2","evidences":[{"source":"PubMed","id":"20333297","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine; by IKKE, PDPK1 and TBK1","evidences":[{"source":"PubMed","id":"15718470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18456494","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20333297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20481595","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21464307","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8978681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9512493","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by IKKE, MTOR, PRKDC and TBK1; alternate","evidences":[{"source":"PubMed","id":"14761976","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15047712","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15262962","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15718470","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16266983","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17013611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20333297","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20978158","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21464307","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23799035","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8978681","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9736715","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) threonine","evidences":[{"source":"PubMed","id":"22629392","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"source":"UniProtKB","id":"P31750","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22410793","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---