4GUX
Crystal structure of trypsin:MCoTi-II complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| D | 0004866 | molecular_function | endopeptidase inhibitor activity |
| D | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0006952 | biological_process | defense response |
| D | 0030414 | molecular_function | peptidase inhibitor activity |
| E | 0004866 | molecular_function | endopeptidase inhibitor activity |
| E | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| E | 0005576 | cellular_component | extracellular region |
| E | 0006952 | biological_process | defense response |
| E | 0030414 | molecular_function | peptidase inhibitor activity |
| F | 0004866 | molecular_function | endopeptidase inhibitor activity |
| F | 0004867 | molecular_function | serine-type endopeptidase inhibitor activity |
| F | 0005576 | cellular_component | extracellular region |
| F | 0006952 | biological_process | defense response |
| F | 0030414 | molecular_function | peptidase inhibitor activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 301 |
| Chain | Residue |
| A | GLU72 |
| A | ASN74 |
| A | VAL77 |
| A | GLU82 |
| A | HOH544 |
| A | HOH548 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT A 302 |
| Chain | Residue |
| A | HOH414 |
| B | GLY24 |
| B | LYS156 |
| B | HOH449 |
| A | GLY24 |
| A | LYS156 |
| A | HOH409 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 301 |
| Chain | Residue |
| B | GLU72 |
| B | ASN74 |
| B | VAL77 |
| B | GLU82 |
| B | HOH564 |
| B | HOH565 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT B 302 |
| Chain | Residue |
| B | TYR25 |
| B | CYS27 |
| B | THR31 |
| B | LEU137 |
| B | HOH545 |
| B | HOH556 |
| B | HOH631 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 301 |
| Chain | Residue |
| C | GLU72 |
| C | ASN74 |
| C | VAL77 |
| C | GLU82 |
| C | HOH438 |
| C | HOH580 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC |
| Chain | Residue | Details |
| A | VAL56-CYS61 |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV |
| Chain | Residue | Details |
| A | ASP191-VAL202 |
| site_id | PS00286 |
| Number of Residues | 20 |
| Details | SQUASH_INHIBITOR Squash family of serine protease inhibitors signature. CPkilkkCrrDsDCpgaCiC |
| Chain | Residue | Details |
| D | CYS8-CYS27 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 660 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 21 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 99 |
| Details | Peptide: {"description":"Trypsin inhibitor 2","featureId":"PRO_0000044858"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Site: {"description":"Reactive bond"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Cyclopeptide (Ser-Gly)","evidences":[{"source":"PubMed","id":"10801322","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Cross-link: {"description":"Isoaspartyl glycine isopeptide (Asp-Gly); alternate","evidences":[{"source":"PubMed","id":"10801322","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
