4GUK

New crystal form structure of human NCS1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005245	molecular_function	voltage-gated calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
A	0009966	biological_process	regulation of signal transduction
A	0010975	biological_process	regulation of neuron projection development
A	0014069	cellular_component	postsynaptic density
A	0016020	cellular_component	membrane
A	0030424	cellular_component	axon
A	0030425	cellular_component	dendrite
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0070588	biological_process	calcium ion transmembrane transport
B	0005245	molecular_function	voltage-gated calcium channel activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
B	0009966	biological_process	regulation of signal transduction
B	0010975	biological_process	regulation of neuron projection development
B	0014069	cellular_component	postsynaptic density
B	0016020	cellular_component	membrane
B	0030424	cellular_component	axon
B	0030425	cellular_component	dendrite
B	0046872	molecular_function	metal ion binding
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0070588	biological_process	calcium ion transmembrane transport
C	0005245	molecular_function	voltage-gated calcium channel activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
C	0009966	biological_process	regulation of signal transduction
C	0010975	biological_process	regulation of neuron projection development
C	0014069	cellular_component	postsynaptic density
C	0016020	cellular_component	membrane
C	0030424	cellular_component	axon
C	0030425	cellular_component	dendrite
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0070588	biological_process	calcium ion transmembrane transport
D	0005245	molecular_function	voltage-gated calcium channel activity
D	0005509	molecular_function	calcium ion binding
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0008048	molecular_function	calcium sensitive guanylate cyclase activator activity
D	0009966	biological_process	regulation of signal transduction
D	0010975	biological_process	regulation of neuron projection development
D	0014069	cellular_component	postsynaptic density
D	0016020	cellular_component	membrane
D	0030424	cellular_component	axon
D	0030425	cellular_component	dendrite
D	0046872	molecular_function	metal ion binding
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0070588	biological_process	calcium ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PG4 A 201

Chain	Residue
A	PHE22
A	GLN29
A	TRP30
A	SER93
A	ARG94
A	ASP187

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE PG4 A 202

Chain	Residue
A	LEU183
A	EDO205
A	TYR108
A	VAL125
A	ARG148

---

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 203

Chain	Residue
A	EDO204

---

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 204

Chain	Residue
A	TYR52
A	EDO203

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 205

Chain	Residue
A	PG4202

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 206

Chain	Residue
A	ASP73
A	ASN75
A	ASP77
A	ARG79
A	GLU84
A	HOH379

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 207

Chain	Residue
A	ASP109
A	ASP111
A	ASP113
A	TYR115
A	GLU120
A	HOH370

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 208

Chain	Residue
A	ASP157
A	ASN159
A	ASP161
A	LYS163
A	GLU168
A	HOH371

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 209

Chain	Residue
A	THR17
B	LYS174
B	ALA175
B	ASP176
B	PRO177
B	HOH382

---

site_id	BC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE PG4 C 201

Chain	Residue
C	TYR103
C	VAL120
C	ARG141
C	PHE162
C	SER166
C	ILE172
C	LEU176
C	HOH390
C	HOH393

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE P3G C 202

Chain	Residue
C	PHE17
C	GLN24
C	TRP25
C	SER88
C	ASP180

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 203

Chain	Residue
C	ASP68
C	ASN70
C	ASP72
C	ARG74
C	GLU79
C	HOH391

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 204

Chain	Residue
C	ASP104
C	ASP106
C	ASP108
C	TYR110
C	GLU115
C	HOH380

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 205

Chain	Residue
C	ASP150
C	ASN152
C	ASP154
C	LYS156
C	GLU161
C	HOH381

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE P2G C 206

Chain	Residue
C	LYS95
C	TRP98

---

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA C 207

Chain	Residue
C	THR12
D	LYS174
D	ALA175
D	PRO177
D	HOH369

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 201

Chain	Residue
B	ASP73
B	ASN75
B	ASP77
B	ARG79
B	GLU84
B	HOH377

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 202

Chain	Residue
B	ASP109
B	ASP111
B	ASP113
B	TYR115
B	GLU120
B	HOH378

---

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 203

Chain	Residue
B	ASP157
B	ASN159
B	ASP161
B	LYS163
B	GLU168
B	HOH379

---

site_id	CC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PG4 B 204

Chain	Residue
B	SER173
B	ILE179
B	LEU183
B	P2G207
B	HOH400
B	HOH401
B	HOH402
B	TYR108
B	ARG148
B	PHE169

---

site_id	CC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ALA B 205

Chain	Residue
B	SER184
B	LEU185
B	LEU189

---

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO B 206

Chain	Residue
B	TYR52
B	TRP103
B	P2G207
B	P2G208

---

site_id	CC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE P2G B 207

Chain	Residue
B	PG4204
B	EDO206
B	P2G208

---

site_id	CC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE P2G B 208

Chain	Residue
B	LYS100
B	TRP103
B	EDO206
B	P2G207

---

site_id	CC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 B 209

Chain	Residue
B	TRP30
B	SER93
B	ARG94
B	ASP187

---

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 210

Chain	Residue
A	LYS174
A	ALA175
A	ASP176
A	PRO177
B	THR17
B	HOH390

---

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 201

Chain	Residue
D	ASP73
D	ASN75
D	ASP77
D	ARG79
D	GLU84
D	HOH379

---

site_id	DC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 202

Chain	Residue
D	ASP109
D	ASP111
D	ASP113
D	TYR115
D	GLU120
D	HOH361

---

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA D 203

Chain	Residue
D	ASP157
D	ASN159
D	ASP161
D	LYS163
D	GLU168
D	HOH362

---

site_id	DC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO D 204

Chain	Residue
D	TYR52
D	P2G205

---

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE P2G D 205

Chain	Residue
D	LYS100
D	ALA182
D	EDO204
D	PG4207

---

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PG4 D 206

Chain	Residue
D	TRP30
D	SER93
D	ARG94
D	ASP187

---

site_id	DC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PG4 D 207

Chain	Residue
D	TYR108
D	VAL125
D	ARG148
D	PHE169
D	SER173
D	LEU183
D	P2G205
D	HOH382

---

site_id	DC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA D 208

Chain	Residue
C	ALA168
D	THR17
D	THR20
D	PHE22
D	HOH391

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DENKDGRIEfsEF

Chain	Residue	Details
A	ASP73-PHE85
A	ASP109-MET121
A	ASP157-PHE169

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Domain: {"description":"EF-hand 1","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	140
Details	Domain: {"description":"EF-hand 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	140
Details	Domain: {"description":"EF-hand 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	140
Details	Domain: {"description":"EF-hand 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	32
Details	Region: {"description":"Interaction with IL1RAPL1","evidences":[{"source":"PubMed","id":"12783849","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	60
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P62168","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---