4GUK
New crystal form structure of human NCS1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005245 | molecular_function | voltage-gated calcium channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0008048 | molecular_function | calcium sensitive guanylate cyclase activator activity |
| A | 0010975 | biological_process | regulation of neuron projection development |
| A | 0014069 | cellular_component | postsynaptic density |
| A | 0030424 | cellular_component | axon |
| A | 0030425 | cellular_component | dendrite |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0045202 | cellular_component | synapse |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| B | 0005245 | molecular_function | voltage-gated calcium channel activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0008048 | molecular_function | calcium sensitive guanylate cyclase activator activity |
| B | 0010975 | biological_process | regulation of neuron projection development |
| B | 0014069 | cellular_component | postsynaptic density |
| B | 0030424 | cellular_component | axon |
| B | 0030425 | cellular_component | dendrite |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0045202 | cellular_component | synapse |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048471 | cellular_component | perinuclear region of cytoplasm |
| B | 0070588 | biological_process | calcium ion transmembrane transport |
| C | 0005245 | molecular_function | voltage-gated calcium channel activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0008048 | molecular_function | calcium sensitive guanylate cyclase activator activity |
| C | 0010975 | biological_process | regulation of neuron projection development |
| C | 0014069 | cellular_component | postsynaptic density |
| C | 0030424 | cellular_component | axon |
| C | 0030425 | cellular_component | dendrite |
| C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| C | 0045202 | cellular_component | synapse |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0048471 | cellular_component | perinuclear region of cytoplasm |
| C | 0070588 | biological_process | calcium ion transmembrane transport |
| D | 0005245 | molecular_function | voltage-gated calcium channel activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005794 | cellular_component | Golgi apparatus |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0008048 | molecular_function | calcium sensitive guanylate cyclase activator activity |
| D | 0010975 | biological_process | regulation of neuron projection development |
| D | 0014069 | cellular_component | postsynaptic density |
| D | 0030424 | cellular_component | axon |
| D | 0030425 | cellular_component | dendrite |
| D | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| D | 0045202 | cellular_component | synapse |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0048471 | cellular_component | perinuclear region of cytoplasm |
| D | 0070588 | biological_process | calcium ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PG4 A 201 |
| Chain | Residue |
| A | PHE22 |
| A | GLN29 |
| A | TRP30 |
| A | SER93 |
| A | ARG94 |
| A | ASP187 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE PG4 A 202 |
| Chain | Residue |
| A | LEU183 |
| A | EDO205 |
| A | TYR108 |
| A | VAL125 |
| A | ARG148 |
| site_id | AC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 203 |
| Chain | Residue |
| A | EDO204 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO A 204 |
| Chain | Residue |
| A | TYR52 |
| A | EDO203 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE EDO A 205 |
| Chain | Residue |
| A | PG4202 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 206 |
| Chain | Residue |
| A | ASP73 |
| A | ASN75 |
| A | ASP77 |
| A | ARG79 |
| A | GLU84 |
| A | HOH379 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 207 |
| Chain | Residue |
| A | ASP109 |
| A | ASP111 |
| A | ASP113 |
| A | TYR115 |
| A | GLU120 |
| A | HOH370 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 208 |
| Chain | Residue |
| A | ASP157 |
| A | ASN159 |
| A | ASP161 |
| A | LYS163 |
| A | GLU168 |
| A | HOH371 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 209 |
| Chain | Residue |
| A | THR17 |
| B | LYS174 |
| B | ALA175 |
| B | ASP176 |
| B | PRO177 |
| B | HOH382 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE PG4 C 201 |
| Chain | Residue |
| C | TYR103 |
| C | VAL120 |
| C | ARG141 |
| C | PHE162 |
| C | SER166 |
| C | ILE172 |
| C | LEU176 |
| C | HOH390 |
| C | HOH393 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE P3G C 202 |
| Chain | Residue |
| C | PHE17 |
| C | GLN24 |
| C | TRP25 |
| C | SER88 |
| C | ASP180 |
| site_id | BC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 203 |
| Chain | Residue |
| C | ASP68 |
| C | ASN70 |
| C | ASP72 |
| C | ARG74 |
| C | GLU79 |
| C | HOH391 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 204 |
| Chain | Residue |
| C | ASP104 |
| C | ASP106 |
| C | ASP108 |
| C | TYR110 |
| C | GLU115 |
| C | HOH380 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 205 |
| Chain | Residue |
| C | ASP150 |
| C | ASN152 |
| C | ASP154 |
| C | LYS156 |
| C | GLU161 |
| C | HOH381 |
| site_id | BC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE P2G C 206 |
| Chain | Residue |
| C | LYS95 |
| C | TRP98 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA C 207 |
| Chain | Residue |
| C | THR12 |
| D | LYS174 |
| D | ALA175 |
| D | PRO177 |
| D | HOH369 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 201 |
| Chain | Residue |
| B | ASP73 |
| B | ASN75 |
| B | ASP77 |
| B | ARG79 |
| B | GLU84 |
| B | HOH377 |
| site_id | BC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 202 |
| Chain | Residue |
| B | ASP109 |
| B | ASP111 |
| B | ASP113 |
| B | TYR115 |
| B | GLU120 |
| B | HOH378 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 203 |
| Chain | Residue |
| B | ASP157 |
| B | ASN159 |
| B | ASP161 |
| B | LYS163 |
| B | GLU168 |
| B | HOH379 |
| site_id | CC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE PG4 B 204 |
| Chain | Residue |
| B | SER173 |
| B | ILE179 |
| B | LEU183 |
| B | P2G207 |
| B | HOH400 |
| B | HOH401 |
| B | HOH402 |
| B | TYR108 |
| B | ARG148 |
| B | PHE169 |
| site_id | CC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ALA B 205 |
| Chain | Residue |
| B | SER184 |
| B | LEU185 |
| B | LEU189 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE EDO B 206 |
| Chain | Residue |
| B | TYR52 |
| B | TRP103 |
| B | P2G207 |
| B | P2G208 |
| site_id | CC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE P2G B 207 |
| Chain | Residue |
| B | PG4204 |
| B | EDO206 |
| B | P2G208 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE P2G B 208 |
| Chain | Residue |
| B | LYS100 |
| B | TRP103 |
| B | EDO206 |
| B | P2G207 |
| site_id | CC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 B 209 |
| Chain | Residue |
| B | TRP30 |
| B | SER93 |
| B | ARG94 |
| B | ASP187 |
| site_id | CC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 210 |
| Chain | Residue |
| A | LYS174 |
| A | ALA175 |
| A | ASP176 |
| A | PRO177 |
| B | THR17 |
| B | HOH390 |
| site_id | CC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 201 |
| Chain | Residue |
| D | ASP73 |
| D | ASN75 |
| D | ASP77 |
| D | ARG79 |
| D | GLU84 |
| D | HOH379 |
| site_id | DC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 202 |
| Chain | Residue |
| D | ASP109 |
| D | ASP111 |
| D | ASP113 |
| D | TYR115 |
| D | GLU120 |
| D | HOH361 |
| site_id | DC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA D 203 |
| Chain | Residue |
| D | ASP157 |
| D | ASN159 |
| D | ASP161 |
| D | LYS163 |
| D | GLU168 |
| D | HOH362 |
| site_id | DC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE EDO D 204 |
| Chain | Residue |
| D | TYR52 |
| D | P2G205 |
| site_id | DC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE P2G D 205 |
| Chain | Residue |
| D | LYS100 |
| D | ALA182 |
| D | EDO204 |
| D | PG4207 |
| site_id | DC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PG4 D 206 |
| Chain | Residue |
| D | TRP30 |
| D | SER93 |
| D | ARG94 |
| D | ASP187 |
| site_id | DC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PG4 D 207 |
| Chain | Residue |
| D | TYR108 |
| D | VAL125 |
| D | ARG148 |
| D | PHE169 |
| D | SER173 |
| D | LEU183 |
| D | P2G205 |
| D | HOH382 |
| site_id | DC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA D 208 |
| Chain | Residue |
| C | ALA168 |
| D | THR17 |
| D | THR20 |
| D | PHE22 |
| D | HOH391 |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DENKDGRIEfsEF |
| Chain | Residue | Details |
| A | ASP73-PHE85 | |
| A | ASP109-MET121 | |
| A | ASP157-PHE169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 60 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
| Chain | Residue | Details |
| A | ASP73 | |
| A | GLU120 | |
| A | ASP157 | |
| A | ASN159 | |
| A | ASP161 | |
| A | LYS163 | |
| A | GLU168 | |
| C | ASP68 | |
| C | ASN70 | |
| C | ASP72 | |
| C | ARG74 | |
| A | ASN75 | |
| C | GLU79 | |
| C | ASP104 | |
| C | ASP106 | |
| C | ASP108 | |
| C | TYR110 | |
| C | GLU115 | |
| C | ASP150 | |
| C | ASN152 | |
| C | ASP154 | |
| C | LYS156 | |
| A | ASP77 | |
| C | GLU161 | |
| B | ASP73 | |
| B | ASN75 | |
| B | ASP77 | |
| B | ARG79 | |
| B | GLU84 | |
| B | ASP109 | |
| B | ASP111 | |
| B | ASP113 | |
| B | TYR115 | |
| A | ARG79 | |
| B | GLU120 | |
| B | ASP157 | |
| B | ASN159 | |
| B | ASP161 | |
| B | LYS163 | |
| B | GLU168 | |
| D | ASP73 | |
| D | ASN75 | |
| D | ASP77 | |
| D | ARG79 | |
| A | GLU84 | |
| D | GLU84 | |
| D | ASP109 | |
| D | ASP111 | |
| D | ASP113 | |
| D | TYR115 | |
| D | GLU120 | |
| D | ASP157 | |
| D | ASN159 | |
| D | ASP161 | |
| D | LYS163 | |
| A | ASP109 | |
| D | GLU168 | |
| A | ASP111 | |
| A | ASP113 | |
| A | TYR115 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P62168 |
| Chain | Residue | Details |
| A | GLU81 | |
| C | GLU76 | |
| B | GLU81 | |
| D | GLU81 |
