Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GTY

Crystal structure of mouse Enpp1 in complex with GMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0005044	molecular_function	scavenger receptor activity
A	0006955	biological_process	immune response
A	0016787	molecular_function	hydrolase activity
A	0030247	molecular_function	polysaccharide binding
A	0046872	molecular_function	metal ion binding
B	0003676	molecular_function	nucleic acid binding
B	0005044	molecular_function	scavenger receptor activity
B	0006955	biological_process	immune response
B	0016787	molecular_function	hydrolase activity
B	0030247	molecular_function	polysaccharide binding
B	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00524
Number of Residues	21
Details	SMB_1 Somatomedin B domain (SMB) signature. CrCdaaCvslgn.CClDFqetC

Chain	Residue	Details
A	CYS102-CYS122
A	CYS146-CYS166

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	400
Details	Region: {"description":"Phosphodiesterase","evidences":[{"source":"PubMed","id":"23027977","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"23041369","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"23027977","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4GTY","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30356045","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27780639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27780639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27780639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Site: {"description":"Essential for catalytic activity","evidences":[{"source":"PubMed","id":"19329427","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"Q924C3","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19656770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23027977","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19656770","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23027977","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23041369","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"21240269","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23688339","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27780639","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3NKM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3NKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WAY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HRT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5INH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LIA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	42
Details	Region: {"description":"Required for secretion","evidences":[{"source":"PubMed","id":"19329427","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)