Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GTU

LIGAND-FREE HOMODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M4-4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004364	molecular_function	glutathione transferase activity
A	0004464	molecular_function	leukotriene-C4 synthase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0018916	biological_process	nitrobenzene metabolic process
A	0019899	molecular_function	enzyme binding
A	0042178	biological_process	xenobiotic catabolic process
A	0042759	biological_process	long-chain fatty acid biosynthetic process
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0043295	molecular_function	glutathione binding
A	0045171	cellular_component	intercellular bridge
B	0004364	molecular_function	glutathione transferase activity
B	0004464	molecular_function	leukotriene-C4 synthase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0016740	molecular_function	transferase activity
B	0016829	molecular_function	lyase activity
B	0018916	biological_process	nitrobenzene metabolic process
B	0019899	molecular_function	enzyme binding
B	0042178	biological_process	xenobiotic catabolic process
B	0042759	biological_process	long-chain fatty acid biosynthetic process
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0043295	molecular_function	glutathione binding
B	0045171	cellular_component	intercellular bridge
C	0004364	molecular_function	glutathione transferase activity
C	0004464	molecular_function	leukotriene-C4 synthase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006749	biological_process	glutathione metabolic process
C	0016740	molecular_function	transferase activity
C	0016829	molecular_function	lyase activity
C	0018916	biological_process	nitrobenzene metabolic process
C	0019899	molecular_function	enzyme binding
C	0042178	biological_process	xenobiotic catabolic process
C	0042759	biological_process	long-chain fatty acid biosynthetic process
C	0042802	molecular_function	identical protein binding
C	0042803	molecular_function	protein homodimerization activity
C	0043295	molecular_function	glutathione binding
C	0045171	cellular_component	intercellular bridge
D	0004364	molecular_function	glutathione transferase activity
D	0004464	molecular_function	leukotriene-C4 synthase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006749	biological_process	glutathione metabolic process
D	0016740	molecular_function	transferase activity
D	0016829	molecular_function	lyase activity
D	0018916	biological_process	nitrobenzene metabolic process
D	0019899	molecular_function	enzyme binding
D	0042178	biological_process	xenobiotic catabolic process
D	0042759	biological_process	long-chain fatty acid biosynthetic process
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0043295	molecular_function	glutathione binding
D	0045171	cellular_component	intercellular bridge
E	0004364	molecular_function	glutathione transferase activity
E	0004464	molecular_function	leukotriene-C4 synthase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0006749	biological_process	glutathione metabolic process
E	0016740	molecular_function	transferase activity
E	0016829	molecular_function	lyase activity
E	0018916	biological_process	nitrobenzene metabolic process
E	0019899	molecular_function	enzyme binding
E	0042178	biological_process	xenobiotic catabolic process
E	0042759	biological_process	long-chain fatty acid biosynthetic process
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0043295	molecular_function	glutathione binding
E	0045171	cellular_component	intercellular bridge
F	0004364	molecular_function	glutathione transferase activity
F	0004464	molecular_function	leukotriene-C4 synthase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0006749	biological_process	glutathione metabolic process
F	0016740	molecular_function	transferase activity
F	0016829	molecular_function	lyase activity
F	0018916	biological_process	nitrobenzene metabolic process
F	0019899	molecular_function	enzyme binding
F	0042178	biological_process	xenobiotic catabolic process
F	0042759	biological_process	long-chain fatty acid biosynthetic process
F	0042802	molecular_function	identical protein binding
F	0042803	molecular_function	protein homodimerization activity
F	0043295	molecular_function	glutathione binding
F	0045171	cellular_component	intercellular bridge
G	0004364	molecular_function	glutathione transferase activity
G	0004464	molecular_function	leukotriene-C4 synthase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006629	biological_process	lipid metabolic process
G	0006749	biological_process	glutathione metabolic process
G	0016740	molecular_function	transferase activity
G	0016829	molecular_function	lyase activity
G	0018916	biological_process	nitrobenzene metabolic process
G	0019899	molecular_function	enzyme binding
G	0042178	biological_process	xenobiotic catabolic process
G	0042759	biological_process	long-chain fatty acid biosynthetic process
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0043295	molecular_function	glutathione binding
G	0045171	cellular_component	intercellular bridge
H	0004364	molecular_function	glutathione transferase activity
H	0004464	molecular_function	leukotriene-C4 synthase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006629	biological_process	lipid metabolic process
H	0006749	biological_process	glutathione metabolic process
H	0016740	molecular_function	transferase activity
H	0016829	molecular_function	lyase activity
H	0018916	biological_process	nitrobenzene metabolic process
H	0019899	molecular_function	enzyme binding
H	0042178	biological_process	xenobiotic catabolic process
H	0042759	biological_process	long-chain fatty acid biosynthetic process
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0043295	molecular_function	glutathione binding
H	0045171	cellular_component	intercellular bridge

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	32
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P08515

Chain	Residue	Details
A	TRP7
C	LEU46
C	LEU59
C	SER72
D	TRP7
D	LEU46
D	LEU59
D	SER72
E	TRP7
E	LEU46
E	LEU59
A	LEU46
E	SER72
F	TRP7
F	LEU46
F	LEU59
F	SER72
G	TRP7
G	LEU46
G	LEU59
G	SER72
H	TRP7
A	LEU59
H	LEU46
H	LEU59
H	SER72
A	SER72
B	TRP7
B	LEU46
B	LEU59
B	SER72
C	TRP7

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	SER116
B	SER116
C	SER116
D	SER116
E	SER116
F	SER116
G	SER116
H	SER116

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
A	TYR6

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
B	TYR6

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
C	TYR6

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
D	TYR6

site_id	CSA5
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
E	TYR6

site_id	CSA6
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
F	TYR6

site_id	CSA7
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
G	TYR6

site_id	CSA8
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
H	TYR6

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)