4GST

REACTION COORDINATE MOTION IN AN SNAR REACTION CATALYZED BY GLUTATHIONE TRANSFERASE

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Functional Information from GO Data

ChainGOidnamespacecontents
A0005829cellular_componentcytosol
A0005576cellular_componentextracellular region
A0032991cellular_componentprotein-containing complex
A0043295molecular_functionglutathione binding
A0004364molecular_functionglutathione transferase activity
A0016151molecular_functionnickel cation binding
A0042803molecular_functionprotein homodimerization activity
A0019901molecular_functionprotein kinase binding
A0005496molecular_functionsteroid binding
A0006749biological_processglutathione metabolic process
A0043200biological_processresponse to amino acid
A0046677biological_processresponse to antibiotic
A0048678biological_processresponse to axon injury
A0042493biological_processresponse to drug
A0045471biological_processresponse to ethanol
A0010288biological_processresponse to lead ion
A0010226biological_processresponse to lithium ion
A0010038biological_processresponse to metal ion
A0007608biological_processsensory perception of smell
A0042178biological_processxenobiotic catabolic process
B0005829cellular_componentcytosol
B0005576cellular_componentextracellular region
B0032991cellular_componentprotein-containing complex
B0043295molecular_functionglutathione binding
B0004364molecular_functionglutathione transferase activity
B0016151molecular_functionnickel cation binding
B0042803molecular_functionprotein homodimerization activity
B0019901molecular_functionprotein kinase binding
B0005496molecular_functionsteroid binding
B0006749biological_processglutathione metabolic process
B0043200biological_processresponse to amino acid
B0046677biological_processresponse to antibiotic
B0048678biological_processresponse to axon injury
B0042493biological_processresponse to drug
B0045471biological_processresponse to ethanol
B0010288biological_processresponse to lead ion
B0010226biological_processresponse to lithium ion
B0010038biological_processresponse to metal ion
B0007608biological_processsensory perception of smell
B0042178biological_processxenobiotic catabolic process
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC19BINDING SITE FOR RESIDUE SO4 A 218
ChainResidue
AARG81
ACYS86
AHOH249
AHOH292
AHOH376
AHOH384
AHOH393
AHOH418
BARG93

AC21BINDING SITE FOR RESIDUE SO4 A 219
ChainResidue
AARG67

AC33BINDING SITE FOR RESIDUE SO4 A 220
ChainResidue
ALYS49
APHE50
AHOH416

AC43BINDING SITE FOR RESIDUE SO4 A 221
ChainResidue
ASER199
AARG201
AHOH398

AC55BINDING SITE FOR RESIDUE SO4 B 218
ChainResidue
BSER199
BARG201
BHOH244
BHOH260
BHOH347

AC64BINDING SITE FOR RESIDUE SO4 B 219
ChainResidue
ALYS121
AHOH321
BARG186
BHOH279

AC725BINDING SITE FOR RESIDUE GTD A 222
ChainResidue
ATYR6
ATRP7
AGLY11
ALEU12
AARG42
ATRP45
ALYS49
AASN58
ALEU59
APRO60
AGLN71
ASER72
AARG107
AILE111
ATYR115
APHE208
ASER209
AHOH224
AHOH226
AHOH243
AHOH273
AHOH314
AHOH375
AHOH378
BASP105

AC822BINDING SITE FOR RESIDUE GTD B 220
ChainResidue
AASP105
AHOH232
BTYR6
BTRP7
BGLY11
BTRP45
BLYS49
BASN58
BLEU59
BPRO60
BGLN71
BSER72
BARG107
BILE111
BTYR115
BPHE208
BHOH221
BHOH225
BHOH263
BHOH280
BHOH330
BHOH348

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
GTD_4gst_A_222271-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE binding site
ChainResidueligand
ATYR6-TRP7GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
AVAL9GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
AGLY11-LEU12GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
AARG42GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
ATRP45-LEU46GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
ALYS49GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
APRO57-PRO60GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
AGLN71-ASN73GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
AMET104GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
AARG107-MET108GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
AILE111GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
ATYR115GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
AGLN165GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
AILE207-SER209GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BASN101GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BASP105GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE

GTD_4gst_B_220271-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE binding site
ChainResidueligand
AASN101GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
AASP105GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BTYR6-TRP7GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BVAL9GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BGLY11-LEU12GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BARG42GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BTRP45-LEU46GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BLYS49GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BPRO57-PRO60GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BGLN71-ASN73GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BMET104GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BARG107-MET108GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BILE111GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BTYR115GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BGLN165GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE
BILE207-SER209GTD: 1-(S-GLUTATHIONYL)-2,4,6-TRINITROCYCLOHEXA-2,5-DIENE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI11Substrate. {ECO:0000250}.
ChainResidueDetails
ATYR115

SWS_FT_FI21Glutathione. {ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735}.
ChainResidueDetails
ALYS49

SWS_FT_FI31Substrate. {ECO:0000250}.
ChainResidueDetails
BTYR115

SWS_FT_FI41Glutathione. {ECO:0000269|PubMed:8664265, ECO:0000305|PubMed:8110735}.
ChainResidueDetails
BLYS49

CSA11Annotated By Reference To The Literature 1oe8
ChainResidueDetails
ATYR6

CSA21Annotated By Reference To The Literature 1oe8
ChainResidueDetails
BTYR6

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Catalytic Information from CSA

site_idNumber of ResiduesDetails
CSA11Annotated By Reference To The Literature 1oe8
ChainResidueDetails
ATYR6

CSA21Annotated By Reference To The Literature 1oe8
ChainResidueDetails
BTYR6