4GSR

Structural basis for the inhibition of Mycobacterium tuberculosis L,D-transpeptidase by meropenem, a drug effective against extensively drug-resistant strains

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016740	molecular_function	transferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EMT A 501

Chain	Residue
A	HIS214
A	PHE215
A	GLU252
A	ILE254
A	HOH654
A	HOH799

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 502

Chain	Residue
A	ASP160
A	ASN204
A	ASN205

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site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 503

Chain	Residue
A	LEU203
A	ASN204
A	TYR330
A	ILE388
A	ASP389
A	HOH700

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000305|PubMed:23103390

Chain	Residue	Details
A	HIS336

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU01373, ECO:0000269|PubMed:23103390

Chain	Residue	Details
A	CYS354

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site_id	SWS_FT_FI3
Number of Residues	3
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASP232
A	GLU235
A	GLY236

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site_id	SWS_FT_FI4
Number of Residues	3
Details	BINDING:

Chain	Residue	Details
A	TYR318
A	SER331
A	ASN356

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site_id	SWS_FT_FI5
Number of Residues	1
Details	SITE: Binds to carbapenem drug (covalent) => ECO:0000250

Chain	Residue	Details
A	CYS354

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