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4GSL

Crystal structure of an Atg7-Atg3 crosslinked complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000407cellular_componentphagophore assembly site
A0000422biological_processautophagy of mitochondrion
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005829cellular_componentcytosol
A0006914biological_processautophagy
A0006995biological_processcellular response to nitrogen starvation
A0008270molecular_functionzinc ion binding
A0008641molecular_functionubiquitin-like modifier activating enzyme activity
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016236biological_processmacroautophagy
A0019778molecular_functionAtg12 activating enzyme activity
A0019779molecular_functionAtg8 activating enzyme activity
A0032258biological_processcytoplasm to vacuole targeting by the Cvt pathway
A0032446biological_processprotein modification by small protein conjugation
A0034727biological_processpiecemeal microautophagy of the nucleus
A0042802molecular_functionidentical protein binding
A0044804biological_processnucleophagy
A0097632cellular_componentextrinsic component of phagophore assembly site membrane
B0000407cellular_componentphagophore assembly site
B0000422biological_processautophagy of mitochondrion
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005829cellular_componentcytosol
B0006914biological_processautophagy
B0006995biological_processcellular response to nitrogen starvation
B0008270molecular_functionzinc ion binding
B0008641molecular_functionubiquitin-like modifier activating enzyme activity
B0015031biological_processprotein transport
B0016020cellular_componentmembrane
B0016236biological_processmacroautophagy
B0019778molecular_functionAtg12 activating enzyme activity
B0019779molecular_functionAtg8 activating enzyme activity
B0032258biological_processcytoplasm to vacuole targeting by the Cvt pathway
B0032446biological_processprotein modification by small protein conjugation
B0034727biological_processpiecemeal microautophagy of the nucleus
B0042802molecular_functionidentical protein binding
B0044804biological_processnucleophagy
B0097632cellular_componentextrinsic component of phagophore assembly site membrane
C0000045biological_processautophagosome assembly
C0000407cellular_componentphagophore assembly site
C0000422biological_processautophagy of mitochondrion
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005829cellular_componentcytosol
C0006612biological_processprotein targeting to membrane
C0006914biological_processautophagy
C0015031biological_processprotein transport
C0019776molecular_functionAtg8-family ligase activity
C0019787molecular_functionubiquitin-like protein transferase activity
C0032258biological_processcytoplasm to vacuole targeting by the Cvt pathway
C0034727biological_processpiecemeal microautophagy of the nucleus
C0044804biological_processnucleophagy
C0061723biological_processglycophagy
C0061908cellular_componentphagophore
C0141046molecular_functionAtg8-family conjugating enzyme activity
D0000045biological_processautophagosome assembly
D0000407cellular_componentphagophore assembly site
D0000422biological_processautophagy of mitochondrion
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005829cellular_componentcytosol
D0006612biological_processprotein targeting to membrane
D0006914biological_processautophagy
D0015031biological_processprotein transport
D0019776molecular_functionAtg8-family ligase activity
D0019787molecular_functionubiquitin-like protein transferase activity
D0032258biological_processcytoplasm to vacuole targeting by the Cvt pathway
D0034727biological_processpiecemeal microautophagy of the nucleus
D0044804biological_processnucleophagy
D0061723biological_processglycophagy
D0061908cellular_componentphagophore
D0141046molecular_functionAtg8-family conjugating enzyme activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 700
ChainResidue
ACYS485
ACYS488
ACYS569
ACYS572

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 700
ChainResidue
BCYS485
BCYS488
BCYS569
BCYS572

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Glycyl thioester intermediate => ECO:0000255
ChainResidueDetails
CCYS234
DCYS234

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING:
ChainResidueDetails
CMET1
DMET1

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; by ESA1 => ECO:0000269|PubMed:22539722
ChainResidueDetails
CLYS19
CLYS48
DLYS19
DLYS48

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PDB entries from 2024-07-24

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