4GGC

Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0010997	molecular_function	anaphase-promoting complex binding
A	0097027	molecular_function	ubiquitin-protein transferase activator activity
A	1904668	biological_process	positive regulation of ubiquitin protein ligase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MRD A 501

Chain	Residue
A	ASP177
A	ILE216
A	HOH921

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MRD A 502

Chain	Residue
A	HOH1007
A	LEU208
A	SER210
A	ASP215
A	VAL255
A	GLN353
A	HOH930

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MRD A 503

Chain	Residue
A	HIS292
A	SER338
A	ALA339

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MRD A 504

Chain	Residue
A	ARG286
A	SER309
A	PRO453
A	ASP454
A	HOH802
A	HOH917

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Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. TGGGtsDrHIRIWNV

Chain	Residue	Details
A	THR373-VAL387

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Repeat: {"description":"WD 1","evidences":[{"source":"PubMed","id":"27120157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27509861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	41
Details	Repeat: {"description":"WD 2","evidences":[{"source":"PubMed","id":"27120157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27509861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	35
Details	Repeat: {"description":"WD 3","evidences":[{"source":"PubMed","id":"27120157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27509861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	42
Details	Repeat: {"description":"WD 4","evidences":[{"source":"PubMed","id":"27120157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27509861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	42
Details	Repeat: {"description":"WD 5","evidences":[{"source":"PubMed","id":"27120157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27509861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	40
Details	Repeat: {"description":"WD 6","evidences":[{"source":"PubMed","id":"27120157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27509861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	29
Details	Repeat: {"description":"WD 7","evidences":[{"source":"PubMed","id":"27120157","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27509861","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5G04","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5LCW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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