4GAW
Crystal structure of active human granzyme H
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0006915 | biological_process | apoptotic process |
| A | 0016020 | cellular_component | membrane |
| A | 0044194 | cellular_component | cytolytic granule |
| A | 0051604 | biological_process | protein maturation |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0006915 | biological_process | apoptotic process |
| B | 0016020 | cellular_component | membrane |
| B | 0044194 | cellular_component | cytolytic granule |
| B | 0051604 | biological_process | protein maturation |
| C | 0004252 | molecular_function | serine-type endopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0006915 | biological_process | apoptotic process |
| C | 0016020 | cellular_component | membrane |
| C | 0044194 | cellular_component | cytolytic granule |
| C | 0051604 | biological_process | protein maturation |
| D | 0004252 | molecular_function | serine-type endopeptidase activity |
| D | 0006508 | biological_process | proteolysis |
| D | 0006915 | biological_process | apoptotic process |
| D | 0016020 | cellular_component | membrane |
| D | 0044194 | cellular_component | cytolytic granule |
| D | 0051604 | biological_process | protein maturation |
| E | 0004252 | molecular_function | serine-type endopeptidase activity |
| E | 0006508 | biological_process | proteolysis |
| E | 0006915 | biological_process | apoptotic process |
| E | 0016020 | cellular_component | membrane |
| E | 0044194 | cellular_component | cytolytic granule |
| E | 0051604 | biological_process | protein maturation |
| F | 0004252 | molecular_function | serine-type endopeptidase activity |
| F | 0006508 | biological_process | proteolysis |
| F | 0006915 | biological_process | apoptotic process |
| F | 0016020 | cellular_component | membrane |
| F | 0044194 | cellular_component | cytolytic granule |
| F | 0051604 | biological_process | protein maturation |
| G | 0004252 | molecular_function | serine-type endopeptidase activity |
| G | 0006508 | biological_process | proteolysis |
| G | 0006915 | biological_process | apoptotic process |
| G | 0016020 | cellular_component | membrane |
| G | 0044194 | cellular_component | cytolytic granule |
| G | 0051604 | biological_process | protein maturation |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0006508 | biological_process | proteolysis |
| H | 0006915 | biological_process | apoptotic process |
| H | 0016020 | cellular_component | membrane |
| H | 0044194 | cellular_component | cytolytic granule |
| H | 0051604 | biological_process | protein maturation |
| I | 0004252 | molecular_function | serine-type endopeptidase activity |
| I | 0006508 | biological_process | proteolysis |
| I | 0006915 | biological_process | apoptotic process |
| I | 0016020 | cellular_component | membrane |
| I | 0044194 | cellular_component | cytolytic granule |
| I | 0051604 | biological_process | protein maturation |
| J | 0004252 | molecular_function | serine-type endopeptidase activity |
| J | 0006508 | biological_process | proteolysis |
| J | 0006915 | biological_process | apoptotic process |
| J | 0016020 | cellular_component | membrane |
| J | 0044194 | cellular_component | cytolytic granule |
| J | 0051604 | biological_process | protein maturation |
| K | 0004252 | molecular_function | serine-type endopeptidase activity |
| K | 0006508 | biological_process | proteolysis |
| K | 0006915 | biological_process | apoptotic process |
| K | 0016020 | cellular_component | membrane |
| K | 0044194 | cellular_component | cytolytic granule |
| K | 0051604 | biological_process | protein maturation |
| L | 0004252 | molecular_function | serine-type endopeptidase activity |
| L | 0006508 | biological_process | proteolysis |
| L | 0006915 | biological_process | apoptotic process |
| L | 0016020 | cellular_component | membrane |
| L | 0044194 | cellular_component | cytolytic granule |
| L | 0051604 | biological_process | protein maturation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 301 |
| Chain | Residue |
| B | CYS203 |
| B | LYS204 |
| B | ASP205 |
| G | ARG41 |
| G | LYS75 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 302 |
| Chain | Residue |
| B | LYS194 |
| B | GLY195 |
| B | SER197 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 B 303 |
| Chain | Residue |
| A | LYS204 |
| B | ARG41 |
| A | LEU136 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 304 |
| Chain | Residue |
| B | ASN96 |
| B | ASN99 |
| B | SER101 |
| D | SER101 |
| D | ASN102 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL C 301 |
| Chain | Residue |
| C | LYS42 |
| C | SER197 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 D 301 |
| Chain | Residue |
| B | ARG50 |
| D | ARG50 |
| D | LYS51 |
| D | LYS112 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 D 302 |
| Chain | Residue |
| D | LYS204 |
| D | ASP205 |
| H | ARG41 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 D 303 |
| Chain | Residue |
| B | ARG50 |
| B | LYS51 |
| B | ARG123 |
| D | ARG50 |
| D | LYS239 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE CL D 304 |
| Chain | Residue |
| D | GLY195 |
| D | SER197 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 E 301 |
| Chain | Residue |
| E | ARG41 |
| E | LYS75 |
| H | LEU136 |
| H | LYS204 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 301 |
| Chain | Residue |
| F | CYS203 |
| F | LYS204 |
| I | ARG41 |
| I | LYS75 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 F 302 |
| Chain | Residue |
| F | ARG41 |
| G | LEU136 |
| G | LYS204 |
| G | ASP205 |
| site_id | BC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 F 303 |
| Chain | Residue |
| I | GLU78 |
| I | ARG79 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 I 301 |
| Chain | Residue |
| C | ASN96 |
| C | SER101 |
| C | ASN102 |
| I | SER101 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 I 302 |
| Chain | Residue |
| I | CYS203 |
| I | LYS204 |
| I | ASP205 |
| J | ARG41 |
| J | LYS75 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 L 301 |
| Chain | Residue |
| L | PHE32 |
| L | GLN34 |
| L | ARG41 |
| L | LYS42 |
| L | ARG43 |
| site_id | BC8 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 L 302 |
| Chain | Residue |
| D | ARG41 |
| L | LEU136 |
| L | LYS204 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | Region: {"description":"Mediates the preference for acidic residues at the P3' and P4' sites"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"UniProtKB","id":"P49863","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 36 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2230 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
