Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GAW

Crystal structure of active human granzyme H

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0031640	biological_process	killing of cells of another organism
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0044194	cellular_component	cytolytic granule
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0006508	biological_process	proteolysis
B	0006915	biological_process	apoptotic process
B	0008236	molecular_function	serine-type peptidase activity
B	0016020	cellular_component	membrane
B	0031640	biological_process	killing of cells of another organism
B	0043231	cellular_component	intracellular membrane-bounded organelle
B	0044194	cellular_component	cytolytic granule
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0006508	biological_process	proteolysis
C	0006915	biological_process	apoptotic process
C	0008236	molecular_function	serine-type peptidase activity
C	0016020	cellular_component	membrane
C	0031640	biological_process	killing of cells of another organism
C	0043231	cellular_component	intracellular membrane-bounded organelle
C	0044194	cellular_component	cytolytic granule
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0006508	biological_process	proteolysis
D	0006915	biological_process	apoptotic process
D	0008236	molecular_function	serine-type peptidase activity
D	0016020	cellular_component	membrane
D	0031640	biological_process	killing of cells of another organism
D	0043231	cellular_component	intracellular membrane-bounded organelle
D	0044194	cellular_component	cytolytic granule
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0006508	biological_process	proteolysis
E	0006915	biological_process	apoptotic process
E	0008236	molecular_function	serine-type peptidase activity
E	0016020	cellular_component	membrane
E	0031640	biological_process	killing of cells of another organism
E	0043231	cellular_component	intracellular membrane-bounded organelle
E	0044194	cellular_component	cytolytic granule
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0006508	biological_process	proteolysis
F	0006915	biological_process	apoptotic process
F	0008236	molecular_function	serine-type peptidase activity
F	0016020	cellular_component	membrane
F	0031640	biological_process	killing of cells of another organism
F	0043231	cellular_component	intracellular membrane-bounded organelle
F	0044194	cellular_component	cytolytic granule
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005737	cellular_component	cytoplasm
G	0005764	cellular_component	lysosome
G	0006508	biological_process	proteolysis
G	0006915	biological_process	apoptotic process
G	0008236	molecular_function	serine-type peptidase activity
G	0016020	cellular_component	membrane
G	0031640	biological_process	killing of cells of another organism
G	0043231	cellular_component	intracellular membrane-bounded organelle
G	0044194	cellular_component	cytolytic granule
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005737	cellular_component	cytoplasm
H	0005764	cellular_component	lysosome
H	0006508	biological_process	proteolysis
H	0006915	biological_process	apoptotic process
H	0008236	molecular_function	serine-type peptidase activity
H	0016020	cellular_component	membrane
H	0031640	biological_process	killing of cells of another organism
H	0043231	cellular_component	intracellular membrane-bounded organelle
H	0044194	cellular_component	cytolytic granule
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005737	cellular_component	cytoplasm
I	0005764	cellular_component	lysosome
I	0006508	biological_process	proteolysis
I	0006915	biological_process	apoptotic process
I	0008236	molecular_function	serine-type peptidase activity
I	0016020	cellular_component	membrane
I	0031640	biological_process	killing of cells of another organism
I	0043231	cellular_component	intracellular membrane-bounded organelle
I	0044194	cellular_component	cytolytic granule
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005737	cellular_component	cytoplasm
J	0005764	cellular_component	lysosome
J	0006508	biological_process	proteolysis
J	0006915	biological_process	apoptotic process
J	0008236	molecular_function	serine-type peptidase activity
J	0016020	cellular_component	membrane
J	0031640	biological_process	killing of cells of another organism
J	0043231	cellular_component	intracellular membrane-bounded organelle
J	0044194	cellular_component	cytolytic granule
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005737	cellular_component	cytoplasm
K	0005764	cellular_component	lysosome
K	0006508	biological_process	proteolysis
K	0006915	biological_process	apoptotic process
K	0008236	molecular_function	serine-type peptidase activity
K	0016020	cellular_component	membrane
K	0031640	biological_process	killing of cells of another organism
K	0043231	cellular_component	intracellular membrane-bounded organelle
K	0044194	cellular_component	cytolytic granule
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005737	cellular_component	cytoplasm
L	0005764	cellular_component	lysosome
L	0006508	biological_process	proteolysis
L	0006915	biological_process	apoptotic process
L	0008236	molecular_function	serine-type peptidase activity
L	0016020	cellular_component	membrane
L	0031640	biological_process	killing of cells of another organism
L	0043231	cellular_component	intracellular membrane-bounded organelle
L	0044194	cellular_component	cytolytic granule

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 301

Chain	Residue
B	CYS203
B	LYS204
B	ASP205
G	ARG41
G	LYS75

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	LYS194
B	GLY195
B	SER197

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
A	LYS204
B	ARG41
A	LEU136

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 304

Chain	Residue
B	ASN96
B	ASN99
B	SER101
D	SER101
D	ASN102

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 301

Chain	Residue
C	LYS42
C	SER197

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 301

Chain	Residue
B	ARG50
D	ARG50
D	LYS51
D	LYS112

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 302

Chain	Residue
D	LYS204
D	ASP205
H	ARG41

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 303

Chain	Residue
B	ARG50
B	LYS51
B	ARG123
D	ARG50
D	LYS239

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 304

Chain	Residue
D	GLY195
D	SER197

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 301

Chain	Residue
E	ARG41
E	LYS75
H	LEU136
H	LYS204

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 301

Chain	Residue
F	CYS203
F	LYS204
I	ARG41
I	LYS75

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 302

Chain	Residue
F	ARG41
G	LEU136
G	LYS204
G	ASP205

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 303

Chain	Residue
I	GLU78
I	ARG79

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 I 301

Chain	Residue
C	ASN96
C	SER101
C	ASN102
I	SER101

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 I 302

Chain	Residue
I	CYS203
I	LYS204
I	ASP205
J	ARG41
J	LYS75

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 301

Chain	Residue
L	PHE32
L	GLN34
L	ARG41
L	LYS42
L	ARG43

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 302

Chain	Residue
D	ARG41
L	LEU136
L	LYS204

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU55-CYS60

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. TGfkGDSGGPLV

Chain	Residue	Details
A	THR191-VAL202

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	ACT_SITE: Charge relay system => ECO:0000250

Chain	Residue	Details
A	HIS59
D	HIS59
D	ASP103
D	SER197
E	HIS59
E	ASP103
E	SER197
F	HIS59
F	ASP103
F	SER197
G	HIS59
A	ASP103
G	ASP103
G	SER197
H	HIS59
H	ASP103
H	SER197
I	HIS59
I	ASP103
I	SER197
J	HIS59
J	ASP103
A	SER197
J	SER197
K	HIS59
K	ASP103
K	SER197
L	HIS59
L	ASP103
L	SER197
B	HIS59
B	ASP103
B	SER197
C	HIS59
C	ASP103
C	SER197

site_id	SWS_FT_FI2
Number of Residues	36
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN66
D	ASN66
D	ASN99
D	ASN174
E	ASN66
E	ASN99
E	ASN174
F	ASN66
F	ASN99
F	ASN174
G	ASN66
A	ASN99
G	ASN99
G	ASN174
H	ASN66
H	ASN99
H	ASN174
I	ASN66
I	ASN99
I	ASN174
J	ASN66
J	ASN99
A	ASN174
J	ASN174
K	ASN66
K	ASN99
K	ASN174
L	ASN66
L	ASN99
L	ASN174
B	ASN66
B	ASN99
B	ASN174
C	ASN66
C	ASN99
C	ASN174

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)