Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4GAW

Crystal structure of active human granzyme H

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0006915	biological_process	apoptotic process
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0031640	biological_process	killing of cells of another organism
A	0044194	cellular_component	cytolytic granule
A	0051604	biological_process	protein maturation
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005615	cellular_component	extracellular space
B	0006508	biological_process	proteolysis
B	0006915	biological_process	apoptotic process
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0031640	biological_process	killing of cells of another organism
B	0044194	cellular_component	cytolytic granule
B	0051604	biological_process	protein maturation
C	0004252	molecular_function	serine-type endopeptidase activity
C	0005615	cellular_component	extracellular space
C	0006508	biological_process	proteolysis
C	0006915	biological_process	apoptotic process
C	0008233	molecular_function	peptidase activity
C	0008236	molecular_function	serine-type peptidase activity
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0031640	biological_process	killing of cells of another organism
C	0044194	cellular_component	cytolytic granule
C	0051604	biological_process	protein maturation
D	0004252	molecular_function	serine-type endopeptidase activity
D	0005615	cellular_component	extracellular space
D	0006508	biological_process	proteolysis
D	0006915	biological_process	apoptotic process
D	0008233	molecular_function	peptidase activity
D	0008236	molecular_function	serine-type peptidase activity
D	0016020	cellular_component	membrane
D	0016787	molecular_function	hydrolase activity
D	0031640	biological_process	killing of cells of another organism
D	0044194	cellular_component	cytolytic granule
D	0051604	biological_process	protein maturation
E	0004252	molecular_function	serine-type endopeptidase activity
E	0005615	cellular_component	extracellular space
E	0006508	biological_process	proteolysis
E	0006915	biological_process	apoptotic process
E	0008233	molecular_function	peptidase activity
E	0008236	molecular_function	serine-type peptidase activity
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0031640	biological_process	killing of cells of another organism
E	0044194	cellular_component	cytolytic granule
E	0051604	biological_process	protein maturation
F	0004252	molecular_function	serine-type endopeptidase activity
F	0005615	cellular_component	extracellular space
F	0006508	biological_process	proteolysis
F	0006915	biological_process	apoptotic process
F	0008233	molecular_function	peptidase activity
F	0008236	molecular_function	serine-type peptidase activity
F	0016020	cellular_component	membrane
F	0016787	molecular_function	hydrolase activity
F	0031640	biological_process	killing of cells of another organism
F	0044194	cellular_component	cytolytic granule
F	0051604	biological_process	protein maturation
G	0004252	molecular_function	serine-type endopeptidase activity
G	0005615	cellular_component	extracellular space
G	0006508	biological_process	proteolysis
G	0006915	biological_process	apoptotic process
G	0008233	molecular_function	peptidase activity
G	0008236	molecular_function	serine-type peptidase activity
G	0016020	cellular_component	membrane
G	0016787	molecular_function	hydrolase activity
G	0031640	biological_process	killing of cells of another organism
G	0044194	cellular_component	cytolytic granule
G	0051604	biological_process	protein maturation
H	0004252	molecular_function	serine-type endopeptidase activity
H	0005615	cellular_component	extracellular space
H	0006508	biological_process	proteolysis
H	0006915	biological_process	apoptotic process
H	0008233	molecular_function	peptidase activity
H	0008236	molecular_function	serine-type peptidase activity
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0031640	biological_process	killing of cells of another organism
H	0044194	cellular_component	cytolytic granule
H	0051604	biological_process	protein maturation
I	0004252	molecular_function	serine-type endopeptidase activity
I	0005615	cellular_component	extracellular space
I	0006508	biological_process	proteolysis
I	0006915	biological_process	apoptotic process
I	0008233	molecular_function	peptidase activity
I	0008236	molecular_function	serine-type peptidase activity
I	0016020	cellular_component	membrane
I	0016787	molecular_function	hydrolase activity
I	0031640	biological_process	killing of cells of another organism
I	0044194	cellular_component	cytolytic granule
I	0051604	biological_process	protein maturation
J	0004252	molecular_function	serine-type endopeptidase activity
J	0005615	cellular_component	extracellular space
J	0006508	biological_process	proteolysis
J	0006915	biological_process	apoptotic process
J	0008233	molecular_function	peptidase activity
J	0008236	molecular_function	serine-type peptidase activity
J	0016020	cellular_component	membrane
J	0016787	molecular_function	hydrolase activity
J	0031640	biological_process	killing of cells of another organism
J	0044194	cellular_component	cytolytic granule
J	0051604	biological_process	protein maturation
K	0004252	molecular_function	serine-type endopeptidase activity
K	0005615	cellular_component	extracellular space
K	0006508	biological_process	proteolysis
K	0006915	biological_process	apoptotic process
K	0008233	molecular_function	peptidase activity
K	0008236	molecular_function	serine-type peptidase activity
K	0016020	cellular_component	membrane
K	0016787	molecular_function	hydrolase activity
K	0031640	biological_process	killing of cells of another organism
K	0044194	cellular_component	cytolytic granule
K	0051604	biological_process	protein maturation
L	0004252	molecular_function	serine-type endopeptidase activity
L	0005615	cellular_component	extracellular space
L	0006508	biological_process	proteolysis
L	0006915	biological_process	apoptotic process
L	0008233	molecular_function	peptidase activity
L	0008236	molecular_function	serine-type peptidase activity
L	0016020	cellular_component	membrane
L	0016787	molecular_function	hydrolase activity
L	0031640	biological_process	killing of cells of another organism
L	0044194	cellular_component	cytolytic granule
L	0051604	biological_process	protein maturation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 301

Chain	Residue
B	CYS203
B	LYS204
B	ASP205
G	ARG41
G	LYS75

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 302

Chain	Residue
B	LYS194
B	GLY195
B	SER197

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 303

Chain	Residue
A	LYS204
B	ARG41
A	LEU136

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 304

Chain	Residue
B	ASN96
B	ASN99
B	SER101
D	SER101
D	ASN102

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL C 301

Chain	Residue
C	LYS42
C	SER197

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 301

Chain	Residue
B	ARG50
D	ARG50
D	LYS51
D	LYS112

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 302

Chain	Residue
D	LYS204
D	ASP205
H	ARG41

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 303

Chain	Residue
B	ARG50
B	LYS51
B	ARG123
D	ARG50
D	LYS239

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL D 304

Chain	Residue
D	GLY195
D	SER197

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 E 301

Chain	Residue
E	ARG41
E	LYS75
H	LEU136
H	LYS204

site_id	BC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 301

Chain	Residue
F	CYS203
F	LYS204
I	ARG41
I	LYS75

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 302

Chain	Residue
F	ARG41
G	LEU136
G	LYS204
G	ASP205

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 F 303

Chain	Residue
I	GLU78
I	ARG79

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 I 301

Chain	Residue
C	ASN96
C	SER101
C	ASN102
I	SER101

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 I 302

Chain	Residue
I	CYS203
I	LYS204
I	ASP205
J	ARG41
J	LYS75

site_id	BC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 L 301

Chain	Residue
L	PHE32
L	GLN34
L	ARG41
L	LYS42
L	ARG43

site_id	BC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 L 302

Chain	Residue
D	ARG41
L	LEU136
L	LYS204

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU55-CYS60

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. TGfkGDSGGPLV

Chain	Residue	Details
A	THR191-VAL202

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	24
Details	Region: {"description":"Mediates the preference for acidic residues at the P3' and P4' sites"}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	36
Details	Active site: {"description":"Charge relay system","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	36
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	2230
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)