4GA7

Crystal structure of human serpinB1 mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004867	molecular_function	serine-type endopeptidase inhibitor activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005769	cellular_component	early endosome
A	0005829	cellular_component	cytosol
A	0010951	biological_process	negative regulation of endopeptidase activity
A	0016020	cellular_component	membrane
A	0030336	biological_process	negative regulation of cell migration
A	0030414	molecular_function	peptidase inhibitor activity
A	0031012	cellular_component	extracellular matrix
A	0032691	biological_process	negative regulation of interleukin-1 beta production
A	0034774	cellular_component	secretory granule lumen
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0044194	cellular_component	cytolytic granule
A	0044342	biological_process	type B pancreatic cell proliferation
A	0051246	biological_process	regulation of protein metabolic process
A	0070062	cellular_component	extracellular exosome
B	0004867	molecular_function	serine-type endopeptidase inhibitor activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005769	cellular_component	early endosome
B	0005829	cellular_component	cytosol
B	0010951	biological_process	negative regulation of endopeptidase activity
B	0016020	cellular_component	membrane
B	0030336	biological_process	negative regulation of cell migration
B	0030414	molecular_function	peptidase inhibitor activity
B	0031012	cellular_component	extracellular matrix
B	0032691	biological_process	negative regulation of interleukin-1 beta production
B	0034774	cellular_component	secretory granule lumen
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0044194	cellular_component	cytolytic granule
B	0044342	biological_process	type B pancreatic cell proliferation
B	0051246	biological_process	regulation of protein metabolic process
B	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00284
Number of Residues	11
Details	SERPIN Serpins signature. FTADHPFLFfI

Chain	Residue	Details
A	PHE352-ILE362

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	56
Details	Region: {"description":"CARD-binding motif (CBM)","evidences":[{"source":"PubMed","id":"30692621","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Reactive bond 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Site: {"description":"Reactive bond 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"12665801","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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